scholarly journals Locomotor activity and histological changes observed in a mouse model of knee osteoarthritis

2020 ◽  
Vol 32 (6) ◽  
pp. 370-374
Author(s):  
Satoshi Kojima ◽  
Masanori Watanabe ◽  
Keiji Asada
Keyword(s):  
Locomotor Activity ◽  
Mouse Model ◽  
Knee Osteoarthritis ◽  
Histological Changes

scholarly journals Lack of association between acupoint sensitization and microcirculatory structural changes in a mouse model of knee osteoarthritis: A pilot study

2019 ◽  
Vol 12 (6) ◽  
Author(s):  
Ning Ding ◽  
Xiaoxiao Liu ◽  
Ningbo Chen ◽  
Jing Jiang ◽  
Huangxuan Zhao ◽  
...  
Keyword(s):  
Pilot Study ◽  
Mouse Model ◽  
Knee Osteoarthritis ◽  
Structural Changes

scholarly journals Rescue of skeletal muscle α-actin–null mice by cardiac (fetal) α-actin

2009 ◽  
Vol 185 (5) ◽  
pp. 903-915 ◽  
Author(s):  
Kristen J. Nowak ◽  
Gianina Ravenscroft ◽  
Connie Jackaman ◽  
Aleksandra Filipovska ◽  
Stefan M. Davies ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Locomotor Activity ◽  
Mouse Model ◽  
Old Age ◽  
Knockout Mice ◽  
Skeletal Muscles ◽  
Pathological Features ◽  
Congenital Myopathies ◽  
Functional Differences ◽  
Mouse Lines

Skeletal muscle α-actin (ACTA1) is the major actin in postnatal skeletal muscle. Mutations of ACTA1 cause mostly fatal congenital myopathies. Cardiac α-actin (ACTC) is the major striated actin in adult heart and fetal skeletal muscle. It is unknown why ACTC and ACTA1 expression switch during development. We investigated whether ACTC can replace ACTA1 in postnatal skeletal muscle. Two ACTC transgenic mouse lines were crossed with Acta1 knockout mice (which all die by 9 d after birth). Offspring resulting from the cross with the high expressing line survive to old age, and their skeletal muscles show no gross pathological features. The mice are not impaired on grip strength, rotarod, or locomotor activity. These findings indicate that ACTC is sufficiently similar to ACTA1 to produce adequate function in postnatal skeletal muscle. This raises the prospect that ACTC reactivation might provide a therapy for ACTA1 diseases. In addition, the mouse model will allow analysis of the precise functional differences between ACTA1 and ACTC.

Proximal fibular osteotomy alleviates medial compartment knee osteoarthritis in a mouse model

2020 ◽  
Vol 44 (6) ◽  
pp. 1107-1113 ◽  
Author(s):  
Tian-Rui Wang ◽  
Hong-De Wang ◽  
Wei Chen ◽  
Teng-Bo Yu ◽  
Yan Qin ◽  
...  
Keyword(s):  
Mouse Model ◽  
Knee Osteoarthritis ◽  
Medial Compartment ◽  
Fibular Osteotomy

scholarly journals Gender-specific alteration of energy balance and circadian locomotor activity in the Crtc1 knockout mouse model of depression

2017 ◽  
Vol 7 (12) ◽  
Author(s):  
Clara Rossetti ◽  
Daniel Sciarra ◽  
Jean-Marie Petit ◽  
Chin B. Eap ◽  
Olivier Halfon ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Energy Balance ◽  
Mouse Model ◽  
Knockout Mouse ◽  
Knockout Mouse Model ◽  
Specific Alteration ◽  
Gender Specific

Molecular and histological changes following central retinal artery occlusion in a mouse model

2008 ◽  
Vol 87 (4) ◽  
pp. 327-333 ◽  
Author(s):  
Nitza Goldenberg-Cohen ◽  
Shimrit Dadon ◽  
Bat-Chen R. Avraham ◽  
Michal Kramer ◽  
Murat Hasanreisoglu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Central Retinal Artery Occlusion ◽  
Retinal Artery Occlusion ◽  
Artery Occlusion ◽  
Central Retinal Artery ◽  
Histological Changes ◽  
Retinal Artery
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