scholarly journals AP-2γ Induces p21 Expression, Arrests Cell Cycle, Inhibits the Tumor Growth of Human Carcinoma Cells

Neoplasia ◽  
2006 ◽  
Vol 8 (7) ◽  
pp. 568-577 ◽  
Author(s):  
Hualei Li ◽  
Prabhat C. Goswami ◽  
Frederick E. Domann
Keyword(s):  
Cell Cycle ◽  
Tumor Growth ◽  
Carcinoma Cells ◽  
Human Carcinoma

p53 and vascular endothelial growth factor regulate tumor growth of NOS2-expressing human carcinoma cells

10.1038/3957 ◽  
1998 ◽  
Vol 4 (12) ◽  
pp. 1371-1376 ◽  
Author(s):  
Stefan Ambs ◽  
William G. Merriam ◽  
Mofolusara O. Ogunfusika ◽  
William P. Bennett ◽  
Naoko Ishibe ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Tumor Growth ◽  
Carcinoma Cells ◽  
Vascular Endothelial ◽  
Human Carcinoma ◽  
Endothelial Growth Factor

scholarly journals Bcl-2 activates a programme of premature senescence in human carcinoma cells

2003 ◽  
Vol 375 (2) ◽  
pp. 263-274 ◽  
Author(s):  
Elvira CRESCENZI ◽  
Giuseppe PALUMBO ◽  
Hugh J. M. BRADY
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cell Cycle Progression ◽  
Constitutive Expression ◽  
Carcinoma Cells ◽  
Quiescent State ◽  
Premature Senescence ◽  
Human Carcinoma ◽  
Morphological Alterations ◽  
Cycle Arrest

The apoptosis regulator Bcl-2 has been shown to modulate cell-cycle progression, favouring a quiescent state over a proliferative state, in both normal and tumour cells. We show here that constitutive expression of Bcl-2 in human carcinoma cells results in a cell-cycle arrest that within a few days can become irreversible. Arrested cells acquire a senescent-like phenotype, which consists of several characteristic morphological alterations and increased activity of senescence-associated β-galactosidase. The induction of the premature senescence programme is mediated by inhibition of Cdk2 kinase activity, and p27KIP1 is required to maintain the senescent phenotype. We propose that the ability to activate an endogenous premature senescence programme allows Bcl-2 to suppress tumour growth. These results suggest that the down-regulation of Bcl-2 expression, which has been observed during the development and progression of human carcinoma, is related to the ability of Bcl-2 to severely hamper the growth of carcinoma cells and to induce a permanent cell-cycle arrest, with the features of senescence.

scholarly journals Loss of p21 disrupts p14ARF-induced G1 cell cycle arrest but augments p14ARF-induced apoptosis in human carcinoma cells

Oncogene ◽  
2005 ◽  
Vol 24 (25) ◽  
pp. 4114-4128 ◽  
Author(s):  
Philipp G Hemmati ◽  
Guillaume Normand ◽  
Berlinda Verdoodt ◽  
Clarissa von Haefen ◽  
Anne Hasenjäger ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Carcinoma Cells ◽  
Human Carcinoma ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest ◽  
Induced Apoptosis

Loss of p21 disrupts p14ARF-induced G1 cell cycle arrest but augments p14ARF induced apoptosis in human carcinoma cells

2005 ◽  
Vol 2005 (Fall) ◽  
Author(s):  
Philipp G. Hemmati ◽  
Guillaume Normand ◽  
Bernd Gillissen ◽  
Clarissa von Haefen ◽  
Jana Wendt ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Carcinoma Cells ◽  
Human Carcinoma ◽  
Cycle Arrest ◽  
G1 Cell Cycle Arrest ◽  
Induced Apoptosis

scholarly journals Cattleianal and Cattleianone: Two New Meroterpenoids from Psidium cattleianum Leaves and Their Selective Antiproliferative Action against Human Carcinoma Cells

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2891
Author(s):  
Engy A. Mahrous ◽  
Ahmed M. Al-Abd ◽  
Maha M. Salama ◽  
Magda M. Fathy ◽  
Fathy M. Soliman ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Annexin V ◽  
Carcinoma Cells ◽  
Cell Cycle Analysis ◽  
Breast Adenocarcinoma ◽  
Human Carcinoma ◽  
Psidium Cattleianum ◽  
Antiproliferative Action ◽  
Adenocarcinoma Cells ◽  
Ht 29

The Myrteacae family is known as a rich source of phloroglucinols, a group of secondary metabolites with notable biological activities. Leaves of Psidium cattleianum were extracted with chloroform: methanol 8:2 to target the isolation of phloroglucinol derivatives. Isolated compounds were characterized using different spectroscopic methods: nuclear magnetic resonance (NMR), ultra-violet (UV) and mass spectrometry (MS). Two new phloroglucinols were evaluated for cytotoxicity against a panel of six human cancer cell lines, namely colorectal adenocarcinoma cells (HT-29 and HCT-116); hepatocellular carcinoma cells (HepG-2); laryngeal carcinoma (Hep-2); breast adenocarcinoma cells (MCF7 and MDA-MB231), in addition to normal human melanocytes HFB-4. Additionally, cell cycle analysis and annexin-V/FITC-staining were used to gain insights into the mechanism of action of the isolated compounds. The new phloroglucinol meroterpenoids, designated cattleianal and cattleianone, showed selective antiproliferative action against HT-29 cells with IC50’s of 35.2 and 32.1 μM, respectively. Results obtained using cell cycle analysis and annexin-V/FITC-staining implicated both necrosis and apoptosis pathways in the selective cytotoxicity of cattleianal and cattleianone. Our findings suggest that both compounds are selective antiproliferative agents and support further mechanistic studies for phloroglucinol meroterpenoids as scaffolds for developing new selective chemotherapeutic agents.

Mitogenic response of human carcinoma cells to the liver-derived hormone FGF21

2016 ◽  
Vol 11 (03) ◽  
Author(s):  
L Berti ◽  
B Rädle ◽  
HU Häring ◽  
M Hrab((ebrevis)) de Angelis ◽  
H Staiger
Keyword(s):  
Carcinoma Cells ◽  
Mitogenic Response ◽  
Human Carcinoma
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