What is the current place of azoles in allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitization

2012 ◽  
Vol 6 (4) ◽  
pp. 363-371 ◽  
Author(s):  
Ritesh Agarwal
Keyword(s):  
Severe Asthma ◽  
Allergic Bronchopulmonary Aspergillosis ◽  
Fungal Sensitization

scholarly journals Allergic bronchopulmonary aspergillosis in patients with asthma: Results of a prospective study

2017 ◽  
Vol 89 (8) ◽  
pp. 13-16 ◽  
Author(s):  
Ya I Kozlova ◽  
E V Frolova ◽  
L V Filippova ◽  
A E Uchevatkina ◽  
O V Aak ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Allergic Bronchopulmonary Aspergillosis ◽  
Specific Ige ◽  
Skin Tests ◽  
Asthmatic Patients ◽  
Fungal Allergens ◽  
Allergenic Fungi ◽  
Fungal Allergen ◽  
A Prospective Study ◽  
Fungal Sensitization

Aim. To estimate the frequency of fungal sensitization and the incidence of allergic bronchopulmonary aspergillosis (ABPA) in asthmatic patients. Subjects and methods. A total of 140 asthmatic patients were examined. They underwent allergologic (skin tests for fungal allergens, estimation of total and fungal allergen-specific IgE levels) and mycological (microscopy and inoculation of respiratory biosubstrates) examinations. Chest computed tomography, when indicated, was done. A group of patients with ABPA and that of patients with severe asthma and fungal sensitization were identified. Results. The frequency of fungal sensitization in asthmatic patients was 36%; the main allergenic fungi were Aspergillus and Alternaria. The incidence of ABPA was as high as 4% in the patients with asthma and 11% in those with severe asthma and fungal sensitization. Conclusion. The given current diagnostic criteria will assist practitioners to identify ABPA, to prevent its progression, and to initiate specific anti-inflammatory and antifungal therapy in due time.

The effects of antifungal therapy on severe asthma with fungal sensitization and allergic bronchopulmonary aspergillosis

Respirology ◽  
2009 ◽  
Vol 14 (8) ◽  
pp. 1121-1127 ◽  
Author(s):  
Alessandro C. PASQUALOTTO ◽  
Georgina POWELL ◽  
Robert NIVEN ◽  
David W. DENNING
Keyword(s):  
Severe Asthma ◽  
Antifungal Therapy ◽  
Allergic Bronchopulmonary Aspergillosis ◽  
Fungal Sensitization

scholarly journals Genetic susceptibility to severe asthma with fungal sensitization

2017 ◽  
Vol 44 (3) ◽  
pp. 93-106 ◽  
Author(s):  
N. L. Overton ◽  
A. Simpson ◽  
P. Bowyer ◽  
D. W. Denning
Keyword(s):  
Genetic Susceptibility ◽  
Severe Asthma ◽  
Fungal Sensitization

CHIT1 Mutations: Genetic Risk Factor for Severe Asthma With Fungal Sensitization?

PEDIATRICS ◽  
2010 ◽  
Vol 126 (4) ◽  
pp. e982-e985 ◽  
Author(s):  
A. G. Vicencio ◽  
G. L. Chupp ◽  
K. Tsirilakis ◽  
X. He ◽  
A. Kessel ◽  
...  
Keyword(s):  
Risk Factor ◽  
Severe Asthma ◽  
Genetic Risk ◽  
Genetic Risk Factor ◽  
Fungal Sensitization

scholarly journals BASOPHILE ACTIVATION TEST FOR THE DIAGNOSTICS OF FUNGAL SENSITIZATION IN THE PATIENTS WITH CYSTIC FIBROSIS

2019 ◽  
Vol 21 (5) ◽  
pp. 919-928
Author(s):  
Ya. I. Kozlova ◽  
E. V. Frolova ◽  
A. E. Uchevatkina ◽  
L. V. Filippova ◽  
O. V. Aak ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Stimulation Index ◽  
Allergic Bronchopulmonary Aspergillosis ◽  
Basophil Activation Test ◽  
Specific Ige ◽  
Basophil Activation ◽  
Total Ige ◽  
Activation Test ◽  
Fungal Allergens ◽  
Fungal Sensitization

Aspergillus fumigatus colonization in the patients with cystic fibrosis (CF) may cause sensitization against A. fumigatus and/or allergic bronchopulmonary aspergillosis (ABPA), which significantly worsens the course of underlying disease. At the present time, new diagnostic tests are searched for detection of fungal sensitization in these patients. The aim of this work was to evaluate an opportunity of application of basophile activation test with A. fumigatus allergen in vitro using flow cytometry, aiming for identification of fungal sensitization in the CF patients. The study included 190 patients with CF aged 1 to 37 years. All the patients underwent common allergy screening (skin tests with fungal allergens, determination of serum levels of total IgE and specific IgE for the fungal allergens), and mycological examination (microscopy and culture of respiratory substrates). Computed tomography of the chest was performed upon clinical indications. The basophil activation test with the A. fumigatus allergen was performed in 10 CF patients with ABPA, and 10 CF patients without ABPA, in addition to the standard allergological examination. Frequency of sensitization to A. fumigatus in the patients with cystic fibrosis was 27%, the incidence of allergic bronchopulmonary aspergillosis was 5.7%. The number of eosinophils, total IgE and specific IgE levels in CF patients with ABPA were significantly higher than in CF patients without ABPA. In blood of the ABPA patients we have identified 68.5 (52.5-81.5%) of basophilic leukocytes activated by A. fumigatus allergen, with a stimulation index of 17.07 (10.30-27.70). In appropriate comparison group, the stimulation index did not exceed 1.5 (p = 0.000). Direct positive correlation between the levels of specific IgE to A. fumigatus and the number of basophils activated by A. fumigatus allergens was revealed (r = 0.77; р < 0.05). FVC values and the body mass index in CF patients with ABPA were significantly lower when compared with the patients without fungal sensitization. Introduction of the basophil activation test, along with standard techniques, may enable a more differentiated assessment of ABPA development in CF patients. Timely detection of associations between A. fumigatus sensitization and clinical status of CF patients will facilitate early and effective administration of specific therapy.

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