Isolation of rare circulating tumor cells in cancer patients: technical aspects and clinical implications

2011 ◽  
Vol 11 (5) ◽  
pp. 473-485 ◽  
Author(s):  
Marco Danova ◽  
Martina Torchio ◽  
Giuliano Mazzini
Keyword(s):  
Cancer Patients ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Clinical Implications ◽  
Technical Aspects

scholarly journals Circulating Tumor Cells in Gastrointestinal Malignancies: Current Techniques and Clinical Implications

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Georg Lurje ◽  
Marc Schiesser ◽  
Andreas Claudius Hoffmann ◽  
Paul Magnus Schneider
Keyword(s):  
Colorectal Cancer ◽  
Clinical Outcome ◽  
Disease Progression ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Response To Therapy ◽  
Clinical Implications ◽  
Gastrointestinal Malignancies ◽  
Progression Of Disease

Since their introduction more than 50 years by Engell, circulating tumor cells (CTCs) have been evaluated in cancer patients and their detection has been correlated with clinical outcome, in esophageal, gastric, and colorectal cancer. With the availability of refined technologies, the identification of CTCs from peripheral blood is emerging as a useful tool for the detection of malignancy, monitoring disease progression, and measuring response to therapy. However, increasing evidence suggests a variety of factors to be responsible for disease progression. The analysis of a single CTC marker is therefore unlikely to accurately predict progression of disease with sufficient resolution and reproducibility. Here we discuss the current concept of CTCs, summarize the available techniques for their detection and characterization, and aim to provide a comprehensive update on the clinical implications of CTCs in gastrointestinal (GI) malignancies.

scholarly journals Clinical Implications of Circulating Tumor Cells of Breast Cancer Patients: Role of Epithelial–Mesenchymal Plasticity

2015 ◽  
Vol 5 ◽  
Author(s):  
Linda M. McInnes ◽  
Natalie Jacobson ◽  
Andrew Redfern ◽  
Anthony Dowling ◽  
Erik W. Thompson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Clinical Implications ◽  
Breast Cancer Patients

Clinical implications of the detection of circulating tumor cells in breast cancer patients

2012 ◽  
Vol 6 (1) ◽  
pp. 109-118 ◽  
Author(s):  
Malgorzata Banys ◽  
Andreas D Hartkopf ◽  
Natalia Krawczyk ◽  
Sven Becker ◽  
Tanja Fehm
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Clinical Implications ◽  
Breast Cancer Patients
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