Glioma stem cell signaling: therapeutic opportunities and challenges

2010 ◽  
Vol 10 (5) ◽  
pp. 709-722 ◽  
Author(s):  
Jörg Dietrich ◽  
Eli L Diamond ◽  
Santosh Kesari
Keyword(s):  
Stem Cell ◽  
Cell Signaling ◽  
Glioma Stem Cell

scholarly journals Turning Cancer Stem Cells Inside Out: An Exploration of Glioma Stem Cell Signaling Pathways

2009 ◽  
Vol 284 (25) ◽  
pp. 16705-16709 ◽  
Author(s):  
Zhizhong Li ◽  
Hui Wang ◽  
Christine E. Eyler ◽  
Anita B. Hjelmeland ◽  
Jeremy N. Rich
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cancer Stem Cells ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Glioma Stem Cell ◽  
Inside Out ◽  
Cell Signaling Pathways

Molecular Switch of AhR in Repression or Activation of Stem Cell Signaling

2017 ◽  
Vol 12 (1) ◽  
pp. 28-33
Author(s):  
Yingqiu Xie ◽  
Xiuqing Zhang ◽  
Tomiris Atazhanova ◽  
Bindong Song ◽  
Qing Yang
Keyword(s):  
Stem Cell ◽  
Cell Signaling ◽  
Molecular Switch

Conserved and Differentiated Functions of CIK Receptor Kinases in Modulating Stem Cell Signaling in Arabidopsis

2021 ◽  
Author(s):  
Yafen Zhu ◽  
Chong Hu ◽  
Yanwei Cui ◽  
Li Zeng ◽  
Sunjingnan Li ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Signaling ◽  
Receptor Kinases

Abstract 416: Pluripotent Stem Cell Signaling in Pediatric Heart Failure Patients

2016 ◽  
Vol 119 (suppl_1) ◽  
Author(s):  
Kathleen C Woulfe ◽  
Phillip Tatman ◽  
Anis Karimpour-Fard ◽  
Xuan Jiang ◽  
Karin Nunley ◽  
...  
Keyword(s):  
Heart Failure ◽  
Stem Cell ◽  
Cell Signaling ◽  
Dilated Cardiomyopathy ◽  
Pediatric Patients ◽  
Disease Process ◽  
Idiopathic Dilated Cardiomyopathy ◽  
Cytokine Signaling ◽  
Common Indication ◽  
Pediatric Heart Failure

Pediatric heart failure is a heterogeneous disease process with congenital heart disease being the most common indication for heart transplantation in infants, and dilated cardiomyopathy (DCM) the most common indication in older children. Due to limitations of studying pediatric populations, there is no specific therapy for children with DCM. Importantly, the application of proven adult therapies to pediatric patients with DCM has resulted in no substantial improvement in survival over the past three decades. Therefore, there is a clear need for new approaches to better understand this disease process. In this study, we investigated global cardiac transcriptome and circulating serum proteome changes in pediatric patients with idiopathic dilated cardiomyopathy (IDC) and non-failing controls. Changes were identified in cytokine signaling, signal transduction, and transcription in pediatric IDC patients when compared to non-failing controls. Interestingly, these changes closely resemble the induction of stem cell pluripotency and signaling in resting stem cell populations. Importantly, the transcriptome changes are age-specific and were not observed in adult IDC patients. In addition, the protein profile in serum from pediatric IDC patients identified several factors related to inflammation, and treatment of cardiomyocyte-derived induced pluripotent stem cells (iPSC) with pediatric IDC serum recapitulated pathologic changes in gene expression, including expression of genes altered in the failing pediatric heart. These findings suggest that pathologic changes in cardiomyocytes may be triggered by circulating factors present in the serum resulting in pluripotent and stem cell signaling. These results provide several novel targets for future research and therapeutic intervention.

Brain-Tumor-Regenerating 3D Scaffold-Based Primary Xenograft Models for Glioma Stem Cell Targeted Drug Screening

2018 ◽  
Vol 5 (1) ◽  
pp. 139-148 ◽  
Author(s):  
Kottarapat Jeena ◽  
Cheripelil Abraham Manju ◽  
Koythatta Meethalveedu Sajesh ◽  
G Siddaramana Gowd ◽  
Thangalazhi Balakrishnan Sivanarayanan ◽  
...  
Keyword(s):  
Stem Cell ◽  
Brain Tumor ◽  
Drug Screening ◽  
Glioma Stem Cell ◽  
3D Scaffold ◽  
Xenograft Models ◽  
Targeted Drug

scholarly journals IMPS-16MESENCHYMAL TYPE GLIOMA STEM CELL EXPRESS ICOS LIGAND AND UPREGULATE ICOS+IL-10+T CELLS

2015 ◽  
Vol 17 (suppl 5) ◽  
pp. v116.3-v116
Author(s):  
Ryoichi Iwata ◽  
Tomoki Ito ◽  
Muneo Inaba ◽  
Taro Koike ◽  
Hideyuki Oshige ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
Glioma Stem Cell

scholarly journals Identification of antipsychotic drug fluspirilene as a potential anti-glioma stem cell drug

Oncotarget ◽  
2017 ◽  
Vol 8 (67) ◽  
pp. 111728-111741 ◽  
Author(s):  
Yu Dong ◽  
Takuya Furuta ◽  
Hemragul Sabit ◽  
Tomohiro Kitabayashi ◽  
Shabierjiang Jiapaer ◽  
...  
Keyword(s):  
Stem Cell ◽  
Antipsychotic Drug ◽  
Glioma Stem Cell
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