Immunoprotective role of IDO in engraftment of allogeneic skin substitutes

2010 ◽  
Vol 5 (6) ◽  
pp. 611-616 ◽  
Author(s):  
Claudia Chavez-Munoz ◽  
Ryan Hartwell ◽  
Reza B Jalili ◽  
Aziz Ghahary
Keyword(s):  
Skin Substitutes

The role of skin substitutes in the management of chronic cutaneous wounds

2013 ◽  
Vol 21 (2) ◽  
pp. 194-210 ◽  
Author(s):  
Nicholas S. Greaves ◽  
Syed A. Iqbal ◽  
Mohamed Baguneid ◽  
Ardeshir Bayat
Keyword(s):  
Skin Substitutes ◽  
Cutaneous Wounds

The Crucial Role of Vascularization and Lymphangiogenesis in Skin Reconstruction

2018 ◽  
Vol 59 (3-4) ◽  
pp. 242-254 ◽  
Author(s):  
Florian S.  Frueh ◽  
Nadia Sanchez-Macedo ◽  
Maurizio Calcagni ◽  
Pietro Giovanoli ◽  
Nicole Lindenblatt
Keyword(s):  
Clinical Practice ◽  
Skin Grafting ◽  
Lymphatic Drainage ◽  
Skin Grafts ◽  
Skin Substitutes ◽  
Microvascular Network ◽  
Skin Defects ◽  
Dermal Substitutes ◽  
Skin Reconstruction

Background: The treatment of extensive skin defects and bradytrophic wounds remains a challenge in clinical practice. Despite emerging tissue engineering approaches, skin grafts and dermal substitutes are still the routine procedure for the majority of skin defects. Here, we review the role of vascularization and lymphangiogenesis for skin grafting and dermal substitutes from the clinician’s perspective. Summary: Graft revascularization is a dynamic combination of inosculation, angiogenesis, and vasculogenesis. The majority of a graft’s microvasculature regresses and is replaced by ingrowing microvessels from the wound bed, finally resulting in a chimeric microvascular network. After inosculation within 48–72 h, the graft is re-oxygenated. In contrast to skin grafts, the vascularization of dermal substitutes is slow and dependent on the ingrowth of vessel-forming angiogenic cells. Preclinical angiogenic strategies with adipose tissue-derived isolates are appealing for the treatment of difficult wounds and may markedly accelerate skin reconstruction in the future. However, their translation from bench to bedside is still restricted by major regulatory restrictions. Finally, the lymphatic system contributes to edema reduction and the removal of local wound debris. Therapeutic lymphangiogenesis is an emerging field of research in skin reconstruction. Key Messages: For the successful engraftment of skin grafts and dermal substitutes, the rapid formation of a microvascular network is of pivotal importance. Hence, to understand the biological processes behind revascularization of skin substitutes and to implement this knowledge into clinical practice is a prerequisite when treating skin defects. Furthermore, a functional lymphatic drainage crucially contributes to the engraftment of skin substitutes.

scholarly journals The Importance of Mimicking Dermal-Epidermal Junction for Skin Tissue Engineering: A Review

2021 ◽  
Vol 8 (11) ◽  
pp. 148
Author(s):  
Mina Aleemardani ◽  
Michael Zivojin Trikić ◽  
Nicola Helen Green ◽  
Frederik Claeyssens
Keyword(s):  
Tissue Engineering ◽  
Cell Function ◽  
Multiple Roles ◽  
Primary Role ◽  
Skin Substitutes ◽  
Anatomical Structures ◽  
And Function ◽  
Bioengineered Skin ◽  
Physical Boundary

There is a distinct boundary between the dermis and epidermis in the human skin called the basement membrane, a dense collagen network that creates undulations of the dermal–epidermal junction (DEJ). The DEJ plays multiple roles in skin homeostasis and function, namely, enhancing the adhesion and physical interlock of the layers, creating niches for epidermal stem cells, regulating the cellular microenvironment, and providing a physical boundary layer between fibroblasts and keratinocytes. However, the primary role of the DEJ has been determined as skin integrity; there are still aspects of it that are poorly investigated. Tissue engineering (TE) has evolved promising skin regeneration strategies and already developed TE scaffolds for clinical use. However, the currently available skin TE equivalents neglect to replicate the DEJ anatomical structures. The emergent ability to produce increasingly complex scaffolds for skin TE will enable the development of closer physical and physiological mimics to natural skin; it also allows researchers to study the DEJ effect on cell function. Few studies have created patterned substrates that could mimic the human DEJ to explore their significance. Here, we first review the DEJ roles and then critically discuss the TE strategies to create the DEJ undulating structure and their effects. New approaches in this field could be instrumental for improving bioengineered skin substitutes, creating 3D engineered skin, identifying pathological mechanisms, and producing and screening drugs.

The Role of Fibroblasts in Skin Substitutes

2005 ◽  
Vol 13 (1) ◽  
pp. A22-A22
Author(s):  
E Middelkoop ◽  
A Van Den Bogaerdt ◽  
M Ulrich
Keyword(s):  
Skin Substitutes

The Role of Biological Skin Substitutes in Stevens–Johnson Syndrome

2018 ◽  
Vol 38 (3) ◽  
pp. 121-127 ◽  
Author(s):  
André Oliveira Paggiaro ◽  
Markinokoff Lima e Silva Filho ◽  
Viviane Fernandes de Carvalho ◽  
César Isaac ◽  
Rolf Gemperli
Keyword(s):  
Stevens Johnson Syndrome ◽  
Skin Substitutes ◽  
Johnson Syndrome

scholarly journals Regeneration of Dermis: Scarring and Cells Involved

Cells ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 607 ◽  
Author(s):  
Alexandra L. Rippa ◽  
Ekaterina P. Kalabusheva ◽  
Ekaterina A. Vorotelyak
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Hair Follicle ◽  
Scar Formation ◽  
Population Characteristics ◽  
Matrix Composition ◽  
Skin Substitutes ◽  
Skin Repair ◽  
Dermal Cell

There are many studies on certain skin cell specifications and their contribution to wound healing. In this review, we provide an overview of dermal cell heterogeneity and their participation in skin repair, scar formation, and in the composition of skin substitutes. The papillary, reticular, and hair follicle associated fibroblasts differ not only topographically, but also functionally. Human skin has a number of particular characteristics that are different from murine skin. This should be taken into account in experimental procedures. Dermal cells react differently to skin wounding, remodel the extracellular matrix in their own manner, and convert to myofibroblasts to different extents. Recent studies indicate a special role of papillary fibroblasts in the favorable outcome of wound healing and epithelial-mesenchyme interactions. Neofolliculogenesis can substantially reduce scarring. The role of hair follicle mesenchyme cells in skin repair and possible therapeutic applications is discussed. Participation of dermal cell types in wound healing is described, with the addition of possible mechanisms underlying different outcomes in embryonic and adult tissues in the context of cell population characteristics and extracellular matrix composition and properties. Dermal white adipose tissue involvement in wound healing is also overviewed. Characteristics of myofibroblasts and their activity in scar formation is extensively discussed. Cellular mechanisms of scarring and possible ways for its prevention are highlighted. Data on keloid cells are provided with emphasis on their specific characteristics. We also discuss the contribution of tissue tension to the scar formation as well as the criteria and effectiveness of skin substitutes in skin reconstruction. Special attention is given to the properties of skin substitutes in terms of cell composition and the ability to prevent scarring.

scholarly journals Bioengineered Skin Substitutes: The Role of Extracellular Matrix and Vascularization in the Healing of Deep Wounds

2019 ◽  
Vol 8 (12) ◽  
pp. 2083 ◽  
Author(s):  
Francesco Urciuolo ◽  
Costantino Casale ◽  
Giorgia Imparato ◽  
Paolo A. Netti
Keyword(s):  
Extracellular Matrix ◽  
Hair Follicles ◽  
Sweat Glands ◽  
Skin Wounds ◽  
Skin Substitutes ◽  
Skin Tissue Engineering ◽  
Skin Cells ◽  
Bioengineered Skin ◽  
A Current

The formation of severe scars still represents the result of the closure process of extended and deep skin wounds. To address this issue, different bioengineered skin substitutes have been developed but a general consensus regarding their effectiveness has not been achieved yet. It will be shown that bioengineered skin substitutes, although representing a valid alternative to autografting, induce skin cells in repairing the wound rather than guiding a regeneration process. Repaired skin differs from regenerated skin, showing high contracture, loss of sensitivity, impaired pigmentation and absence of cutaneous adnexa (i.e., hair follicles and sweat glands). This leads to significant mobility and aesthetic concerns, making the development of more effective bioengineered skin models a current need. The objective of this review is to determine the limitations of either commercially available or investigational bioengineered skin substitutes and how advanced skin tissue engineering strategies can be improved in order to completely restore skin functions after severe wounds.

scholarly journals WOUND HEALING CONCEPTS: CONTEMPORARY PRACTICES AND FUTURE PERSPECTIVES

2020 ◽  
pp. 7-15
Author(s):  
SHARON C. FURTADO ◽  
BHARATH SRINIVASAN ◽  
SINDHU ABRAHAM
Keyword(s):  
Wound Healing ◽  
Wound Care ◽  
Wound Dressings ◽  
Smart Devices ◽  
Skin Substitutes ◽  
Negative Pressure Therapy ◽  
Pressure Therapy ◽  
The Past ◽  
Systemic Factors

The advancements in the development of wound dressings have seen tremendous growth in the past few decades. Wound healing approach has majorly shifted from dry healing to moist healing. There has been a significant advancement in our understanding of the underlying physiology involved in wound healing and the associated systemic factors having a direct or indirect influence on the healing. This has resulted in the development of wound dressings designed to treat specific types of wounds. The present review discusses the physiology of wound healing, followed by different factors that contribute to healing. The advancements in wound dressings with their merits and limitations, newer approaches in wound care i.e., hyperbaric oxygen, negative pressure therapy, skin substitutes and role of growth factors in wound healing, have been highlighted. In addition, more recent approaches for effective wound care like smart devices with sensing, reporting and responding functions are discussed.

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