scholarly journals Vitamin D alleviates skeletal muscle loss and insulin resistance by inducing vitamin D receptor expression and regulating the AMPK/SIRT1 signaling pathway in mice

2021 ◽  
Author(s):  
Aijuan LI ◽  
Pengcheng SHEN ◽  
Sijia LIU ◽  
Jiao WANG ◽  
Jingru ZENG ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Vitamin D ◽  
Signaling Pathway ◽  
Vitamin D Receptor ◽  
Receptor Expression ◽  
Muscle Loss ◽  
Skeletal Muscle Loss

p38 MAPK signaling pathway is involved in butyrate-induced vitamin D receptor expression

2004 ◽  
Vol 324 (4) ◽  
pp. 1220-1226 ◽  
Author(s):  
Carolin Daniel ◽  
Oliver Schröder ◽  
Nadine Zahn ◽  
Tanja Gaschott ◽  
Jürgen Stein
Keyword(s):  
Vitamin D ◽  
Signaling Pathway ◽  
P38 Mapk ◽  
Vitamin D Receptor ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Receptor Expression

scholarly journals 1,25(OH)2Vitamin D3 Stimulates Myogenic Differentiation by Inhibiting Cell Proliferation and Modulating the Expression of Promyogenic Growth Factors and Myostatin in C2C12 Skeletal Muscle Cells

Endocrinology ◽  
2011 ◽  
Vol 152 (8) ◽  
pp. 2976-2986 ◽  
Author(s):  
Leah A. Garcia ◽  
Keisha K. King ◽  
Monica G. Ferrini ◽  
Keith C. Norris ◽  
Jorge N. Artaza
Keyword(s):  
Skeletal Muscle ◽  
Vitamin D ◽  
Cell Proliferation ◽  
Vitamin D Receptor ◽  
Myogenic Differentiation ◽  
Receptor Expression ◽  
Negative Regulator ◽  
Muscle Performance ◽  
Rt Pcr ◽  
C2c12 Myoblasts

Skeletal muscle wasting is an important public health problem associated with aging, chronic disease, cancer, kidney dialysis, and HIV/AIDS. 1,25-Dihydroxyvitamin D (1,25-D3), the active form of vitamin D, is widely recognized for its regulation of calcium and phosphate homeostasis in relation to bone development and maintenance and for its calcemic effects on target organs, such as intestine, kidney, and parathyroid glands. Emerging evidence has shown that vitamin D administration improves muscle performance and reduces falls in vitamin D-deficient older adults. However, little is known of the underlying mechanism or the role 1,25-D3 plays in promoting myogenic differentiation at the cellular and/or molecular level. In this study, we examined the effect of 1,25-D3 on myoblast cell proliferation, progression, and differentiation into myotubes. C2C12 myoblasts were treated with 1,25-D3 or placebo for 1, 3, 4, 7, and 10 d. Vitamin D receptor expression was analyzed by quantitative RT-PCR, Western blottings and immunofluorescence. Expression of muscle lineage, pro- and antimyogenic, and proliferation markers was assessed by immunocytochemistry, PCR arrays, quantitative RT-PCR, and Western blottings. Addition of 1,25-D3 to C2C12 myoblasts 1) increased expression and nuclear translocation of the vitamin D receptor, 2) decreased cell proliferation, 3) decreased IGF-I expression, and 4) promoted myogenic differentiation by increasing IGF-II and follistatin expression and decreasing the expression of myostatin, the only known negative regulator of muscle mass, without changing growth differentiation factor 11 expression. This study identifies key vitamin D-related molecular pathways for muscle regulation and supports the rationale for vitamin D intervention studies in select muscle disorder conditions.

scholarly journals Evidence for Vitamin D Receptor Expression and Direct Effects of 1α,25(OH)2D3 in Human Skeletal Muscle Precursor Cells

Endocrinology ◽  
2016 ◽  
Vol 157 (1) ◽  
pp. 98-111 ◽  
Author(s):  
Karl Olsson ◽  
Amarjit Saini ◽  
Anna Strömberg ◽  
Seher Alam ◽  
Mats Lilja ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Human Skeletal Muscle ◽  
Precursor Cells ◽  
Receptor Expression ◽  
Direct Effects ◽  
Muscle Precursor ◽  
Muscle Precursor Cells

The vitamin D receptor expression in skeletal muscle of women with distal radius fracture

2018 ◽  
Vol 13 (1) ◽  
Author(s):  
Kahyun Kim ◽  
Hyun Sik Gong ◽  
Jae-Young Lim ◽  
Jong Hee Kim ◽  
Goo Hyun Baek
Keyword(s):  
Skeletal Muscle ◽  
Vitamin D ◽  
Distal Radius Fracture ◽  
Distal Radius ◽  
Vitamin D Receptor ◽  
Receptor Expression ◽  
Radius Fracture

scholarly journals Vitamin D and Skeletal Muscle Loss

2016 ◽  
Vol 1 (2) ◽  
Author(s):  
Gustavo D Pimentel ◽  
Renata C Fernandes ◽  
Maria CD Vega
Keyword(s):  
Skeletal Muscle ◽  
Vitamin D ◽  
Muscle Loss ◽  
Skeletal Muscle Loss

P12. Vitamin D receptor expression and monocyte differentiation

Bone ◽  
1992 ◽  
Vol 13 (3) ◽  
pp. 278
Author(s):  
M. Hewison ◽  
R. Walker ◽  
J.L.H. O'Riordan
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Receptor Expression ◽  
Monocyte Differentiation

Time course of skeletal muscle loss and oxidative stress in rats with walker 256 solid tumor

2010 ◽  
Vol 42 (6) ◽  
pp. 950-958 ◽  
Author(s):  
Flávia A. Guarnier ◽  
Alessandra L. Cecchini ◽  
Andréia A. Suzukawa ◽  
Ana Leticia G.C. Maragno ◽  
Andréa N.C. Simão ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Solid Tumor ◽  
Time Course ◽  
Muscle Loss ◽  
Skeletal Muscle Loss ◽  
Walker 256 ◽  
And Oxidative Stress
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