Gene therapy for Parkinson’s disease: state-of-the-art treatments for neurodegenerative disease

2013 ◽  
Vol 13 (6) ◽  
pp. 695-705 ◽  
Author(s):  
Michael R Douglas
Keyword(s):  
Parkinson’S Disease ◽  
Gene Therapy ◽  
Parkinson's Disease ◽  
Neurodegenerative Disease ◽  
State Of The Art ◽  
Disease State

scholarly journals 200. Advancing a State of the Art Gene Therapy for Parkinson's Disease

2015 ◽  
Vol 23 ◽  
pp. S79-S80
Author(s):  
Romina Aron Badin ◽  
Katie Binley ◽  
Nadja Van Camp ◽  
Caroline Jan ◽  
Jean Gourlay ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Gene Therapy ◽  
Parkinson's Disease ◽  
State Of The Art

scholarly journals Next-Generation Gene Therapy for Parkinson’s Disease Using Engineered Viral Vectors

2021 ◽  
pp. 1-9
Author(s):  
Tomas Björklund ◽  
Marcus Davidsson
Keyword(s):  
Parkinson’S Disease ◽  
Gene Therapy ◽  
Parkinson's Disease ◽  
Clinical Trials ◽  
Genome Editing ◽  
Viral Vectors ◽  
State Of The Art ◽  
The State ◽  
Next Generation ◽  
Suitable Vector

Recent technological and conceptual advances have resulted in a plethora of exciting novel engineered adeno associated viral (AAV) vector variants. They all have unique characteristics and abilities. This review summarizes the development and their potential in treating Parkinson’s disease (PD). Clinical trials in PD have shown over the last decade that AAV is a safe and suitable vector for gene therapy but that it also is a vehicle that can benefit significantly from improvement in specificity and potency. This review provides a concise collection of the state-of-the-art for synthetic capsids and their utility in PD. We also summarize what therapeutical strategies may become feasible with novel engineered vectors, including genome editing and neuronal rejuvenation.

2.103 TECHNOLOGY AND PARKINSON'S DISEASE: STATE-OF-THE-ART AND TRENDS IN REMOTE MONITORING AND REHABILITATION

2012 ◽  
Vol 18 ◽  
pp. S102
Author(s):  
J. Cancela González ◽  
M. Pastorino ◽  
L. Pastor-Sanz ◽  
A.P. Gonzalez Marcos ◽  
M.T. Arredondo Waldmeyer
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Remote Monitoring ◽  
State Of The Art ◽  
Disease State

Molecular imaging of gene therapy. The future in Parkinson's disease therapy?

2005 ◽  
Vol 32 (S 4) ◽  
Author(s):  
A.H Jacobs ◽  
R Hilker ◽  
L Burghaus ◽  
W.D Heiss
Keyword(s):  
Parkinson’S Disease ◽  
Gene Therapy ◽  
Parkinson's Disease ◽  
Molecular Imaging ◽  
Disease Therapy ◽  
The Future
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