Predicting drug–drug interactions: application of physiologically based pharmacokinetic models under a systems biology approach

Karen Rowland Yeo; Masoud Jamei; Amin Rostami-Hodjegan

doi:10.1586/ecp.13.4

Predicting drug–drug interactions: application of physiologically based pharmacokinetic models under a systems biology approach

Expert Review of Clinical Pharmacology ◽

10.1586/ecp.13.4 ◽

2013 ◽

Vol 6 (2) ◽

pp. 143-157 ◽

Cited By ~ 34

Author(s):

Karen Rowland Yeo ◽

Masoud Jamei ◽

Amin Rostami-Hodjegan

Keyword(s):

Systems Biology ◽

Drug Interactions ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Critical Impact of Drug-Drug Interactions via Intestinal CYP3A in the Risk Assessment of Weak Perpetrators Using Physiologically Based Pharmacokinetic Models

Drug Metabolism and Disposition ◽

10.1124/dmd.119.089599 ◽

2020 ◽

Vol 48 (4) ◽

pp. 288-296 ◽

Cited By ~ 2

Author(s):

Makiko Yamada ◽

Shin-ichi Inoue ◽

Daisuke Sugiyama ◽

Yumi Nishiya ◽

Tomoko Ishizuka ◽

...

Keyword(s):

Risk Assessment ◽

Drug Interactions ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Quantitative Prediction of Drug-Drug Interactions Involving Inhibitory Metabolites by Physiologically Based Pharmacokinetic Models: Is it Worth It?

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12164 ◽

2017 ◽

Vol 6 (4) ◽

pp. 226-226 ◽

Cited By ~ 1

Author(s):

M Tod ◽

S Goutelle ◽

L Bourguignon ◽

N Bleyzac

Keyword(s):

Drug Interactions ◽

Quantitative Prediction ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically‐Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug–Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.1693 ◽

2019 ◽

Vol 107 (5) ◽

pp. 1082-1115 ◽

Cited By ~ 10

Author(s):

Kunal S. Taskar ◽

Venkatesh Pilla Reddy ◽

Howard Burt ◽

Maria M. Posada ◽

Manthena Varma ◽

...

Keyword(s):

Drug Interactions ◽

Case Studies ◽

Membrane Transporter ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Application of permeability‐limited physiologically-based pharmacokinetic models: Part II-prediction of p‐glycoprotein mediated drug–drug interactions with digoxin

Journal of Pharmaceutical Sciences ◽

10.1002/jps.23607 ◽

2013 ◽

Vol 102 (9) ◽

pp. 3161-3173 ◽

Cited By ~ 33

Author(s):

Sibylle Neuhoff ◽

Karen Rowland Yeo ◽

Zoe Barter ◽

Masoud Jamei ◽

David B. Turner ◽

...

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

P Glycoprotein ◽

Physiologically Based

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Quantitative Analyses of the Influence of Parameters Governing Rate-Determining Process of Hepatic Elimination of Drugs on the Magnitudes of Drug-Drug Interactions via Hepatic OATPs and CYP3A Using Physiologically Based Pharmacokinetic Models

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2017.05.001 ◽

2017 ◽

Vol 106 (9) ◽

pp. 2739-2750 ◽

Cited By ~ 9

Author(s):

Takashi Yoshikado ◽

Kazuya Maeda ◽

Hiroyuki Kusuhara ◽

Ken-ichi Furihata ◽

Yuichi Sugiyama

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Models ◽

Hepatic Elimination ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Quantitative Analyses

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Prediction of drug-drug interactions using physiologically-based pharmacokinetic models of CYP450 modulators included in Simcyp software

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2107 ◽

2017 ◽

Vol 39 (1) ◽

pp. 3-17 ◽

Cited By ~ 15

Author(s):

Niloufar Marsousi ◽

Jules A. Desmeules ◽

Serge Rudaz ◽

Youssef Daali

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Predictive Performance of Physiologically-Based Pharmacokinetic Models in Predicting Drug–Drug Interactions Involving Enzyme Modulation

Clinical Pharmacokinetics ◽

10.1007/s40262-018-0635-8 ◽

2018 ◽

Vol 57 (10) ◽

pp. 1337-1346 ◽

Cited By ~ 10

Author(s):

Chia-Hsiang Hsueh ◽

Vicky Hsu ◽

Yuzhuo Pan ◽

Ping Zhao

Keyword(s):

Drug Interactions ◽

Predictive Performance ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Enzyme Modulation ◽

Physiologically Based

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Response to “Quantitative Prediction of Drug-Drug Interactions Involving Inhibitory Metabolites by Physiologically Based Pharmacokinetic Models: Is It Worth?”

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12183 ◽

2017 ◽

Vol 6 (4) ◽

pp. 227-227

Author(s):

IE Templeton ◽

Y Chen ◽

J Mao ◽

J Lin ◽

H Yu ◽

...

Keyword(s):

Drug Interactions ◽

Quantitative Prediction ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Using Physiologically-Based Pharmacokinetic Models to Incorporate Chemical and Non-Chemical Stressors into Cumulative Risk Assessment: A Case Study of Pesticide Exposures

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph9051971 ◽

2012 ◽

Vol 9 (5) ◽

pp. 1971-1983 ◽

Cited By ~ 7

Author(s):

Susan C. Wason ◽

Thomas J. Smith ◽

Melissa J. Perry ◽

Jonathan I. Levy

Keyword(s):

Risk Assessment ◽

Cumulative Risk ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Pesticide Exposures ◽

Physiologically Based

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Response to “The Link Between Pharmacodynamics and Physiologically Based Pharmacokinetic Models”

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.2012.216 ◽

2012 ◽

Vol 93 (2) ◽

pp. 152-152 ◽

Cited By ~ 5

Author(s):

A Rostami-Hodjegan

Keyword(s):

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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