scholarly journals Molecular Analysis of a Multistep Lung Cancer Model Induced by Chronic Inflammation Reveals Epigenetic Regulation of p16, Activation of the DNA Damage Response Pathway

Neoplasia ◽  
2007 ◽  
Vol 9 (10) ◽  
pp. 840-IN12 ◽  
Author(s):  
David Blanco ◽  
Silvestre Vicent ◽  
Mario F. Fraga ◽  
Ignacio Fernandez-Garcia ◽  
Javier Freire ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Damage ◽  
Chronic Inflammation ◽  
Molecular Analysis ◽  
Dna Damage Response ◽  
Epigenetic Regulation ◽  
Cancer Model ◽  
Damage Response ◽  
Lung Cancer Model ◽  
Dna Damage Response Pathway

scholarly journals Efavirenz induces DNA damage response pathway in lung cancer

Oncotarget ◽  
2020 ◽  
Vol 11 (41) ◽  
pp. 3737-3748
Author(s):  
Rahaba Marima ◽  
Rodney Hull ◽  
Zodwa Dlamini ◽  
Clement Penny
Keyword(s):  
Lung Cancer ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Damage Response ◽  
Dna Damage Response Pathway

scholarly journals DNA Damage Response Pathway and Replication Fork Stress During Oligonucleotide Directed Gene Editing

2012 ◽  
Vol 1 ◽  
pp. e18 ◽  
Author(s):  
Melissa Bonner ◽  
Bryan Strouse ◽  
Mindy Applegate ◽  
Paula Livingston ◽  
Eric B Kmiec
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Replication Fork ◽  
Gene Editing ◽  
Damage Response ◽  
Dna Damage Response Pathway

scholarly journals Structural basis of γH2AX recognition by human PTIP BRCT5-BRCT6 domains in the DNA damage response pathway

FEBS Letters ◽  
2011 ◽  
Vol 585 (24) ◽  
pp. 3874-3879 ◽  
Author(s):  
Wei Yan ◽  
Zhenhua Shao ◽  
Fudong Li ◽  
Liwen Niu ◽  
Yunyu Shi ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Structural Basis ◽  
Damage Response ◽  
Dna Damage Response Pathway

scholarly journals RTT109 AND Fun30 proteins mediate epigenetic regulation of the DNA damage response pathway in C. albicans

2021 ◽  
Author(s):  
Prashant Kumar Maurya ◽  
Pramita Garai ◽  
Kaveri Goel ◽  
Himanshu Bhatt ◽  
Aarti Goyal ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Regulation Of Gene Expression ◽  
Repair Pathway ◽  
Fungal Cell ◽  
Opportunistic Fungi ◽  
Damage Response ◽  
H3 Acetylation ◽  
Dna Damage Response Pathway

Fun30, an ATP-dependent chromatin remodeller, from S. cerevisiae mediates both regulation of gene expression as well as DNA damage response/repair. In this paper, we have characterized the biochemical and physiological function of Fun30 from the opportunistic fungi, C. albicans. Biochemically, the protein shows DNA-stimulated ATPase activity. Physiologically, the protein co-regulates transcription of RTT109, TEL1, MEC1, and SNF2-genes that encode for proteins involved in DNA damage response and repair pathway. The expression of FUN30, in turn, is regulated by histone H3 acetylation catalysed by Rtt109 encoded by RTT109. The RTT109Hz/FUN30Hz mutant strain shows sensitivity to oxidative stress and resistance to MMS as compared to the wild type strain. Quantitative PCR showed that the sensitivity to oxidative stress results from downregulation of MEC1, RAD9, MRC1 and RAD5 expression; ChIP experiments showed Fun30 but not H3ac regulates the expression of these genes in response to oxidative stress. In contrast, on treatment with MMS, the expression of RAD9 is upregulated and this upregulation is co-regulated by both Fun30 and H3 acetylation catalysed by Rtt109. Thus, Fun30 and H3 acetylation mediate the response of the fungal cell to genotoxic agents in C. albicans by regulating the expression of DNA damage response and repair pathway genes.

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