scholarly journals Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions

2012 ◽  
Vol 12 (5) ◽  
pp. 577-585 ◽  
Author(s):  
Roland Staud
Keyword(s):  
Chronic Pain ◽  
Pain Modulation ◽  
Endogenous Pain Modulation ◽  
Chronic Pain Conditions ◽  
Shared Characteristic

Recent Advances in Pain Research: Implications for Chronic Headache

Cephalalgia ◽  
2001 ◽  
Vol 21 (7) ◽  
pp. 765-769 ◽  
Author(s):  
TS Jensen
Keyword(s):  
Chronic Pain ◽  
Nervous System ◽  
Chronic Headache ◽  
Preventive Measures ◽  
Pain Modulation ◽  
New Information ◽  
Endogenous Pain Modulation ◽  
Plastic Changes ◽  
Chronic Pain Conditions ◽  
The Brain

Within the last 2 decades there has been an explosion in new information on mechanisms underlying pain. Unfortunately this information has not resulted in a similar improvement of our handling of patients with chronic pain including chronic musculoskeletal pain. Neuronal hyperexcitability, which apparently is a key phenomenon in many (if not all) types of chronic pain results in changes in the nervous system from the level of the peripheral nociceptor to the highest cortical centers in the brain. The neuronal plastic changes in chronic pain conditions makes the nociceptive system amenable for treatment with several traditional as well as untraditional types of interventions. Two treatment areas that seem worth exploring within chronic pain including headache concerns preventive measures and endogenous pain modulation.

REPRINTED WITH PERMISSION OF IASP – PAIN 160 (2019) 2679–2690: Conditioned pain modulation as a biomarker of chronic pain: a systematic review of its concurrent validity

Ból ◽  
2020 ◽  
Vol 21 (3) ◽  
pp. 1-15
Author(s):  
Carina Fernandes ◽  
Marina Pidal-Miranda ◽  
Noelia Samartin-Veiga ◽  
María T. Carrillo-de-la-Peña
Keyword(s):  
Systematic Review ◽  
Chronic Pain ◽  
Concurrent Validity ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Experimental Pain ◽  
Pain Modulation ◽  
Conditioned Pain Modulation ◽  
Pain Mechanisms ◽  
Chronic Pain Conditions

Conditioned pain modulation (CPM) is a promising psychophysical biomarker of central pain mechanisms because it significantly discriminates patients with chronic pain from healthy controls. Nevertheless, it is unclear in what extent CPM assessed experimentally is correlated with clinical manifestations of pain. To assess the concurrent validity of CPM, we performed a systematic review of the literature reporting correlations between CPM responses and pain intensity, disability, duration, and area in patients with different chronic pain conditions. We included 32 studies that altogether encompassed data from 1958 patients and provided 62 correlations. The majority of the results (69%) reported nonsignificant correlations between CPM efficiency and clinical manifestations of pain, whereas the remaining results showed a correlation between CPM reduction and worse clinical symptoms of pain. The modality of stimulation, the type of pain, and the stimulation site appear to be critical variables that influenced the pattern of results. Given that most of the studies were conducted with highly heterogeneous methodologies and unclear risk of bias, the findings highlight the need for future studies using standardized measures of clinical and experimental pain before considering CPM as a valid biomarker of pain. We discuss some guidelines to overcome the constraints in this promising line of research.

Offset analgesia identifies impaired endogenous pain modulation in pediatric chronic pain disorders

Pain ◽  
2020 ◽  
Vol 161 (12) ◽  
pp. 2852-2859 ◽  
Author(s):  
Julie Shulman ◽  
David Zurakowski ◽  
Julie Keysor ◽  
Kelsey Jervis ◽  
Navil F. Sethna
Keyword(s):  
Chronic Pain ◽  
Pain Modulation ◽  
Pediatric Chronic Pain ◽  
Endogenous Pain Modulation

scholarly journals Endogenous Pain Modulation Profiles Among Individuals With Chronic Pain: Relation to Opioid Use

2019 ◽  
Vol 20 (4) ◽  
pp. 462-471 ◽  
Author(s):  
Marc O. Martel ◽  
Kristian Petersen ◽  
Marise Cornelius ◽  
Lars Arendt-Nielsen ◽  
Robert Edwards
Keyword(s):  
Chronic Pain ◽  
Pain Modulation ◽  
Opioid Use ◽  
Endogenous Pain Modulation

scholarly journals Application of Theory in Chronic Pain Rehabilitation Research and Clinical Practice

2021 ◽  
Vol 14 (1) ◽  
pp. 106-113
Author(s):  
Zakir Uddin ◽  
Joy C. MacDermid ◽  
Fatma A. Hegazy ◽  
Tara L. Packham
Keyword(s):  
Chronic Pain ◽  
Pain Perception ◽  
Pain Modulation ◽  
Pain Mechanisms ◽  
Pain Hypersensitivity ◽  
Gate Control Theory ◽  
Controlling Mechanism ◽  
Measurement Tools ◽  
Gate Control ◽  
Chronic Pain Conditions

Introduction: Chronic pain has multiple aetiological factors and complexity. Pain theory helps us to guide and organize our thinking to deal with this complexity. The objective of this paper is to critically review the most influential theory in pain science history (the gate control theory of pain) and focus on its implications in chronic pain rehabilitation to minimize disability. Methods: In this narrative review, all the published studies that focused upon pain theory were retrieved from Ovoid Medline (from 1946 till present), EMBAS, AMED and PsycINFO data bases. Results: Chronic pain is considered a disease or dysfunction of the nervous system. In chronic pain conditions, hypersensitivity is thought to develop from changes to the physiological top-down control (inhibitory) mechanism of pain modulation according to the pain theory. Pain hypersensitivity manifestation is considered as abnormal central inhibitory control at the gate controlling mechanism. On the other hand, pain hypersensitivity is a prognostic factor in pain rehabilitation. It is clinically important to detect and manage hypersensitivity responses and their mechanisms. Conclusion: Since somatosensory perception and integration are recognized as a contributor to the pain perception under the theory, then we can use the model to direct interventions aimed at pain relief. The pain theory should be leveraged to develop and refine measurement tools with clinical utility for detecting and monitoring hypersensitivity linked to chronic pain mechanisms.

The effect of sex and gender on child and adolescent pain

2021 ◽  
pp. 127-135
Author(s):  
Katelynn E. Boerner ◽  
Edmund Keogh
Keyword(s):  
Pain Perception ◽  
Pain Modulation ◽  
Sex And Gender ◽  
Gender Role Socialization ◽  
Role Socialization ◽  
Endogenous Pain Modulation ◽  
Biopsychosocial Perspective ◽  
And Gender ◽  
Chronic Pain Conditions ◽  
Sex And Gender Differences

Male–female differences in pain perception and experience have been consistently observed in adult populations. Such differences are theorized to be related to differences in biological (e.g., sex hormones, endogenous pain modulation, and genetics), psychological (e.g., differences in coping), and social (e.g., gender role socialization) factors. In comparison to the adult literature, male–female differences in pediatric pain are less consistently observed, and differences in the prevalence rates of chronic pain conditions appear to emerge around the time of puberty. This chapter explores the evidence for sex and gender differences in pain within pediatric groups. We argue that it is critical to take a development biopsychosocial perspective to fully understand the similarities and differences between boys and girls in pain.

Effect of pain chronification and chronic pain on an endogenous pain modulation circuit in rats

Neuroscience ◽  
2015 ◽  
Vol 286 ◽  
pp. 37-44 ◽  
Author(s):  
J. Miranda ◽  
S.M.S. Lamana ◽  
E.V. Dias ◽  
M. Athie ◽  
C.A. Parada ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Pain Modulation ◽  
Endogenous Pain Modulation ◽  
Pain Chronification
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