scholarly journals The effect of dexmedetomidine on gastric ischemia reperfusion injury in rats. Biochemical and histopathological evaluation

2021 ◽  
Vol 36 (1) ◽  
Author(s):  
Ufuk Kuyrukluyildiz ◽  
Leman Acun Delen ◽  
Didem Onk ◽  
Gulce Naz Yazici ◽  
Mine Gulaboglu ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Histopathological Evaluation ◽  
Gastric Ischemia

scholarly journals Benidipine can prevent liver ischemia reperfusion injury in rats: a biochemical and histopathological evaluation

2019 ◽  
Vol 33 (1) ◽  
pp. 1645-1652
Author(s):  
Orhan Cimen ◽  
Hüseyin Eken ◽  
Ferda Keskin Cimen ◽  
Asli Ozbek Bilgin ◽  
Kamil Pehlivanoglu ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Liver Ischemia ◽  
Histopathological Evaluation

scholarly journals Terminalia catappa L. infusion accelerates the healing process of gastric ischemia-reperfusion injury in rats

2020 ◽  
Vol 256 ◽  
pp. 112793
Author(s):  
Rie Ohara ◽  
Larissa Lucena Périco ◽  
Vinicius Peixoto Rodrigues ◽  
Gabriela Bueno ◽  
Ana Caroline Zanatta ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Healing Process ◽  
Terminalia Catappa ◽  
Gastric Ischemia

scholarly journals Effect of H2S on gastric ischemia-reperfusion injury in rats

2018 ◽  
Vol 26 (24) ◽  
pp. 1448-1454
Author(s):  
Jie Cui ◽  
Ji-He Zou ◽  
Lei Liu ◽  
Yue Shi ◽  
Wei-Li Qiao ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Gastric Ischemia

Polymorphonuclear leukocyte infiltration into gastric mucosa after ischemia-reperfusion

1994 ◽  
Vol 266 (1) ◽  
pp. G48-G54 ◽  
Author(s):  
F. J. Andrews ◽  
C. Malcontenti-Wilson ◽  
P. E. O'Brien
Keyword(s):  
Gastric Mucosa ◽  
Reperfusion Injury ◽  
Polymorphonuclear Leukocytes ◽  
Ischemia Reperfusion Injury ◽  
Tissue Injury ◽  
Ischemia Reperfusion ◽  
Mucosal Injury ◽  
Immunoperoxidase Staining ◽  
Immunoperoxidase Technique ◽  
Gastric Ischemia

Polymorphonuclear leukocytes (PMN) have been implicated in the pathogenesis of ischemia-reperfusion injury. The objective of this study was to investigate PMN infiltration and distribution within the gastric mucosa of rats subjected to 30 min gastric ischemia followed by reperfusion. Sections of mucosa were stained for PMN using an immunoperoxidase technique, and injury was assessed by quantitative histology. In control animals, there were 4 +/- 2 PMN/mm2 in the superficial and 9 +/- 4 PMN/mm2 in the deep mucosa. This increased significantly to 67 +/- 9 PMN/mm2 (P < 0.05) and 160 +/- 53 PMN/mm2 (P < 0.01) respectively at 15 min of reperfusion. The percentage of these PMN which were extravasated was 83 +/- 4% in the superficial mucosa and 82 +/- 4% in the deep mucosa (P < 0.001 compared with control levels of 0% in superficial and 10% in deep mucosa). Significant PMN infiltration occurred before full expression of mucosal injury and treatment of rats with anti-PMN antisera blocked reperfusion injury (treated 10.7 +/- 1.4% mucosa damaged, controls 33.5 +/- 2.4%; P < 0.001). Treatment with allopurinol (100 mg/kg) significantly reduced the number of infiltrating PMN (superficial 7 +/- 1/mm2, deep 16 +/- 2/mm2; P < 0.01) and the percentage of extravasating PMN (superficial 40 +/- 10%, deep 30 +/- 15%; P < 0.01) while also significantly reducing tissue injury (21.9 +/- 1.9% mucosa damaged, P < 0.01 compared with controls). We conclude that the immunoperoxidase staining provides a simple means of identifying PMN in histological sections. Furthermore, our results support a role for PMN in gastric ischemia-reperfusion injury.

Melatonin protects against gastric ischemia-reperfusion injury in rats

1997 ◽  
Vol 23 (2) ◽  
pp. 47-52 ◽  
Author(s):  
Catalina Alarcón Lastra ◽  
Juan Cabeza ◽  
Virginia Motilva ◽  
Maria J. Martin
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Gastric Ischemia
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