scholarly journals Coronary artery aneurism – is a stent enough?

2020 ◽  
Vol 15 (3-4) ◽  
pp. 45-45
Author(s):  
Sandra Makarović ◽  
Marin Vučković ◽  
Zorin Makarović ◽  
Damir Kirner
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Aneurism

scholarly journals Left main coronary artery aneurism in an adult

2018 ◽  
Vol 55 (1) ◽  
pp. 25
Author(s):  
Lakshman Bandara ◽  
Thangaraja Kogulan ◽  
Arulkumar Jegavanthan ◽  
Gamini Weerakoon
Keyword(s):  
Coronary Artery ◽  
Left Main Coronary Artery ◽  
Left Main ◽  
Coronary Artery Aneurism

scholarly journals A Giant Coronary Artery Aneurysm with Coronary Arteriovenous Fistula in Asymptomatic Elderly Patient

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Caterina Milici ◽  
Daniella Bovelli ◽  
Valentino Borghetti ◽  
Georgette Khoury ◽  
Marco Bazzucchi ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Arteriovenous Fistula ◽  
Chest Trauma ◽  
Coronary Artery Aneurysm ◽  
Previous History ◽  
Artery Aneurysm ◽  
Coronary Arteriovenous Fistula ◽  
Giant Coronary Artery Aneurysm ◽  
History Of ◽  
Coronary Artery Aneurism

Coronary Arteriovenous Fistula (CAF) is a rare defect that occurs in 0.1-0.2% of patients undergoing coronary angiography; Coronary Artery Aneurism (CAA) also occurs in approximately 15–19% of patients with CAF. It is usually congenital, but in rare occasions it occurs after chest trauma, cardiac surgery, or coronary interventions. The case described is that of a 72-year-old woman, without previous history of cardiovascular disease, who presented a huge cardiac mass. A multimodal approach was necessary to diagnose a giant CAA with CAF responsible for compression and displacement of cardiac structures. Due to likely congenitally origin of the lesion and the absence of symptoms correlated to the CAA and to the CAF we decided to avoid invasive interventions and to treat the patient with medical therapy.

Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease

2019 ◽  
Vol 133 (22) ◽  
pp. 2283-2299
Author(s):  
Apabrita Ayan Das ◽  
Devasmita Chakravarty ◽  
Debmalya Bhunia ◽  
Surajit Ghosh ◽  
Prakash C. Mandal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Chronic Inflammation ◽  
Ex Vivo ◽  
Human Subjects ◽  
Critical Role ◽  
Atherosclerotic Cardiovascular Disease ◽  
Tnf Α ◽  
Artery Disease

Abstract The role of inflammation in all phases of atherosclerotic process is well established and soluble TREM-like transcript 1 (sTLT1) is reported to be associated with chronic inflammation. Yet, no information is available about the involvement of sTLT1 in atherosclerotic cardiovascular disease. Present study was undertaken to determine the pathophysiological significance of sTLT1 in atherosclerosis by employing an observational study on human subjects (n=117) followed by experiments in human macrophages and atherosclerotic apolipoprotein E (apoE)−/− mice. Plasma level of sTLT1 was found to be significantly (P<0.05) higher in clinical (2342 ± 184 pg/ml) and subclinical cases (1773 ± 118 pg/ml) than healthy controls (461 ± 57 pg/ml). Moreover, statistical analyses further indicated that sTLT1 was not only associated with common risk factors for Coronary Artery Disease (CAD) in both clinical and subclinical groups but also strongly correlated with disease severity. Ex vivo studies on macrophages showed that sTLT1 interacts with Fcɣ receptor I (FcɣRI) to activate spleen tyrosine kinase (SYK)-mediated downstream MAP kinase signalling cascade to activate nuclear factor-κ B (NF-kB). Activation of NF-kB induces secretion of tumour necrosis factor-α (TNF-α) from macrophage cells that plays pivotal role in governing the persistence of chronic inflammation. Atherosclerotic apoE−/− mice also showed high levels of sTLT1 and TNF-α in nearly occluded aortic stage indicating the contribution of sTLT1 in inflammation. Our results clearly demonstrate that sTLT1 is clinically related to the risk factors of CAD. We also showed that binding of sTLT1 with macrophage membrane receptor, FcɣR1 initiates inflammatory signals in macrophages suggesting its critical role in thrombus development and atherosclerosis.

Sign in / Sign up

Export Citation Format

Share Document