Could combating vitamin D deficiency reduce the incidence of autoimmune disease?

2011 ◽  
Vol 7 (3) ◽  
pp. 255-257 ◽  
Author(s):  
Brent W Kinder ◽  
Jared T Hagaman
Keyword(s):  
Vitamin D ◽  
Autoimmune Disease ◽  
Vitamin D Deficiency

scholarly journals Vitamin D Deficiency in Rheumatoid Arthritis and Vitamin D Levels that vary with Rheumatoid Arthritis Severity: An Indian Study

2017 ◽  
Vol 51 (4) ◽  
pp. 162-165 ◽  
Author(s):  
Muzamil Latief ◽  
Farhat Abbas ◽  
Amandeep Minhas ◽  
Waseem Dar ◽  
Manzoor Parry ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Vitamin D ◽  
Autoimmune Disease ◽  
Disease Activity ◽  
Vitamin D Deficiency ◽  
Arthritis Severity ◽  
Indian Study ◽  
Das 28 ◽  
Rheumatoid Arthritis Severity ◽  
Vitamin D Levels

ABSTRACT Introduction Rheumatoid arthritis (RA) is an autoimmune disease characterized by periods of remission and flares of symmetrical joint inflammation slowly progressing to joint and cartilage destruction leading to deformities. Evidence is accumulating suggesting vitamin D deficiency and its correlation in autoimmune diseases including RA. Aims of study (1) Estimation of vitamin D levels in RA patients. (2) Correlation of vitamin D levels with severity of the disease. Materials and methods A study population of 50 included 25 cases and 25 controls. Both males and females of 30 to 40 years of age were taken for this study. Patients of RA having any other autoimmune disease were excluded. Twenty-five healthy adults, whose ages were between 30 and 40 years, both male and female, free from any systemic illness were taken as controls. Routine systematic examination and detailed joint examination were done. Disease activity was measured in patients of RA according to Disease Activity Score (DAS-28). Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), and anticyclic citrullinated peptide (CCP) among other routine blood investigations were done. Results In cases, the mean vitamin D level was 18.41 ng/mL with standard deviation (SD) of 7.10, while controls had mean level as 22.32 ng/mL with SD as 4.80. The difference between the two was recorded as statistically significant, i.e., p-value <0.05. While 4 (16.0%) patients had low severity, 15 (60.0%) had moderate severity, and 6 (24.0%) patients had high severity of disease as per DAS-28. Patients whose RA disease activity was high had lower vitamin D levels. Conclusion It is thus concluded that in RA patients the serum vitamin D levels are significantly lower than in healthy control, and vitamin D deficiency may be one of the causes contributing to worsening of RA. How to cite this article Latief M, Abbas F, Minhas A, Dar W, Parry M, Gupta PD. Vitamin D Deficiency in Rheumatoid Arthritis and Vitamin D Levels that vary with Rheumatoid Arthritis Severity: An Indian Study. J Postgrad Med Edu Res 2017;51(4):162-165.

scholarly journals False Positive ANA Testing In The Setting Of Hypovitaminosis D

2020 ◽  
Vol 7 (3) ◽  
pp. 1-5
Author(s):  
Philip V Peplow ◽  
Keyword(s):  
Vitamin D ◽  
Autoimmune Disease ◽  
Autoimmune Diseases ◽  
Vitamin D Deficiency ◽  
Lupus Erythematosus ◽  
False Positive ◽  
Hypovitaminosis D ◽  
Vitamin D Insufficiency ◽  
Vitamin Supplementation ◽  
Systemic Autoimmune Diseases

Vitamin D deficiency has been associated with autoimmune diseases, which include systemic lupus erythematosus, and may affect the outcome and activity of these diseases that result from aberrant activation of the immune system. Patients with the systemic autoimmune diseases may have a positive blood test for Antinuclear Antibodies (ANA). The ANA test is very sensitive for the diagnosis of autoimmune diseases but results in many false positives. It has been reported that up to 15% of completely healthy individuals have a positive ANA test without an autoimmune disease and that ANAs are measurable in approximately 25% of the population. Only about 10-13% of persons with a positive ANA test are found to have lupus. Vitamin D insufficiency/deficiency is prevalent in patients with autoimmune disease and vitamin supplementation has a therapeutic effect on disease severity and progression. Though there are many studies supporting the clinical picture that lupus patients are more prone to vitamin D deficiency, there are only a few articles that have considered the possibility that hypovitaminosis D is associated with false positive ANA testing. A case of an anemic patient who was initially evaluated and managed as a case of lupus is presented.

Vitamin D Deficiency

2011 ◽  
Vol 44 (14) ◽  
pp. 22
Author(s):  
WILLIAM E. GOLDEN ◽  
ROBERT H. HOPKINS
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency

Abstract #1236: The Blood Turnover Markers and Parathormon Levels in Menopausal Women with Vitamin D Deficiency

2015 ◽  
Vol 21 ◽  
pp. 293-294
Author(s):  
Mara Carsote ◽  
Cristina Capatina ◽  
Alexandra Mihai ◽  
Andreea Geleriu ◽  
Rodica Petris ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Menopausal Women ◽  
Turnover Markers

Vitamin D3 supplementation improves glycemic control in type 2 diabetic patients: Results from an Italian clinical trial

2020 ◽  
pp. 1-10
Author(s):  
Giuseppe Derosa ◽  
Angela D’Angelo ◽  
Chiara Martinotti ◽  
Maria Chiara Valentino ◽  
Sergio Di Matteo ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Metabolic Control ◽  
Vitamin D3 ◽  
Therapy Group ◽  
Hypoglycemic Agents ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Abstract. Background: to evaluate the effects of Vitamin D3 on glyco-metabolic control in type 2 diabetic patients with Vitamin D deficiency. Methods: one hundred and seventeen patients were randomized to placebo and 122 patients to Vitamin D3. We evaluated anthropometric parameters, glyco-metabolic control, and parathormone (PTH) value at baseline, after 3, and 6 months. Results: a significant reduction of fasting, and post-prandial glucose was recorded in Vitamin D3 group after 6 months. A significant HbA1c decrease was observed in Vitamin D3 (from 7.6% or 60 mmol/mol to 7.1% or 54 mmol) at 6 months compared to baseline, and to placebo (p < 0.05 for both). At the end of the study period, we noticed a change in the amount in doses of oral or subcutaneous hypoglycemic agents and insulin, respectively. The use of metformin, acarbose, and pioglitazone was significantly lower (p = 0.037, p = 0.048, and p = 0.042, respectively) than at the beginning of the study in the Vitamin D3 therapy group. The units of Lispro, Aspart, and Glargine insulin were lower in the Vitamin D3 group at the end of the study (p = 0.031, p = 0.037, and p = 0.035, respectively) than in the placebo group. Conclusions: in type 2 diabetic patients with Vitamin D deficiency, the restoration of value in the Vitamin D standard has led not only to an improvement in the glyco-metabolic compensation, but also to a reduced posology of some oral hypoglycemic agents and some types of insulin used.

Sign in / Sign up

Export Citation Format

Share Document