Retrospective observational study of the management of multiple sclerosis patients with resistant spasticity in Spain: the ‘5E’ study

2011 ◽  
Vol 11 (2) ◽  
pp. 205-213 ◽  
Author(s):  
Rafael Arroyo ◽  
Carlos Vila ◽  
Steve Clissold
Keyword(s):  
Multiple Sclerosis ◽  
Observational Study ◽  
Retrospective Observational Study ◽  
Multiple Sclerosis Patients

A retrospective observational study of rituximab treatment in multiple sclerosis patients in Cyprus

2019 ◽  
Vol 131 (7) ◽  
pp. 486-489 ◽  
Author(s):  
Eleni Leonidou ◽  
Marios Pantzaris ◽  
Kleopas A. Kleopa ◽  
Maria A. Loizidou ◽  
Theodoros Kyriakides ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Observational Study ◽  
Retrospective Observational Study ◽  
Multiple Sclerosis Patients

scholarly journals Outcomes of pregnancy in Egyptian women with multiple sclerosis in the new treatment era: a multi-center retrospective observational study

2021 ◽  
Vol 57 (1) ◽  
Author(s):  
Ali Mahmoud Ahmed ◽  
Mohamed Al-Bahay M. G. Reda ◽  
Ahmed Hassan Elsheshiny
Keyword(s):  
Multiple Sclerosis ◽  
Observational Study ◽  
Exclusive Breastfeeding ◽  
Retrospective Observational Study ◽  
Third Trimester ◽  
Early Postpartum ◽  
Egyptian Women ◽  
History Of ◽  
New Treatment ◽  
The Relationship

Abstract Background Pregnancy is a recent growing issue in multiple sclerosis (MS) and the update in the diagnostic criteria of MS and introduction of many disease-modifying therapies (DMTs) may cause changes in the relationship between MS, pregnancy, and breastfeeding. This study aimed to investigate the effect of pregnancy and breastfeeding on MS and vice versa. A retrospective observational study was conducted to include MS women with a history of at least one pregnancy during the last 7 years. Data were collected from the archived files in addition to a self-administrating questionnaire. The annualized relapsing rate (ARR) was calculated before, during, and after pregnancy. Results We included 116 successful pregnancies from 93 MS women with mean age 32.74 ± 5.12 years. Interferon-beta was the commonly used DMT during and after pregnancy. Despite the ARR during the two years preceding the conception was 0.36 (95% CI 0.32–0.41), this rate was significantly decreased during first, second, and third trimester (0.07; 95% CI 0.04–0.15, 0.10; 95% CI 0.03–0.17, and 0.15; 95% CI 0.08–0.24, respectively; P-value < 0.001 in all). Furthermore, this ARR was significantly decreased during the first and last three months after delivery (0.27; 95% CI 0.16–0.39; P-value = 0.037, and 0.24; 95% CI 0.17–0.38; P-value = 0.023). Exclusive breastfeeding was associated with deceased risk of postpartum relapse, with HR 0.31 (95% CI 0.12–0.67; P = 0.002). Conclusions Pregnancy is protective from MS relapse, with a significant decrease of ARR from the pre-pregnancy period. Postpartum reactivation of the disease occurs from the third month after labor, rather than the early postpartum period. Exclusive breastfeeding for at least 2 months decreased the risk of postpartum relapse.

Evaluating the efficacy and safety of ZytuxTM (Rituximab, AryoGen pharmed) in Iranian multiple sclerosis patients: An observational study

2019 ◽  
Vol 36 ◽  
pp. 101419 ◽  
Author(s):  
Abdorreza Naser Moghadasi ◽  
Aala Darki ◽  
Peiman Masoumi ◽  
Seyedeh Nafiseh Hashemi ◽  
Fereshteh Ghadiri
Keyword(s):  
Multiple Sclerosis ◽  
Observational Study ◽  
Efficacy And Safety ◽  
Multiple Sclerosis Patients

scholarly journals The real-world effectiveness and safety of fingolimod in relapsing-remitting multiple sclerosis patients: An observational study

PLoS ONE ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. e0176174 ◽  
Author(s):  
Guillermo Izquierdo ◽  
Fátima Damas ◽  
Maria Dolores Páramo ◽  
Juan Luis Ruiz-Peña ◽  
Guillermo Navarro
Keyword(s):  
Multiple Sclerosis ◽  
Observational Study ◽  
Real World ◽  
The Real ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Multiple Sclerosis Patients ◽  
Relapsing Remitting Multiple Sclerosis
Sign in / Sign up

Export Citation Format

Share Document