scholarly journals Chronic diarrhea caused by idiopathic bile acid malabsorption: an explanation at last

2009 ◽  
Vol 3 (5) ◽  
pp. 461-464 ◽  
Author(s):  
Alan F Hofmann
Keyword(s):  
Bile Acid ◽  
Chronic Diarrhea ◽  
Bile Acid Malabsorption

BIle acid malabsorption (BAM) in patients with functional chronic diarrhea: Response to cholestyramine

2000 ◽  
Vol 118 (4) ◽  
pp. A885 ◽  
Author(s):  
Fernando Femandez-Banares ◽  
Maria Esteve ◽  
Jorge C. Espinos ◽  
Montserrat Forne ◽  
Josep Martin-Comin ◽  
...  
Keyword(s):  
Bile Acid ◽  
Chronic Diarrhea ◽  
Bile Acid Malabsorption

scholarly journals Bile Acid Malabsorption in Chronic Diarrhea: Pathophysiology and Treatment

2013 ◽  
Vol 27 (11) ◽  
pp. 653-659 ◽  
Author(s):  
Alan Barkun ◽  
Jonathan Love ◽  
Michael Gould ◽  
Henryk Pluta ◽  
A Hillary Steinhart
Keyword(s):  
Bile Acid ◽  
High Performance ◽  
Chronic Diarrhea ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Bile Acid Malabsorption ◽  
Ileal Dysfunction ◽  
Type 3

BACKGROUND: Bile acid malabsorption (BAM) is a common but frequently under-recognized cause of chronic diarrhea, with an estimated prevalence of 4% to 5%.METHODS: The published literature for the period 1965 to 2012 was examined for articles regarding the pathophysiology and treatment of BAM to provide an overview of the management of BAM in gastroenterology practice.RESULTS: BAM is classified as type 1 (secondary to ileal dysfunction), type 2 (idiopathic) or type 3 (secondary to gastrointestinal disorders not associated with ileal dysfunction). The estimated prevalence of BAM is >90% in patients with resected Crohn disease (CD) and 11% to 52% of unresected CD patients (type 1); 33% in diarrhea-predominant irritable bowel syndrome (type 2); and is a frequent finding postcholecystectomy or postvagotomy (type 3). Investigations include BAM fecal bile acid assay, 23-seleno-25-homo-tauro-cholic acid (SeHCAT) testing and high-performance liquid chromatography of serum 7-α-OH-4-cholesten-3-one (C4), to determine the level of bile acid synthesis. A less time-consuming and expensive alternative in practice is an empirical trial of the bile acid sequestering agent cholestyramine. An estimated 70% to 96% of chronic diarrhea patients with BAM respond to short-course cholestyramine. Adverse effects include constipation, nausea, borborygmi, flatulence, bloating and abdominal pain. Other bile acid sequestering agents, such as colestipol and colesevelam, are currently being investigated for the treatment of BAM-associated diarrhea.CONCLUSIONS: BAM is a common cause of chronic diarrhea presenting in gastroenterology practice. In accordance with current guidelines, an empirical trial of a bile acid sequestering agent is warranted as part of the clinical workup to rule out BAM.

scholarly journals Bile acid malabsorption in patients with chronic diarrhea and Crohn�s disease

2018 ◽  
Vol 111 ◽  
Author(s):  
Luisa M.� Mena Bares ◽  
José M. Benítez Cantero ◽  
Eva Iglesias Flores ◽  
Beatriz Gros Alcalde ◽  
Estefanía Moreno Ortega ◽  
...  
Keyword(s):  
Bile Acid ◽  
Chronic Diarrhea ◽  
Bile Acid Malabsorption

S2061 Idiopathic Bile Acid Malabsorption Is a Common Cause of Chronic Diarrhea with Functional Characteristics

2009 ◽  
Vol 136 (5) ◽  
pp. A-322
Author(s):  
Gautam Mehta ◽  
Mathena Pavan ◽  
Samer Taslaq ◽  
Endip Dhesi ◽  
Devinder S. Bansi ◽  
...  
Keyword(s):  
Bile Acid ◽  
Chronic Diarrhea ◽  
Functional Characteristics ◽  
Common Cause ◽  
Bile Acid Malabsorption

scholarly journals Pros and Cons of the SeHCAT Test in Bile Acid Diarrhea: A More Appropriate Use of an Old Nuclear Medicine Technique

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Bernardo Fani ◽  
Lorenzo Bertani ◽  
Italia Paglianiti ◽  
Lorenzo Fantechi ◽  
Nicola De Bortoli ◽  
...  
Keyword(s):  
Nuclear Medicine ◽  
Bile Acid ◽  
Chronic Diarrhea ◽  
Response To Therapy ◽  
Bile Acid Sequestrants ◽  
Bile Acid Malabsorption ◽  
Advantages And Disadvantages ◽  
Pros And Cons ◽  
Irritable Bowel ◽  
Nuclear Medicine Technique

Bile acid malabsorption (BAM) causing chronic diarrhea may be due to organic as well as functional disorders, and some of them were included under the general label of diarrheic-type irritable bowel syndrome (IBS-D). The 75-selenium homocholic acid taurine (SeHCAT) test is a nuclear medicine investigation considered to be the gold standard for the diagnosis of bile acid malabsorption (BAM). Many studies demonstrate that it could be effective in the clinical workout of chronic diarrhea due to different conditions. The SeHCAT test provides a quantitative assessment to estimate the severity of BAM and the possible response to therapy with bile acid sequestrants (BASs). However, there is no general agreement regarding its cutoff value and the test is not widely available. The aim of this review is to discuss the advantages and disadvantages of the SeHCAT test in clinical practice.

75SeHCAT scan in bile acid malabsorption in chronic diarrhea

2017 ◽  
Vol 36 (1) ◽  
pp. 37-47 ◽  
Author(s):  
L.M. Mena Bares ◽  
E. Carmona Asenjo ◽  
M.V. García Sánchez ◽  
E. Moreno Ortega ◽  
F.R. Maza Muret ◽  
...  
Keyword(s):  
Bile Acid ◽  
Chronic Diarrhea ◽  
Bile Acid Malabsorption

Studies of the prevalence and significance of radiolabeled bile acid malabsorption in a group of patients with idiopathic chronic diarrhea

1987 ◽  
Vol 92 (1) ◽  
pp. 151-160 ◽  
Author(s):  
Lawrence R. Schiller ◽  
Reed B. Hogan ◽  
Stephen G. Morawski ◽  
Carol A. Santa Ana ◽  
M.Jon Bern ◽  
...  
Keyword(s):  
Bile Acid ◽  
Chronic Diarrhea ◽  
Bile Acid Malabsorption

Prevalence of, and predictors of, bile acid malabsorption in outpatients with chronic diarrhea

2012 ◽  
Vol 24 (11) ◽  
pp. 983-e538 ◽  
Author(s):  
D. J. Gracie ◽  
J. S. Kane ◽  
S. Mumtaz ◽  
A. F. Scarsbrook ◽  
F. U. Chowdhury ◽  
...  
Keyword(s):  
Bile Acid ◽  
Chronic Diarrhea ◽  
Bile Acid Malabsorption
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