scholarly journals A saphenous vein graft aneurysm nineteen years after aortocoronary bypass graft surgery: from diagnosis to reoperation.

2016 ◽  
Vol 11 (3-4) ◽  
pp. 114-114
Author(s):  
Zoran Miovski ◽  
Miroslav Krpan ◽  
Bojan Biocina ◽  
Josko Bulum
Keyword(s):  
Saphenous Vein ◽  
Vein Graft ◽  
Saphenous Vein Graft ◽  
Bypass Graft ◽  
Aortocoronary Bypass ◽  
Aortocoronary Bypass Graft

Abstract 15922: Role of Polo-Like Kinase-1 in Intimal Hyperplasia in Saphenous Vein Graft: Potential Implication in Vein-Graft Disease

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Swastika Sur ◽  
Songcang Chen ◽  
Jeffrey T Sugimoto ◽  
Devendra K Agrawal
Keyword(s):  
Coronary Artery ◽  
Saphenous Vein ◽  
Intimal Hyperplasia ◽  
Vein Graft ◽  
Saphenous Vein Graft ◽  
Bypass Graft ◽  
Fold Increase ◽  
Potential Implication ◽  
Vein Graft Disease ◽  
Graft Disease

Coronary revascularization by coronary artery bypass grafting (CABG) is the choice of procedure in patients with multi-vessel or left main coronary artery disease. Concerns have been raised on the long term result of CABG using saphenous vein graft (SVG) as its patency significantly declines following surgery, compared to internal mammary artery (IMA), which is almost immune to restenosis. Proliferation of smooth muscle cells (SMCs) is the key event in the pathogenesis of intimal hyperplasia leading to SVG failure. PDGF-BB is a major growth factor released at the site of pulsatile stretch- and shear stress-induced graft injury. Here, we examined, for the first time, the expression of PLK1 and its phosphorylation/activation in isolated human bypass graft conduits. Human SV and IMA vessels were freshly collected, SMCs isolated and cultured up to 5th passage. In cultured SMCs, effect of PDGF-BB was examined on total and phosphorylated PLK1 (pPLK1) by Western blot analysis. Cell proliferation was measured using thymidine incorporation, MTT method and cell count. We found significantly higher expression of pPLK1 and total PLK1 in PDGF-stimulated SV SMCs than IMA. SV SMCs had 5-fold increase in the density of pPLK1 and had 2-fold increase in the density of total PLK1. While in the IMA SMCs, increase in pPLK1 was significantly lower than in SV SMCs. Also, this increase was not sustained. These data suggest a greater and sustained sensitivity of SV SMCs to PDGF-BB induced PLK1 activity than that of IMA. A PLK1 blocker inhibited PDGF-induced proliferation in both IMA and SV SMCs. These data demonstrate differential activity of PDGF-induced PLK1 activation, which was greater in SV SMCs than in IMA. This could explain the development of intimal hyperplasia in SV conduits than the IMA following CABG. Thus, inhibition of PLK1 could be a target in developing better therapeutic approach to prevent vein-graft disease.

Revascularization using the saphenous vein as a composite graft

2021 ◽  
pp. 255-258
Author(s):  
Ki-Bong Kim
Keyword(s):  
Saphenous Vein ◽  
Bypass Graft ◽  
Composite Graft ◽  
Ascending Aorta ◽  
Neurological Injury ◽  
Aortocoronary Bypass ◽  
Aortocoronary Bypass Graft ◽  
Almost All

The saphenous vein conduit has been used as an aortocoronary bypass graft in almost all previous studies, and its use as a composite graft was reserved for patients with diffusely atherosclerotic or calcified ascending aorta to minimize ascending aorta manipulation and to reduce the risk of neurological injury.

Predictors of early saphenous vein aortocoronary bypass graft occlusion

1993 ◽  
Vol 56 (5) ◽  
pp. 1101-1106 ◽  
Author(s):  
Marco A. Paz ◽  
José Lupon ◽  
Xavier Bosch ◽  
JoséL. Pomar ◽  
Ginés Sanz
Keyword(s):  
Saphenous Vein ◽  
Bypass Graft ◽  
Graft Occlusion ◽  
Aortocoronary Bypass ◽  
Aortocoronary Bypass Graft

scholarly journals Saphenous Vein Graft Aneurysm after Drug-Eluting Stent Implantation: Treatment by Covered Stent

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Kyriacos Papadopoulos ◽  
Panayiotis Avraamides
Keyword(s):  
Saphenous Vein ◽  
Stent Implantation ◽  
Vein Graft ◽  
Saphenous Vein Graft ◽  
Bypass Graft ◽  
Clinical Manifestations ◽  
Covered Stent ◽  
Percutaneous Intervention ◽  
Covered Stents ◽  
Surgical Technical

Saphenous vein graft aneurysms (SVGAs) occur as a rare complication of coronary artery bypass graft but increases the risk of morbidity and mortality. Atherosclerosis is considered to be the most common cause of saphenous vein graft aneurysms. Other etiologies include infections, varicosities of vein grafts, and surgical technical issues. These aneurysms usually present as an incidental finding of a mediastinal or cardiac mass on chest radiograph. Symptomatic aneurysms may present with a wide variety of clinical manifestations such as chest pain/angina, shortness of breath, and myocardial infarction. Treatment options of SVG aneurysms include surgery, percutaneous intervention (including vascular plugs, covered stents, and embolization coils), and conservative management. Herein, we describe a case of a saphenous vein graft aneurysm that developed after percutaneous intervention, which has never been described, to our knowledge, in the previous literature. The aneurysm was treated with polytetrafluoroethylene covered stent implantation.

Aortocoronary bypass with saphenous vein graft

JAMA ◽  
1996 ◽  
Vol 276 (18) ◽  
pp. 1521-1521
Author(s):  
V. L. Willman
Keyword(s):  
Saphenous Vein ◽  
Vein Graft ◽  
Saphenous Vein Graft ◽  
Aortocoronary Bypass
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