scholarly journals The meaning of cognitive dysfunction in bipolar disorder: a risk factor or a specific form of dementia?

2018 ◽  
Vol 45 (5) ◽  
pp. 135-135
Author(s):  
Cássio Silveira de Jesús ◽  
Marlos Vasconcelos Rocha ◽  
Ângela Miranda-Scippa
Keyword(s):  
Bipolar Disorder ◽  
Risk Factor ◽  
Cognitive Dysfunction ◽  
Specific Form

Cognitive Dysfunction as a Symptom Dimension Across Major Psychiatric Disorders

2019 ◽  
pp. 35-44
Author(s):  
Zihang Pan ◽  
Roger S. McIntyre
Keyword(s):  
Bipolar Disorder ◽  
Major Depressive Disorder ◽  
Psychiatric Disorders ◽  
Cognitive Dysfunction ◽  
Cognitive Deficits ◽  
Functional Disability ◽  
Cognitive Symptoms ◽  
Compelling Evidence ◽  
Psychiatric Illnesses ◽  
Neurobiological Substrates

Cognitive dysfunction is a symptom domain across multiple psychiatric disorders. Cognitive deficits in individuals with major depressive disorder (MDD) and bipolar disorder (BD) are significant contributors to global occupational and functional disability. The subdomains of learning and memory, executive function, processing speed, and attention and concentration are significantly impaired in individuals with MDD and BD. Treatment outcomes of cognitive symptoms with first-line agents have been suboptimal. Neuroinflammatory pathways are hypothesized to play key roles in the pathoaetiology of cognitive symptoms in MDD and BD. There is compelling evidence to suggest that elevation of systemic proinflammatory cytokines is involved in neurotoxicity, apoptosis, and aberrant neurocircuit function. These substrates offer opportunities to identify relevant biomarkers, refine treatment targets, and manage cognitive deficits across major psychiatric illnesses. This chapter provides an overview of cognitive symptoms across MDD and BD and discusses potential neurobiological substrates contributing to cognitive dysfunction.

scholarly journals LDB2 locus disruption on 4p16.1 as a risk factor for schizophrenia and bipolar disorder

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Yasue Horiuchi ◽  
Tomoe Ichikawa ◽  
Tetsuo Ohnishi ◽  
Yoshimi Iwayama ◽  
Kazuya Toriumi ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Risk Factor ◽  
Psychiatric Disorder ◽  
Male Patient ◽  
De Novo ◽  
Missense Variant ◽  
Chromosome 4 ◽  
Lim Domain ◽  
Balanced Translocation ◽  
Gene Encoding

AbstractWe had previously reported the case of a male patient with schizophrenia, having de-novo balanced translocation. Here, we determined the exact breakpoints in chromosomes 4 and 13. The breakpoint within chromosome 4 was mapped to a region 32.6 kbp upstream of the LDB2 gene encoding Lim domain binding 2. Variant screening in LDB2 revealed a rare novel missense variant in patients with psychiatric disorder.

scholarly journals Elevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Timothy Hughes ◽  
Ida E. Sønderby ◽  
Tatiana Polushina ◽  
Lars Hansson ◽  
Asbjørn Holmgren ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Risk Factor ◽  
Elevated Expression ◽  
A Minor
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