scholarly journals Human Endogenous Retrovirus (HERV-K) Reverse Transcriptase as a Breast Cancer Prognostic Marker

Neoplasia ◽  
2008 ◽  
Vol 10 (6) ◽  
pp. 521-IN2 ◽  
Author(s):  
Maya Golan ◽  
Amnon Hizi ◽  
James H. Resau ◽  
Neora Yaal-Hahoshen ◽  
Hadar Reichman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Reverse Transcriptase ◽  
Prognostic Marker ◽  
Endogenous Retrovirus ◽  
Human Endogenous Retrovirus

scholarly journals Human Endogenous Retrovirus K (HML-2) Elements in the Plasma of People with Lymphoma and Breast Cancer

2008 ◽  
Vol 82 (19) ◽  
pp. 9329-9336 ◽  
Author(s):  
Rafael Contreras-Galindo ◽  
Mark H. Kaplan ◽  
Philippe Leissner ◽  
Thibault Verjat ◽  
Ilaria Ferlenghi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Reverse Transcriptase ◽  
Human Genome ◽  
Genetic Material ◽  
Human Tumor ◽  
Endogenous Retrovirus ◽  
Endogenous Retroviruses ◽  
Human Endogenous Retrovirus ◽  
Plasma Fractions ◽  
Stable Part

ABSTRACT Actively replicating endogenous retroviruses entered the human genome millions of years ago and became a stable part of the inherited genetic material. They subsequently acquired multiple mutations, leading to the assumption that these viruses no longer replicate. However, certain human tumor cell lines have been shown to release endogenous retroviral particles. Here we show that RNA from human endogenous retrovirus K (HERV-K) (HML-2), a relatively recent entrant into the human genome, can be found in very high titers in the plasma of patients with lymphomas and breast cancer as measured by either reverse transcriptase PCR or nucleic acid sequence-based amplification. Further, these titers drop dramatically with cancer treatment. We also demonstrate the presence of reverse transcriptase and viral RNA in plasma fractions that contain both immature and correctly processed HERV-K (HML-2) Gag and envelope proteins. Finally, using immunoelectron microscopy, we show the presence of HERV-K (HML-2) virus-like particles in the plasma of lymphoma patients. Taken together, these findings demonstrate that elements of the endogenous retrovirus HERV-K (HML-2) can be found in the blood of modern-day humans with certain cancers.

scholarly journals Expression of human endogenous retrovirus-K is strongly associated with the basal-like breast cancer phenotype

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Gary L. Johanning ◽  
Gabriel G. Malouf ◽  
Xiaofeng Zheng ◽  
Francisco J. Esteva ◽  
John N. Weinstein ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Endogenous Retrovirus ◽  
Human Endogenous Retrovirus ◽  
Basal Like Breast Cancer ◽  
Cancer Phenotype

scholarly journals Expression of Human Endogenous Retrovirus env Genes in the Blood of Breast Cancer Patients

2014 ◽  
Vol 15 (6) ◽  
pp. 9173-9183 ◽  
Author(s):  
Dong-Won Rhyu ◽  
Yun-Jeong Kang ◽  
Mee-Sun Ock ◽  
Jung-Woo Eo ◽  
Yung-Hyun Choi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Endogenous Retrovirus ◽  
Human Endogenous Retrovirus ◽  
Breast Cancer Patients

scholarly journals The role of human endogenous retrovirus LTR70 in breast cancer

The Breast ◽  
2017 ◽  
Vol 32 ◽  
pp. S36
Author(s):  
X. Jin ◽  
X.-E. Xu ◽  
Z.-M. Shao
Keyword(s):  
Breast Cancer ◽  
Endogenous Retrovirus ◽  
Human Endogenous Retrovirus
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