Effect of Telavancin on the Pharmacokinetics of the Cytochrome P450 3A Probe Substrate Midazolam: A Randomized, Double-Blind, Crossover Study in Healthy Subjects

2010 ◽  
Vol 30 (2) ◽  
pp. 136-143 ◽  
Author(s):  
Shekman L Wong ◽  
Michael R Goldberg ◽  
Charles H Ballow ◽  
Michael M Kitt ◽  
Steven L Barriere
Keyword(s):  
Cytochrome P450 ◽  
Crossover Study ◽  
Healthy Subjects ◽  
Cytochrome P450 3A ◽  
Double Blind ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

The Effects of Morphine–Neostigmine and Secretin Provocation on Pancreaticobiliary Morphology in Healthy Subjects: A Randomized, Double-blind Crossover Study Using Serial MRCP

2011 ◽  
Vol 35 (9) ◽  
pp. 2102-2109 ◽  
Author(s):  
Abeed H. Chowdhury ◽  
David J. Humes ◽  
Susan E. Pritchard ◽  
Luca Marciani ◽  
Penny A. Gowland ◽  
...  
Keyword(s):  
Crossover Study ◽  
Healthy Subjects ◽  
Double Blind ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

Carbachol induces headache, but not migraine-like attacks, in patients with migraine without aura

Cephalalgia ◽  
2009 ◽  
Vol 30 (3) ◽  
pp. 337-345 ◽  
Author(s):  
HW Schytz ◽  
T Wienecke ◽  
J Olesen ◽  
M Ashina
Keyword(s):  
Crossover Study ◽  
Middle Cerebral Artery ◽  
Healthy Subjects ◽  
Migraine Without Aura ◽  
Rating Scale ◽  
Superficial Temporal Artery ◽  
Temporal Artery ◽  
Double Blind ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

Carbachol induces headache in healthy subjects, but the migraine eliciting effect of carbachol has not previously been studied. We hypothesized that the cholinomimetic agonist carbachol would induce headache and migraine-like attacks in migraineurs. Carbachol (3 µg/kg) or placebo was randomly infused into 18 patients with migraine without aura in a double-blind crossover study. Headache was scored on a verbal rating scale from 0 to 10. Velocity in the middle cerebral artery (VMCA) and diameter of the superficial temporal artery (STA) were recorded. Fifteen patients experienced headache after carbachol compared with eight after placebo ( P = 0.039). There was no difference in incidence of migraine-like attacks after carbachol ( n = 8) compared with placebo ( n = 6) ( P = 0.687). Carbachol caused a decrease in VMCA ( P = 0.044), but no change in STA ( P = 0.089) compared with placebo. The study demonstrated that carbachol provocation is not a good model for experimental migraine.

Inhibition of Spontaneous Platelet Aggregation by Sulfinpyrazone

1979 ◽  
Vol 42 (02) ◽  
pp. 621-625 ◽  
Author(s):  
G G Nenci ◽  
G Agnelli ◽  
M Berrettini ◽  
P Parise ◽  
E Ballatori
Keyword(s):  
Platelet Aggregation ◽  
Crossover Study ◽  
Double Blind ◽  
Platelet Aggregability ◽  
Initiation Of Therapy ◽  
Spontaneous Platelet Aggregation ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

SummaryIn a randomized double-blind crossover study in 16 patients with enhanced in vitro spontaneous platelet aggregation, sulfinpyrazone proved to be effective in normalizing platelet aggregability within 4 days after initiation of therapy.

scholarly journals Erratum: Bosch-Sierra, N., et al. Effect of Fibre-Enriched Orange Juice on Postprandial Glycaemic Response and Satiety in Healthy Individuals: An Acute, Randomised, Placebo-Controlled, Double-Blind, Crossover Study. Nutrients 2019, 11, 3014

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 696
Author(s):  
Neus Bosch-Sierra ◽  
Roger Marqués-Cardete ◽  
Aránzazu Gurrea-Martínez ◽  
Carmen Grau-Del Valle ◽  
Clara Talens ◽  
...  
Keyword(s):  
Crossover Study ◽  
Orange Juice ◽  
Healthy Individuals ◽  
Glycaemic Response ◽  
Double Blind ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

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