Renin–angiotensin system and hemangioblast development from human embryonic stem cells

2009 ◽  
Vol 2 (2) ◽  
pp. 137-143 ◽  
Author(s):  
Igor I Slukvin
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Renin Angiotensin

scholarly journals Therapeutic Targeting of Cancer Stem Cells in Human Glioblastoma by Manipulating the Renin-Angiotensin System

Cells ◽  
2019 ◽  
Vol 8 (11) ◽  
pp. 1364 ◽  
Author(s):  
David Tan ◽  
Imogen Roth ◽  
Agadha Wickremesekera ◽  
Paul Davis ◽  
Andrew Kaye ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Embryonic Stem ◽  
Renin Angiotensin System ◽  
Adjuvant Chemoradiotherapy ◽  
Stem Cell Markers ◽  
The Novel ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
The Central Nervous System

Patients with glioblastoma (GB), a highly aggressive brain tumor, have a median survival of 14.6 months following neurosurgical resection and adjuvant chemoradiotherapy. Quiescent GB cancer stem cells (CSCs) invariably cause local recurrence. These GB CSCs can be identified by embryonic stem cell markers, express components of the renin-angiotensin system (RAS) and are associated with circulating CSCs. Despite the presence of circulating CSCs, GB patients rarely develop distant metastasis outside the central nervous system. This paper reviews the current literature on GB growth inhibition in relation to CSCs, circulating CSCs, the RAS and the novel therapeutic approach by repurposing drugs that target the RAS to improve overall symptom-free survival and maintain quality of life.

scholarly journals Therapeutic Targeting of Cancer Stem Cells in Human Glioblastoma by Manipulating the Renin-angiotensin System

2019 ◽  
Author(s):  
David C.H. Tan ◽  
Imogen Roth ◽  
Agadha Wickremesekera ◽  
Paul F. Davis ◽  
Andrew H. Kaye ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Embryonic Stem ◽  
Renin Angiotensin System ◽  
Adjuvant Chemoradiotherapy ◽  
Stem Cell Markers ◽  
The Novel ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
The Central Nervous System

Patients with glioblastoma (GB), a highly aggressive brain tumor, have a median survival of 14.6 months following neurosurgical resection with adjuvant chemoradiotherapy. Quiescent GB cancer stem cells (CSCs) invariably cause local recurrence. These GB CSCs that can be identified by embryonic stem cell markers express components of the renin-angiotensin system and are associated with circulating CSCs. Despite the presence of circulating CSCs, GB rarely develops distant metastasis outside the central nervous system. This paper reviews the current literature on GB growth inhibition in relation to CSCs, circulating CSCs, the RAS and the novel therapeutic approach by repurposing drugs that target the renin-angiotensin system to improve overall symptom-free survival and maintain quality of life.

Ethanol alters cell cycle gene expression in human embryonic stem cells

2016 ◽  
Vol 01 (03) ◽  
pp. 201-208 ◽  
Author(s):  
Malini Krishnamoorthy ◽  
Brian Gerwe ◽  
Jamie Heimburg-Molinaro ◽  
Rachel Nash ◽  
Jagan Arumugham ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Cell Cycle Gene ◽  
Cell Cycle Gene Expression
Sign in / Sign up

Export Citation Format

Share Document