scholarly journals Discoidin Domain Receptors Role in Human Diseases

2011 ◽  
Vol 3 (4) ◽  
pp. 07-12
Author(s):  
Iker BADIOLA
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Receptors ◽  
Tyrosine Kinase Receptor ◽  
Special Role ◽  
Fibrillar Collagen ◽  
Natural Ligand ◽  
Discoidin Domain Receptors ◽  
Phosphorylation Pattern ◽  
Development Processes ◽  
Discoidin Domain Receptor 1

Discoidin Domain Receptor 1 and Discodin Domain Receptor 2 are the two only members of the DDR family. The DDR family is a Tyrosine Kinase Receptor (TKR) family with some peculiarities compared with other Tyrosine Kinase Receptors such as their natural ligand; which in this case is the fibrillar collagen; or the slow phosphorylation pattern. These peculiarities confer a special role to the receptors present in many diseases development processes as cancer, cirrhosis or lung fibrosis. In this review it is described the overview of the DDRs structure and their role in the different disease development and the possibility to consider them as therapeutic targets.

Enhanced microvascular relaxations to VEGF and bFGF in chronically ischemic porcine myocardium

1996 ◽  
Vol 271 (2) ◽  
pp. H713-H720 ◽  
Author(s):  
F. W. Sellke ◽  
S. Y. Wang ◽  
A. Stamler ◽  
J. J. Lopez ◽  
J. Li ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tyrosine Kinase ◽  
Ischemic Myocardium ◽  
Northern Analysis ◽  
Tyrosine Kinase Receptors ◽  
Tyrosine Kinase Receptor ◽  
Vascular Endothelial ◽  
Yorkshire Pigs ◽  
Relaxation Responses ◽  
Endothelial Growth Factor

Changes in the vascular responses to vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in chronically ischemic myocardium have not been investigated. Ameroid constrictors were placed on the proximal left circumflex (LCX) artery of seven Yorkshire pigs. Seven to nine weeks later, myocardial blood flow in the collateral-dependent LCX region was reduced, compared with that in the normally perfused left anterior descending (LAD) region. Both growth factors elicited significant relaxations of coronary microvessels. Relaxations to both VEGF and bFGF were inhibited in the presence of either NG-nitro-L-arginine or genistein, suggesting that the relaxations are through the tyrosine kinase-mediated release of endothelium-derived nitric oxide. Microvascular relaxations to both VEGF or bFGF were significantly greater in vessels harvested from the collateral-perfused LCX region, compared with those taken from the normally perfused LAD region. However, relaxation to the endothelium-dependent vasodilator ADP, which does not operate through a tyrosine kinase receptor, was reduced in the collateral-perfused region, compared with the normally perfused territory, suggesting a possible link of tyrosine kinase to the enhanced relaxations to VEGF and bFGF in collateral-perfused coronary microvessels. Northern analysis showed increased expression for both VEGF receptors (flk-1, flt-1) as well as the bFGF receptor 1 (FGFR-1) in the collateral-perfused region compared with that in the normally perfused region. This suggests that the increased relaxation responses to VEGF and bFGF in the ischemic myocardium may be related to increased gene expression of the respective tyrosine kinase receptors.

scholarly journals Tyrosine Kinase Receptor Landscape in Lung Cancer: Therapeutical Implications

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
A. Quintanal-Villalonga ◽  
Luis Paz-Ares ◽  
Irene Ferrer ◽  
S. Molina-Pinelo
Keyword(s):  
Lung Cancer ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Receptors ◽  
Tyrosine Kinase Receptor ◽  
Poor Survival ◽  
Advanced Stages ◽  
Novel Biomarkers ◽  
New Biomarkers ◽  
Molecular Nature

Lung cancer is a heterogeneous disease responsible for the most cases of cancer-related deaths. The majority of patients are clinically diagnosed at advanced stages, with a poor survival rate. For this reason, the identification of oncodrivers and novel biomarkers is decisive for the future clinical management of this pathology. The rise of high throughput technologies popularly referred to as “omics” has accelerated the discovery of new biomarkers and drivers for this pathology. Within them, tyrosine kinase receptors (TKRs) have proven to be of importance as diagnostic, prognostic, and predictive tools and, due to their molecular nature, as therapeutic targets. Along this review, the role of TKRs in the different lung cancer histologies, research on improvement of anti-TKR therapy, and the current approaches to manage anti-TKR resistance will be discussed.

scholarly journals Expression of the neurotrophic tyrosine kinase receptors, ntrk1 and ntrk2a, precedes expression of other ntrk genes in embryonic zebrafish

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e10479
Author(s):  
Katie Hahn ◽  
Paul Manuel ◽  
Cortney Bouldin
Keyword(s):  
Spinal Cord ◽  
Tyrosine Kinase ◽  
Sensory Neurons ◽  
Critical Role ◽  
Tyrosine Kinase Receptors ◽  
Tyrosine Kinase Receptor ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression ◽  
Cranial Ganglia

Background The neurotrophic tyrosine kinase receptor (Ntrk) gene family plays a critical role in the survival of somatosensory neurons. Most vertebrates have three Ntrk genes each of which encode a Trk receptor: TrkA, TrkB, or TrkC. The function of the Trk receptors is modulated by the p75 neurotrophin receptors (NTRs). Five ntrk genes and one p75 NTR gene (ngfrb) have been discovered in zebrafish. To date, the expression of these genes in the initial stages of neuron specification have not been investigated. Purpose The present work used whole mount in situ hybridization to analyze expression of the five ntrk genes and ngfrb in zebrafish at a timepoint when the first sensory neurons of the zebrafish body are being established (16.5 hpf). Because expression of multiple genes were not found at this time point, we also checked expression at 24 hpf to ensure the functionality of our six probes. Results At 16.5 hpf, we found tissue specific expression of ntrk1 in cranial ganglia, and tissue specific expression of ntrk2a in cranial ganglia and in the spinal cord. Other genes analyzed at 16.5 hpf were either diffuse or not detected. At 24 hpf, we found expression of both ntrk1 and ntrk2a in the spinal cord as well as in multiple cranial ganglia, and we identified ngfrb expression in cranial ganglia at 24 hpf. ntrk2b, ntrk3a and ntrk3b were detected in the developing brain at 24 hpf. Conclusion These data are the first to demonstrate that ntrk1 and ntrk2a are the initial neurotrophic tyrosine kinase receptors expressed in sensory neurons during the development of the zebrafish body, and the first to establish expression patterns of ngfrb during early zebrafish development. Our data indicate co-expression of ntrk1, ntrk2a and ngfrb, and we speculate that these overlapping patterns indicate relatedness of function.

scholarly journals Compromised Reproductive Function in Adult Female Mice Selectively Expressing Mutant ErbB-1 Tyrosine Kinase Receptors in Astroglia

2003 ◽  
Vol 17 (11) ◽  
pp. 2365-2376 ◽  
Author(s):  
Biao Li ◽  
Zhihui Yang ◽  
Jingwen Hou ◽  
April McCracken ◽  
M. Anita Jennings ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Adult Female ◽  
Sexual Development ◽  
Reproductive Function ◽  
Tyrosine Kinase Receptors ◽  
Tyrosine Kinase Receptor ◽  
Neuronal Function ◽  
Female Mice ◽  
Female Sexual Development ◽  
Lh Releasing Hormone

Abstract The ErbB-1 tyrosine kinase receptor plays critical roles in regulating physiological functions. This receptor-mediated signaling in astroglia has been implicated in controlling female sexual development via activating neurons that release LH-releasing hormone (LHRH), the neuropeptide required for the secretion of LH. It remains unknown whether astroglial ErbB-1 receptors are necessary for maintaining normal adult reproductive function. Here we provide genetic evidence that astroglia-specific and time-controlled disruption of ErbB-1 receptor signaling by expressing mutant ErbB-1 receptors leads to compromised reproduction due to alteration in LHRH neuron-controlled secretion of LH in adult female mice. Therefore, astroglial ErbB-1 receptors are required for controlling LHRH neuronal function and thus maintaining adult reproduction, suggesting that compromised astroglial ErbB-1 signaling may also contribute to reproductive abnormalities in aging females.

Targeting of the EphA4 tyrosine kinase receptor affects dorsal/ventral pathfinding of limb motor axons

Development ◽  
2000 ◽  
Vol 127 (15) ◽  
pp. 3313-3324 ◽  
Author(s):  
F. Helmbacher ◽  
S. Schneider-Maunoury ◽  
P. Topilko ◽  
L. Tiret ◽  
P. Charnay
Keyword(s):  
Tyrosine Kinase ◽  
Muscular Atrophy ◽  
Axonal Guidance ◽  
Limb Bud ◽  
Tyrosine Kinase Receptors ◽  
Tyrosine Kinase Receptor ◽  
Environmental Cues ◽  
Motor Axons ◽  
Dorsal Nerve ◽  
Selection Of

The Eph family of tyrosine kinase receptors has recently been implicated in various processes involving the detection of environmental cues such as axonal guidance, targeted cell migration and boundary formation. We have inactivated the mouse EphA4 gene to investigate its functions during development. Homozygous EphA4 mutant animals show peroneal muscular atrophy correlating with the absence of the peroneal nerve, the main dorsal nerve of the hindlimb. This phenotype is also observed, although with a lower penetrance, in heterozygotes. During normal hindlimb innervation, motor axons converge towards the sciatic plexus region at the base of the limb bud, where they must choose between dorsal and ventral trajectories within the limb. Among the axons emerging from the sciatic plexus, dorsal projections show higher levels of EphA4 protein than ventral axons. In EphA4 mutant mice, presumptive dorsal motor axons fail to enter the dorsal compartment of the limb and join the ventral nerve. Our data therefore suggest that the level of EphA4 protein in growing limb motor axons is involved in the selection of dorsal versus ventral trajectories, thus contributing to the topographic organisation of motor projections.

Radiolabeled Probes Targeting Tyrosine-Kinase Receptors For Personalized Medicine

2014 ◽  
Vol 20 (14) ◽  
pp. 2275-2292 ◽  
Author(s):  
Mohamed Altai ◽  
Anna Orlova ◽  
Vladimir Tolmachev
Keyword(s):  
Personalized Medicine ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Receptors
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