Misoprostol Effects on Diclofenac-Induced Cardiorenal Changes in Salt-Sensitive Patients with Hypertension: The MEDIC Study

2008 ◽  
Vol 28 (7) ◽  
pp. 834-842 ◽  
Author(s):  
Mark A Munger ◽  
Stephanie F Gardner ◽  
Arasb Ateshkadi ◽  
Gary M Rabetoy ◽  
Yoursi M Barri ◽  
...  
Keyword(s):  
Medic Study

scholarly journals Diagnostic and Prognostic Implications of Endotoxemia in Critical Illness: Results of the MEDIC Study

2004 ◽  
Vol 190 (3) ◽  
pp. 527-534 ◽  
Author(s):  
John C. Marshall ◽  
Debra Foster ◽  
Jean‐Louis Vincent ◽  
Deborah J. Cook ◽  
Jonathan Cohen ◽  
...  
Keyword(s):  
Critical Illness ◽  
Prognostic Implications ◽  
Medic Study

scholarly journals Methicillin-Resistant Staphylococcus aureus Eradication and Decolonization in Children Study (Part 1): Development of a Decolonization Toolkit With Patient and Parent Advisors

10.2196/14974 ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. e14974 ◽  
Author(s):  
Courtney M Moore ◽  
Sarah E Wiehe ◽  
Dustin O Lynch ◽  
Gina EM Claxton ◽  
Matthew P Landman ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Skin Infection ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
High Rate ◽  
Healthy Children ◽  
Surgical Incision ◽  
Incision And Drainage ◽  
Methicillin Resistant ◽  
Study Participants ◽  
Medic Study

Background Community-acquired methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infections affect many healthy children. A significant number of these children are hospitalized and require surgical incision and drainage (I&D). Once sent home, these children and families are asked to complete burdensome home decolonization and hygiene procedures in an effort to prevent the high rate of recurrent infections. Objective This component of the Methicillin-resistant Staphylococcus aureus Eradication and Decolonization in Children (MEDiC) study aimed to develop a toolkit to assist MEDiC study participants in completing MRSA decolonization and hygiene procedures at home (the MEDiC kit). Methods In all, 5 adolescents (aged 10-18 years) who had undergone an I&D procedure for a skin infection and 11 parents of children who had undergone an I&D procedure for a skin infection were engaged in a 4-hour group workshop using a human-centered design approach. The topics covered in this workshop and analyzed for this paper were (1) attitudes about MRSA decolonization procedures and (2) barriers to the implementation of MRSA decolonization and hygiene procedures. The team analyzed the audio and artifacts created during the workshop and synthesized their findings to inform the creation of the MEDiC kit. Results The workshop activities uncovered barriers to successful completion of the decolonization and hygiene procedures: lack of step-by-step instruction, lack of proper tools in the home, concerns about adverse events, lack of control over some aspects of the hygiene procedures, and general difficulty coordinating all the procedures. Many of these could be addressed as part of the MEDiC kit. In addition, the workshop revealed that effective communication about decolonization would have to address concerns about the effects of bleach, provide detailed information, give reasons for the specific decolonization and hygiene protocol steps, and include step-by-step instructions (preferably through video). Conclusions Through direct engagement with patients and families, we were able to better understand how to support families in implementing MRSA decolonization and hygiene protocols. In addition, we were able to better understand how to communicate about MRSA decolonization and hygiene protocols. With this knowledge, we created a robust toolkit that uses patient-driven language and visuals to help support patients and families through the implementation of these protocols. Trial Registration ClinicalTrials.gov NCT02127658; https://clinicaltrials.gov/ct2/show/NCT02127658

scholarly journals Methicillin-Resistant Staphylococcus aureus Eradication and Decolonization in Children Study (Part 1): Development of a Decolonization Toolkit With Patient and Parent Advisors (Preprint)

2019 ◽  
Author(s):  
Courtney M Moore ◽  
Sarah E Wiehe ◽  
Dustin O Lynch ◽  
Gina EM Claxton ◽  
Matthew P Landman ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Skin Infection ◽  
High Rate ◽  
Healthy Children ◽  
Children And Families ◽  
Surgical Incision ◽  
Incision And Drainage ◽  
Methicillin Resistant ◽  
Study Participants ◽  
Medic Study

BACKGROUND Community-acquired methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) skin and soft tissue infections affect many healthy children. A significant number of these children are hospitalized and require surgical incision and drainage (I&amp;D). Once sent home, these children and families are asked to complete burdensome home decolonization and hygiene procedures in an effort to prevent the high rate of recurrent infections. OBJECTIVE This component of the Methicillin-resistant <i>Staphylococcus aureus</i> Eradication and Decolonization in Children (MEDiC) study aimed to develop a toolkit to assist MEDiC study participants in completing MRSA decolonization and hygiene procedures at home (the MEDiC kit). METHODS In all, 5 adolescents (aged 10-18 years) who had undergone an I&amp;D procedure for a skin infection and 11 parents of children who had undergone an I&amp;D procedure for a skin infection were engaged in a 4-hour group workshop using a human-centered design approach. The topics covered in this workshop and analyzed for this paper were (1) attitudes about MRSA decolonization procedures and (2) barriers to the implementation of MRSA decolonization and hygiene procedures. The team analyzed the audio and artifacts created during the workshop and synthesized their findings to inform the creation of the MEDiC kit. RESULTS The workshop activities uncovered barriers to successful completion of the decolonization and hygiene procedures: lack of step-by-step instruction, lack of proper tools in the home, concerns about adverse events, lack of control over some aspects of the hygiene procedures, and general difficulty coordinating all the procedures. Many of these could be addressed as part of the MEDiC kit. In addition, the workshop revealed that effective communication about decolonization would have to address concerns about the effects of bleach, provide detailed information, give reasons for the specific decolonization and hygiene protocol steps, and include step-by-step instructions (preferably through video). CONCLUSIONS Through direct engagement with patients and families, we were able to better understand how to support families in implementing MRSA decolonization and hygiene protocols. In addition, we were able to better understand how to communicate about MRSA decolonization and hygiene protocols. With this knowledge, we created a robust toolkit that uses patient-driven language and visuals to help support patients and families through the implementation of these protocols. CLINICALTRIAL ClinicalTrials.gov NCT02127658; https://clinicaltrials.gov/ct2/show/NCT02127658

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