scholarly journals Red ginseng polysaccharide alleviates cytotoxicity and promotes anti-inflammatory activity of ginsenosides

2021 ◽  
Author(s):  
Hoon KIM ◽  
Sung Min CHO ◽  
Woo Jung KIM ◽  
Ki-Bae HONG ◽  
Hyung Joo SUH ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Red Ginseng ◽  
Ginseng Polysaccharide ◽  
Anti Inflammatory

scholarly journals Effect of cultivation ages on anti-inflammatory activity of a new type of red ginseng

2021 ◽  
Vol 136 ◽  
pp. 111280
Author(s):  
Xin-fang Xu ◽  
Wen-jia Qu ◽  
Zhe Jia ◽  
Ting Han ◽  
Meng-nan Liu ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Red Ginseng ◽  
New Type ◽  
Anti Inflammatory

ATF-2/CREB/IRF-3-targeted anti-inflammatory activity of Korean red ginseng water extract

2014 ◽  
Vol 154 (1) ◽  
pp. 218-228 ◽  
Author(s):  
Yanyan Yang ◽  
Woo Seok Yang ◽  
Tao Yu ◽  
Gi-Ho Sung ◽  
Kye Won Park ◽  
...  
Keyword(s):  
Water Extract ◽  
Inflammatory Activity ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Anti Inflammatory

scholarly journals Insight Into Polysaccharides From Panax ginseng C. A. Meyer in Improving Intestinal Inflammation: Modulating Intestinal Microbiota and Autophagy

2021 ◽  
Vol 12 ◽  
Author(s):  
Dandan Wang ◽  
Shuai Shao ◽  
Yanqiu Zhang ◽  
Daqing Zhao ◽  
Mingxing Wang
Keyword(s):  
Panax Ginseng ◽  
Intestinal Inflammation ◽  
Therapeutic Potential ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Inflammatory Activity ◽  
Experimental Systems ◽  
Therapeutic Mechanism ◽  
Ginseng Polysaccharide ◽  
Anti Inflammatory

Polysaccharides from Panax ginseng C. A. Meyer (P. ginseng) are the main active component of P. ginseng and exhibit significant intestinal anti-inflammatory activity. However, the therapeutic mechanism of the ginseng polysaccharide is unclear, and this hinders the application for medicine or functional food. In this study, a polysaccharide was isolated from P. ginseng (GP). The primary structure and morphology of the GP were studied by HPLC, FT-IR spectroscopy, and scanning electron microscopy (SEM). Further, its intestinal anti-inflammatory activity and its mechanism of function were evaluated in experimental systems using DSS-induced rats, fecal microbiota transplantation (FMT), and LPS-stimulated HT-29 cells. Results showed that GP modulated the structure of gut microbiota and restored mTOR-dependent autophagic dysfunction. Consequently, active autophagy suppressed inflammation through the inhibition of NF-κB, oxidative stress, and the release of cytokines. Therefore, our research provides a rationale for future investigations into the relationship between microbiota and autophagy and revealed the therapeutic potential of GP for inflammatory bowel disease.

scholarly journals Anti-Inflammatory Activity of Rg3-Enriched Korean Red Ginseng Extract in Murine Model of Sepsis

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Evelyn Saba ◽  
Dahye Jeong ◽  
Muhammad Irfan ◽  
Yuan Yee Lee ◽  
Sang-Joon Park ◽  
...  
Keyword(s):  
Septic Shock ◽  
Inflammatory Activity ◽  
Raw 264.7 Cells ◽  
No Production ◽  
Therapeutic Effects ◽  
Red Ginseng ◽  
Ginseng Extract ◽  
Mapk Pathways ◽  
Proinflammatory Mediators ◽  
Anti Inflammatory

Ginseng has therapeutic effects on various bodily disorders ranging from minor inflammation to major cardiovascular diseases. In our study, we explored the anti-inflammatory effects of Rg3-enriched red ginseng extract (Rg3-RGE), a ginsenoside belonging to the panaxadiol group. We employed nitric oxide assay (NO) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR), western blot, and hematoxylin and eosin staining (H&E) to elucidate the anti-inflammatory activity of Rg3-RGE. Rg3-RGE potently suppressed NO production in the murine macrophage cell line, RAW 264.7 cells, without any cytotoxicity across dosages. Additionally, it inhibited the mRNA expression of proinflammatory mediators and cytokines like iNOS, COX-2, IL-1β, IL-6, and TNF-α. Moreover it also inhibited the levels of malondialdehyde levels in serum of septic shock mice. Immunoblot analysis showed that Rg3-RGE induced anti-inflammatory signal transduction via the NF-κB and MAPK pathways. A remarkable attenuation of inflammation by oral treatment with Rg3-RGE in mice was observed in the survival study. The in vivo study using a septic shock mouse model also showed similar results as the in vitro study. Our findings suggest that Rg3-RGE can potentially be a potent anti-inflammatory agent that likely mediates its anti-inflammatory effects via the NF-κB and MAPK pathways.

Anti-platelet and anti-inflammatory activity of Plumbago zeylanicus (Pz), Phyllanthus emblica (Pe) and their combination

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
DA Uchil ◽  
SK Kamat ◽  
SS Menon ◽  
AM Scindia ◽  
GK Dang ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Phyllanthus Emblica ◽  
Anti Inflammatory

A new flavonol with anti-inflammatory activity from Boldoa purpurascens Cav.

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
DM González Mosquera ◽  
A Kilonda ◽  
S Toppet ◽  
F Compernolle ◽  
W Dehaen ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Anti Inflammatory

Isolation characterization and anti-inflammatory activity of Rhaphiostylis beninensis Planch. Ex Benth (Icacinaceae)

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
J Ofeimun ◽  
B Ayinde ◽  
I Igbe ◽  
MI Choudhary ◽  
I Husain ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Anti Inflammatory

Cytotoxic and anti-inflammatory activity of diarylbutane lignans from the bark of Bursera ariensis

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
ME Acevedo-Quiroz ◽  
LP Álvarez Berber ◽  
S Marquina Bahena ◽  
A León Cabrera ◽  
A Cardoso Taketa ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Anti Inflammatory
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