Targeting the global regulator Lsr2 as a novel approach for anti-tuberculosis drug development

2012 ◽  
Vol 10 (9) ◽  
pp. 1049-1053 ◽  
Author(s):  
Jun Liu ◽  
Blair RG Gordon
Keyword(s):  
Drug Development ◽  
Global Regulator ◽  
Novel Approach

Targeting microRNAs involved in human diseases: A novel approach for modification of gene expression and drug development

2011 ◽  
Vol 82 (10) ◽  
pp. 1416-1429 ◽  
Author(s):  
Roberto Gambari ◽  
Enrica Fabbri ◽  
Monica Borgatti ◽  
Ilaria Lampronti ◽  
Alessia Finotti ◽  
...  
Keyword(s):  
Gene Expression ◽  
Drug Development ◽  
Human Diseases ◽  
Novel Approach

A novel approach to rituximab biosimilar drug development.

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. e13064-e13064 ◽  
Author(s):  
S. M. Berry ◽  
D. J. Reitsma ◽  
A. J. Combest ◽  
J. K. Bryan ◽  
J. W. Adair ◽  
...  
Keyword(s):  
Drug Development ◽  
Novel Approach

scholarly journals Phase zero trials: a novel approach in drug development process

Renal Failure ◽  
2013 ◽  
Vol 35 (7) ◽  
pp. 1044-1053
Author(s):  
Neeraj Kumar Fuloria ◽  
Shivkanya Fuloria ◽  
Syed Vakiloddin
Keyword(s):  
Drug Development ◽  
Development Process ◽  
Drug Development Process ◽  
Novel Approach

scholarly journals Research as an event: a novel approach to promote patient-focused drug development

2018 ◽  
Vol Volume 12 ◽  
pp. 673-679 ◽  
Author(s):  
Jui-Hua Tsai ◽  
Ellen Janssen ◽  
John Bridges
Keyword(s):  
Drug Development ◽  
Novel Approach ◽  
Patient Focused Drug Development

scholarly journals Sulfamethoxazole-phytochemical hybrid: A novel approach in current antibacterial drug development

2020 ◽  
Vol 101 ◽  
pp. 302
Author(s):  
S.S. Swain ◽  
S.K. Paidesetty ◽  
S. Pati ◽  
R.N. Padhy ◽  
T. Hussain
Keyword(s):  
Drug Development ◽  
Antibacterial Drug ◽  
Novel Approach

scholarly journals Nanotechnology in Preclinical and Clinical Drug Development

2018 ◽  
Vol 1 (1) ◽  
pp. 73-93 ◽  
Author(s):  
Cristian Vilos
Keyword(s):  
Drug Discovery ◽  
Drug Development ◽  
Targeted Delivery ◽  
Medical Diagnostics ◽  
Strong Impact ◽  
Drug Candidates ◽  
Clinical Drug Development ◽  
Novel Approach ◽  
Organ Specific ◽  
Clinical Drug

Nanotechnology is generating a strong impact in preclinical and clinical drug development. The diversity of current nanotechnologies offers a broad platform used to enhance the performance of drug discovery screening, to develop sensitive and specific methods used to unveil the mechanisms behind the actions of drugs, to determine the function and interaction between molecules, and to study the physiological and pathological changes of cellular components. In addition, advancements in nanobiotechnology have led to the design of new nanomaterial-based drug candidates that present a novel approach to medical diagnostics and therapeutics. The biocompatible nanoarchitecture of the marketed nanocarriers used for drug delivery has increased the solubility and effectiveness of classical drugs, and has provided the technology required for the targeted delivery of encapsulated tissue-organ specific therapeutics. Because of its effect on drug development, nanotechnology serves as the foundation for many future medical endeavors. This article provides an overview of the basics of nanobiotechnology, and discusses its applications in drug discovery, design, and delivery systems.

Pipeline Pharmacogenetics: A Novel Approach to Integrating Pharmacogenetics into Drug Development

2009 ◽  
Vol 15 (32) ◽  
pp. 3754-3763 ◽  
Author(s):  
P. Akkari ◽  
Thomas Swanson ◽  
Donna Crenshaw ◽  
Iris Grossman ◽  
Scott Sundseth ◽  
...  
Keyword(s):  
Drug Development ◽  
Novel Approach

A Novel Approach to Drug Development in Heart Failure: Towards Personalized Medicine

2014 ◽  
Vol 30 (3) ◽  
pp. 288-295 ◽  
Author(s):  
Licette C.Y. Liu ◽  
Adriaan A. Voors ◽  
Mattia A.E. Valente ◽  
Peter van der Meer
Keyword(s):  
Heart Failure ◽  
Personalized Medicine ◽  
Drug Development ◽  
Novel Approach

Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov
Keyword(s):  
Oxidative Stress ◽  
Head And Neck ◽  
Transcriptional Activation ◽  
Platinum Resistance ◽  
Mrna Levels ◽  
Strong Positive Correlation ◽  
Platinum Compounds ◽  
Copper Chelation ◽  
Novel Approach ◽  
Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

Collecting Words: A Clinical Example of a Morphology-Focused Orthographic Intervention

2020 ◽  
Vol 51 (3) ◽  
pp. 544-560 ◽  
Author(s):  
Kimberly A. Murphy ◽  
Emily A. Diehm
Keyword(s):  
Written Language ◽  
Morphological Knowledge ◽  
English Orthography ◽  
Word Level ◽  
Novel Approach ◽  
Language Pathology ◽  
The One ◽  
Critical Intervention ◽  
Reading And Spelling ◽  
Reading And Spelling Difficulties

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687

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