Role of multi-detector computed tomography in congenital heart diseases

This paper presents the survey on different techniques which can be used to detect congenital heart disease using palm patterns. The congenital heart disease is one of the heart diseases which starts from birth. Research works are carried out towards detecting congenital heart disease before symptom appears using palm patterns so that it avoids critical health problems in future. Researchers have collected palm prints from normal people who are not suffering from any kind of heart disease and from patients who are suffering from different types of congenital heart diseases. These palm prints are collected from different hospitals. The palm prints are taken using ink and paper method. These palm patterns are analyzed to determine the role of palm pattern while detection of the disease. Few researchers have considered only triradius of palm and most of the researchers have considered palm patterns such as whorl, loop, arch and hypothenar pattern. In case of triradius, researchers have calculated position of axial triradius and it is categorized into three types. In case of whorl, loop and arch, they have considered how often they appear in palm of normal people and patients. Few researchers have analyzed both left and right hands of normal people and patients.

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The possibilities of computed tomography heart-axis-oriented multiplanar reformations in diagnostics of common arterial trunk

Vestnik of Russian military medical Academy ◽

10.17816/brmma12265 ◽

2018 ◽

Vol 20 (1) ◽

pp. 132-138

Author(s):

G K Sadykova ◽

I S Zheleznyak ◽

V V Ipatov ◽

V V Ryazanov

Keyword(s):

Computed Tomography ◽

Right Ventricle ◽

Congenital Heart ◽

Heart Diseases ◽

Pulmonary Arteries ◽

Common Trunk ◽

Congenital Heart Diseases ◽

Common Arterial Trunk ◽

Arterial Trunk ◽

Multiplanar Reformations

The possibility of using multiplanar reformations oriented on the axis of heart in diagnosing the common arterial trunk with X-ray computed tomography is substantiated. Examination data of 140 patients aged 1-19 days of life, 3030-3890 g body weight with conotruncal congenital heart diseases was analyzed, and common arterial trunk was detected in 7 patients (4 - boys, 3 - girls). In 5 (72%) patients, it developed mainly from the morphological right ventricle, 1 (14%) - completely from the morphologically right ventricle, and 1 more (14%) - evenly located above the ventricles. In four (57%) cases, the trunk valve had three leaflets, in two (28,5%) cases - two, in one (14,5%) case - four. All the patients had mitral-semilunar fibrous prolongation, intraventricular septal defects, doubled coronary arteries system, and the pulmonary arteries had their origin from ascendant part of common trunk. Pulmonary arteries had also their own common trunk in 4 (57%) cases, separate estuary in 3 (43%) cases. Aortic arc abnormalities included dextral aortic arc (2 cases), discontinuity of aortic arc (1 case), discontinuity of fourth aortic arc with persistence of fifth left aortic arc (2 cases). In general, computed tomographic angiocardiography heart-axis-oriented multiplanar reformations permit full and correct assessment of heart and main vessels, which is important for surgical treatment planning in congenital heart diseases.

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Defects in the interventricular and atrial septa: the contribution of the transcription factor GATA6 and the signal molecule NOTCH1

Nauchno-prakticheskii zhurnal «Patogenez» ◽

10.25557/2310-0435.2020.02.64-70 ◽

2020 ◽

pp. 64-70

Author(s):

А.В. Цепокина ◽

А.В. Понасенко ◽

Н.С. Деева ◽

А.В. Шабалдин

Keyword(s):

Congenital Heart ◽

Heart Diseases ◽

Modern Medicine ◽

Gene Interactions ◽

Congenital Heart Diseases ◽

Control Groups ◽

Signal Molecule ◽

Exogenous Factors ◽

And Control

Актуальность: Поиск биологических маркёров, вовлеченных в патогенез врожденных пороков сердца (ВПС), остается актуальным вопросом современной медицины и биологии. Врожденные пороки - мультифакторное заболевание, причинами развития которого является взаимовлияющее действие эндогенных и экзогенных факторов. В настоящее время показана роль генов семейства GATA и NOTCH1 в формировании предрасположенности к развитию врожденных пороков сердца. Материалы и методы: Группу исследования составили 58 детей с диагнозом дефекта межжелудочковой и межпредсердной перегородок, в контрольную группу включены 103 ребенка без данной патологии. Генотипирование проводили полимеразной цепной реакцией в режиме реального времени с использованием TaqMan-зондов. Результаты: Исследование встречаемости генотипов генов GATA6 и NOTCH1 в исследуемой и контрольной группах не показало статистически значимых различий. Однако, анализ межгенных взаимодействий при помощи программы MDR 3.0.2. позволил выделить ряд протективных и рисковых генотипов. Заключение: Несмотря на отсутствие статистически значимых различий по частоте встречаемости генотипов, полученные в ходе анализа межгенных связей сочетания генотипов могут быть связаны с предрасположенностью к развитию ВПС. Background: The search for biological markers involved in the congenital heart diseases pathogenesis remains a topical problem in modern medicine and biology. Congenital heart diseases are a multifactorial disease caused by the mutually affecting effects of endogenous and exogenous factors. Currently, the role of GATA and NOTCH1 gene family in the predisposition to development of congenital heart diseases is shown. Materials and methods: 58 children with a diagnosis of congenital heart diseases (defects in the interventricular and atrial septa) and 103 children without this pathology were included in the study and the control groups, respectively. Genotyping was performed by real-time polymerase chain reaction using TaqMan probes Results: A study of the frequencies of the genotypes in the GATA6 and NOTCH1 genes in the study and control groups showed no statistically significant differences. At the same time, the analysis of gene-gene interactions using MDR 3.0.2 software allows to determine a number of protective and risk genotypes. Conclusion: Despite the absence of significant differences in the frequency of genotypes, combinations of genotypes obtained during the analysis of gene-gene interactions may be associated with a predisposition to the development of congenital heart diseases.

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Submillisievert Multiphasic Coronary Computed Tomography Angiography for Pediatric Patients With Congenital Heart Diseases

Circulation Cardiovascular Imaging ◽

10.1161/circimaging.118.008348 ◽

2019 ◽

Vol 12 (2) ◽

Cited By ~ 5

Author(s):

Julien Le Roy ◽

Hélène Vernhet Kovacsik ◽

Hamid Zarqane ◽

Marie Vincenti ◽

Hamouda Abassi ◽

...

Keyword(s):

Computed Tomography ◽

Computed Tomography Angiography ◽

Congenital Heart ◽

Pediatric Patients ◽

Coronary Computed Tomography Angiography ◽

Heart Diseases ◽

Congenital Heart Diseases ◽

Coronary Computed Tomography

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