The virulence of pandemic influenza A (H1N1) 2009: an epidemiological perspective on the case–fatality ratio

2010 ◽  
Vol 4 (3) ◽  
pp. 329-338 ◽  
Author(s):  
Hiroshi Nishiura
Keyword(s):  
Pandemic Influenza ◽  
Influenza A ◽  
Case Fatality ◽  
Case Fatality Ratio ◽  
Influenza A H1n1

Adult intensive-care patients with 2009 pandemic influenza A(H1N1) infection

2010 ◽  
Vol 139 (8) ◽  
pp. 1202-1209 ◽  
Author(s):  
C. FUHRMAN ◽  
I. BONMARIN ◽  
D. BITAR ◽  
T. CARDOSO ◽  
N. DUPORT ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care ◽  
Antiviral Therapy ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Protective Factor ◽  
Severe Disease ◽  
Case Fatality ◽  
Icu Patients ◽  
Influenza A H1n1

SUMMARYIn France, the surveillance of hospitalized cases of pandemic influenza was implemented in July 2009 and restricted to intensive-care unit (ICU) patients in November. We described the characteristics of the 1065 adult patients admitted to ICUs and analysed risk factors for severe outcome (mechanical ventilation or death). Eighty-seven percent of cases were aged 15–64 years. The case-fatality ratio was 20%. The risk for severe outcome increased with age and obesity while this association was negative for chronic respiratory disease. Late antiviral therapy was associated with a severe outcome in ICU patients with risk factors (adjusted OR 2·0, 95% CI 1·4–3·0). This study confirms the considerable contribution of young adults to A(H1N1) 2009 mortality. It shows the role of obesity as an independent risk factor for severe disease, and of early antiviral therapy as a protective factor, at least in patients with risk factors.

scholarly journals The Time Required to Estimate the Case Fatality Ratio of Influenza Using Only the Tip of an Iceberg: Joint Estimation of the Virulence and the Transmission Potential

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Keisuke Ejima ◽  
Ryosuke Omori ◽  
Benjamin J. Cowling ◽  
Kazuyuki Aihara ◽  
Hiroshi Nishiura
Keyword(s):  
Influenza A ◽  
Case Fatality ◽  
Joint Estimation ◽  
Minimum Length ◽  
Public Health Response ◽  
Simple Method ◽  
Transmission Potential ◽  
Case Fatality Ratio ◽  
Influenza A H1n1 ◽  
Time Required

Estimating the case fatality ratio (CFR) of a novel strain of influenza virus during the early stage of the pandemic is one of key epidemiological tasks to be conducted as rapid research response. Past experience during the epidemics of severe acute respiratory syndrome (SARS) and influenza A (H1N1-2009) posed several technical challenges in estimating the CFR in real time. The present study aimed to develop a simple method to estimate the CFR based on readily available datasets, that is, confirmed cases and deaths, while addressing some of the known technical issues. To assess the reliability and validity of the proposed method, we examined the minimum length of time required for the assigned CFR to be included within the 95% confidence intervals and for the estimated CFR to be below a prespecified cut-off value by means of Monte Carlo simulations. Overall, the smaller the transmission potential was, the longer it took to compare the estimated CFR against the cut-off value. If policymaking and public health response have to be made based on the CFR estimate derived from the proposed method and readily available data, it should be noted that the successful estimation may take longer than a few months.

scholarly journals 2009 Influenza A (H1N1) in Panama: a disease affecting children with a benign course

2011 ◽  
Vol 5 (09) ◽  
pp. 664-668 ◽  
Author(s):  
Javier Nieto- Guevara ◽  
Nestor Sosa ◽  
Mariana Garcia ◽  
Alex Martinez ◽  
Marlene Castillo
Keyword(s):  
Pandemic Influenza ◽  
Influenza A ◽  
Case Fatality Rate ◽  
Case Fatality ◽  
Nasopharyngeal Swab ◽  
Fatality Rate ◽  
Female Ratio ◽  
Severe Acute Respiratory Infection ◽  
Influenza A H1n1 ◽  
Epidemiological Characteristics

Introduction: Pandemic Influenza A (H1N1) was identified as the major febrile respiratory illness worldwide during the year 2009.  We present a report of its clinical and epidemiological characteristics in children and adults in Panama.  Methodology: A descriptive study from the database of the Gorgas Memorial Institute is presented.   We included patients with severe acute respiratory infection in whom a nasopharyngeal swab was positive by real-time RT-PCR for 2009 Influenza A (H1N1) pandemic virus and negative for seasonal influenza A H1 and H3. Results: From 26 April 2009 to 11 January 2010, confirmed cases of pandemic 2009 Influenza A (H1N1) reached 806. The overall incident rate was 23.35 cases of pandemic influenza per 100,000 habitants, with the highest incidence found in the age group between 10 to 14 years of age (58.67 cases per 100,000 habitants).  The median age for the cases was 13 years (ages ranging from one day to 88 years) and 71% were from the Panama City Metropolitan Area.  The male/female ratio was 1:1 and 90% were managed as out-patients.   An influenza-like syndrome was the presenting diagnosis in 99% of the cases.  Fever and cough were the most frequent symptoms reported in all age groups. The case fatality rate was 0.3 cases per 100,000 habitants. Conclusion: The 2009 Influenza A (H1N1) outbreak affected mainly the pediatric population, had a low case fatality rate, and was the predominant virus circulating in Panama during the 2009/2010 flu season

National Surveillance for Reye Syndrome: A Five-Year Review

PEDIATRICS ◽  
1982 ◽  
Vol 70 (6) ◽  
pp. 895-900 ◽  
Author(s):  
Eugene S. Hurwitz ◽  
David B. Nelson ◽  
Cornelia Davis ◽  
David Morens ◽  
Lawrence B. Schonberger
Keyword(s):  
Influenza A ◽  
Age Groups ◽  
Case Fatality ◽  
Large Percentage ◽  
Influenza B ◽  
Reye Syndrome ◽  
National Surveillance ◽  
Case Fatality Ratio ◽  
The Past ◽  
Influenza A H1n1

National surveillance for Reye syndrome conducted during five years, including the period 1973-1974 and December 1976 through November 1980, has resulted in the reporting of more than 2,000 cases of Reye syndrome. The highest reported incidence of Reye syndrome occurred during years of primary influenza B and A (H1N1) activity; the reported incidence during one period of influenza A (H3N2) activity was somewhat lower. Regional outbreaks of Reye syndrome have been associated with influenza A (H1N1) and B but not with influenza A (H3N2). Cases of Reye syndrome in whites tend to be distributed throughout all age groups whereas a large percentage of cases in blacks have been reported in infants <1 year of age in three of the past four years. Nationally, there has been a decline in the case-fatality ratio in recent years.

scholarly journals Expression of Surfactant protein D (SP-D) distinguishes severe pandemic influenza A(H1N1) from COVID-19

2021 ◽  
Author(s):  
José Alberto Choreño-Parra ◽  
Luis Armando Jiménez-Álvarez ◽  
Gustavo Ramírez-Martínez ◽  
Alfredo Cruz-Lagunas ◽  
Mahima Thapa ◽  
...  
Keyword(s):  
Pandemic Influenza ◽  
Influenza A ◽  
Alveolar Epithelium ◽  
Surfactant Protein ◽  
High Serum ◽  
Surfactant Protein D ◽  
Diagnostic Challenge ◽  
Moderate Disease ◽  
Influenza A H1n1 ◽  
Novel Biomarkers

Abstract The differentiation of influenza and COVID-19 could constitute a diagnostic challenge during the ongoing winter due to their clinical similitude. Thus, novel biomarkers that enable distinguishing both diseases are required. Here, we evaluated whether the surfactant protein D (SP-D), a collectin produced at the alveolar epithelium with known immune properties, was useful to differentiate pandemic influenza A(H1N1) from COVID-19 in critically ill patients. Our results revealed high serum SP-D levels in severe pandemic influenza but not COVID-19 patients. This finding was validated in a separate cohort of mechanically ventilated COVID-19 patients who also showed low plasma SP-D levels. However, plasma SP-D levels did not distinguish seasonal influenza from COVID-19 in mild-to-moderate disease. Finally, we found that high serum SP-D levels were associated with mortality and renal failure among severe pandemic influenza cases. Thus, our studies have identified SP-D as a unique biomarker expressed during severe pandemic influenza but not COVID-19.

scholarly journals Ultrastructural and Histopathological Studies of 2009 Pandemic Influenza A (H1N1) Virus

2010 ◽  
Vol 16 (S2) ◽  
pp. 1122-1123
Author(s):  
CS Goldsmith ◽  
MG Metcalfe ◽  
W-J Shieh ◽  
DM Blau ◽  
DC Rollin ◽  
...  
Keyword(s):  
Pandemic Influenza ◽  
Influenza A ◽  
H1n1 Virus ◽  
Influenza A H1n1 ◽  
Histopathological Studies

Extended abstract of a paper presented at Microscopy and Microanalysis 2010 in Portland, Oregon, USA, August 1 – August 5, 2010.

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