Extrapulmonary comorbidities in chronic obstructive pulmonary disease: state of the art

2011 ◽  
Vol 5 (5) ◽  
pp. 647-662 ◽  
Author(s):  
Anant RC Patel ◽  
John R Hurst
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
State Of The Art ◽  
Disease State ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

PP128 Quantifying The Relative Importance Of Chronic Obstructive Pulmonary Disease Symptoms To Patients

2019 ◽  
Vol 35 (S1) ◽  
pp. 61-61
Author(s):  
Nigel S. Cook ◽  
Konstantinos Kostikas ◽  
Beyza Oezel ◽  
Sophi Tatlock ◽  
Katie Mycock ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
United Kingdom ◽  
Pulmonary Disease ◽  
The United States ◽  
Disease State ◽  
Chronic Obstructive ◽  
Relative Importance ◽  
Obstructive Pulmonary Disease ◽  
The United Kingdom ◽  
Trade Offs

IntroductionPrevious qualitative research analyzing social media and online community discussions highlighted the symptomatic burden of cough and mucus (sputum), alongside shortness of breath, in patients with chronic obstructive pulmonary disease (COPD). The objective of this study was to determine the relative importance of these symptoms and their consequences (for example, disturbed sleep) to COPD patients, compared with conventional COPD endpoints (lung function and exacerbations).MethodsA total of 1,050 patients (at least 40 years of age) with moderate to severe COPD or chronic bronchitis, and regular symptoms of cough and excess mucus production, are to be recruited through patient advocacy groups (PAGs) from five countries (Australia, France, Japan, the United Kingdom, and the United States; 150 to 400 patients per country). A discrete choice experiment was designed with input from clinical experts and the PAGs, plus scientific advice from the National Institute for Health and Care Excellence (NICE) in the United Kingdom. Patients’ preferences for the conditional relative importance of symptoms and impact of COPD will be quantified based on trade-offs they are willing to make among hypothetical COPD disease state profiles, described by differing attributes and levels. Hierarchical Bayesian analysis with effect-coding parameterization will be undertaken on the choice data to estimate (using Gibbs sampling) the relative value each respondent places on an attribute level.ResultsThe feedback from NICE informed the selection of screening criteria and the statistical analysis plan, as well as the inclusion of a health status measure, the EQ-5D-3L. Qualitative patient interviews and pilot testing of the attributes and levels grid have been completed, informing finalization of the online survey design.ConclusionsPatient preference studies evaluating the relative importance of symptom burden through assessment of disease state preference values are an important new form of patient-based evidence for informing value-based decision making in HTA. The present study should facilitate a more patient-centered approach to developing new treatments for and improving the care of patients with COPD.

Systemic concentrations of asymmetric dimethylarginine (ADMA) in chronic obstructive pulmonary disease (COPD): state of the art

Amino Acids ◽  
2018 ◽  
Vol 50 (9) ◽  
pp. 1169-1176 ◽  
Author(s):  
Angelo Zinellu ◽  
Alessandro G. Fois ◽  
Arduino A. Mangoni ◽  
Panagiotis Paliogiannis ◽  
Elisabetta Sotgiu ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Asymmetric Dimethylarginine ◽  
State Of The Art ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease
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