scholarly journals Role of nitric oxide and NADPH oxidase-derived superoxide in regulating coronary blood flow and metabolism in cardio-metabolic diseases

2014 ◽  
Vol 9 (5-6) ◽  
pp. 255-255
Author(s):  
Akos Koller
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Nadph Oxidase ◽  
Coronary Blood Flow ◽  
Metabolic Diseases

scholarly journals Role of nitric oxide in regulation of coronary blood flow during myocardial ischemia in dogs

1996 ◽  
Vol 27 (7) ◽  
pp. 1804-1812 ◽  
Author(s):  
Masafumi Kitakaze ◽  
Koichi Node ◽  
Tetsuo Minamino ◽  
Hiroaki Kosaka ◽  
Yoshiro Shinozaki ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Myocardial Ischemia ◽  
Coronary Blood Flow

scholarly journals 106 Role of neuronal vs endothelial nitric oxide synthase in the coronary blood flow response to pacing

Heart ◽  
2012 ◽  
Vol 98 (Suppl 1) ◽  
pp. A60.2-A61
Author(s):  
H Shabeeh ◽  
N Melikian ◽  
R Dworakowski ◽  
B Casadei ◽  
P Chowienczyk ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Nitric Oxide Synthase ◽  
Coronary Blood Flow ◽  
Endothelial Nitric Oxide Synthase ◽  
Blood Flow Response ◽  
Flow Response ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

scholarly journals Role of Nitric Oxide and Adenosine in Control of Coronary Blood Flow in Exercising Dogs

Circulation ◽  
2000 ◽  
Vol 101 (25) ◽  
pp. 2942-2948 ◽  
Author(s):  
Johnathan D. Tune ◽  
Keith Neu Richmond ◽  
Mark W. Gorman ◽  
Eric O. Feigl
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Coronary Blood Flow

scholarly journals Differential role of endothelial versus neuronal nitric oxide synthase in the regulation of coronary blood flow during pacing-induced increases in cardiac workload

2013 ◽  
Vol 304 (9) ◽  
pp. H1277-H1282 ◽  
Author(s):  
Husain Shabeeh ◽  
Narbeh Melikian ◽  
Rafal Dworakowski ◽  
Barbara Casadei ◽  
Phil Chowienczyk ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Nitric Oxide Synthase ◽  
Coronary Blood Flow ◽  
Human Study ◽  
Right Atrial ◽  
Atrial Pacing ◽  
Relative Contribution ◽  
Oxide Synthase

Endothelial nitric oxide synthase (eNOS) was assumed to be the only source of nitric oxide (NO) involved in the regulation of human coronary blood flow (CBF). However, our recent first-in-human study using the neuronal NOS (nNOS)-selective inhibitor S-methyl-L-thiocitrulline (SMTC) showed that nNOS-derived NO also plays a role. In this study, we investigated the relative contribution of nNOS and eNOS to the CBF response to a pacing-induced increase in cardiac workload. Incremental right atrial pacing was undertaken in patients with angiographically normal coronary arteries during intracoronary infusion of saline vehicle and then either SMTC or NG-monomethyl-l-arginine (l-NMMA; which inhibits both eNOS and nNOS). Intracoronary SMTC (0.625 μmol/min) and l-NMMA (25 μmol/min) reduced basal CBF to a similar extent (−19.2 ± 3.2% and 25.0 ± 2.7%, respectively; n = 10 per group). Pacing-induced increases in CBF were significantly blunted by l-NMMA (maximum CBF: 83.5 ± 14.2 ml/min during saline vs. 61.6 ± 9.5 ml/min during l-NMMA; P < 0.01). By contrast, intracoronary SMTC had no effect on the maximum CBF during pacing (98.5 ± 12.9 ml/min during saline vs. 102.1 ± 16.6 ml/min during SMTC; P = not significant). l-NMMA also blunted the pacing-induced increase in coronary artery diameter ( P < 0.001 vs. saline), whereas SMTC had no effect. Our results confirm a role of nNOS in the regulation of basal CBF in humans but show that coronary vasodilation in response to a pacing-induced increase in cardiac workload is exclusively mediated by eNOS-derived NO.

scholarly journals Role of Nitric Oxide in Regulation of Coronary Blood Flow in Response to Increased Metabolic Demand in Dogs With Pacing-Induced Heart Failure

2001 ◽  
Vol 65 (9) ◽  
pp. 827-833 ◽  
Author(s):  
Hideo Tada ◽  
Kensuke Egashira ◽  
Mitsutaka Yamamoto ◽  
Makoto Usui ◽  
Yukinori Arai ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Heart Failure ◽  
Blood Flow ◽  
Coronary Blood Flow ◽  
Metabolic Demand

The role of endogenous nitric oxide in the response of coronary blood flow to tachycardia

1996 ◽  
Vol 7 (2) ◽  
pp. 149-154 ◽  
Author(s):  
Magda Heras ◽  
Eulália Roig ◽  
Félix Pérez-Villa ◽  
Marco Paz ◽  
Gaspar Melis ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Coronary Blood Flow ◽  
Endogenous Nitric Oxide

Role of Nitric Oxide on Papillary Blood Flow and Pressure Natriuresis

Hypertension ◽  
1995 ◽  
Vol 25 (3) ◽  
pp. 408-414 ◽  
Author(s):  
Francisco J. Fenoy ◽  
Paloma Ferrer ◽  
Luis Carbonell ◽  
Miguel García-Salom
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Pressure Natriuresis

scholarly journals Computational Analysis of Coronary Blood Flow: The Role of Asynchronous Pacing and Arrhythmias

Mathematics ◽  
2020 ◽  
Vol 8 (8) ◽  
pp. 1205
Author(s):  
Timur Gamilov ◽  
Philipp Kopylov ◽  
Maria Serova ◽  
Roman Syunyaev ◽  
Andrey Pikunov ◽  
...  
Keyword(s):  
Heart Rate ◽  
Blood Flow ◽  
Coronary Blood Flow ◽  
Long Qt Syndrome ◽  
Premature Ventricular Contraction ◽  
Cardiac Pacing ◽  
Long Qt ◽  
Computational Evaluation ◽  
Qt Syndrome

In this work we present a one-dimensional (1D) mathematical model of the coronary circulation and use it to study the effects of arrhythmias on coronary blood flow (CBF). Hydrodynamical models are rarely used to study arrhythmias’ effects on CBF. Our model accounts for action potential duration, which updates the length of systole depending on the heart rate. It also includes dependency of stroke volume on heart rate, which is based on clinical data. We apply the new methodology to the computational evaluation of CBF during interventricular asynchrony due to cardiac pacing and some types of arrhythmias including tachycardia, bradycardia, long QT syndrome and premature ventricular contraction (bigeminy, trigeminy, quadrigeminy). We find that CBF can be significantly affected by arrhythmias. CBF at rest (60 bpm) is 26% lower in LCA and 22% lower in RCA for long QT syndrome. During bigeminy, trigeminy and quadrigeminy, respectively, CBF decreases by 28%, 19% and 14% with respect to a healthy case.

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