scholarly journals The potential protective role of grape seed proanthocyanidin extract against the mixture of carboplatin and thalidomide -induced hepatotoxicity and cardiotoxicity in male rats

2019 ◽  
Vol 2 (3) ◽  
Author(s):  
Mokhtar I Yousef ◽  
Moustafa AFH Mahdy ◽  
Heba M Abdou
Keyword(s):  
Grape Seed ◽  
Protective Role ◽  
Male Rats ◽  
Grape Seed Proanthocyanidin Extract ◽  
Grape Seed Proanthocyanidin

scholarly journals Attenuation of Perfluorooctane Sulfonate-Induced Steatohepatitis by Grape Seed Proanthocyanidin Extract in Mice

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Tao Huang ◽  
Yurong Zhang ◽  
Wenjuan Zhang ◽  
Tingting Lin ◽  
Luoting Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Metabolism ◽  
Perfluorooctane Sulfonate ◽  
Grape Seed ◽  
Protective Role ◽  
Fatty Acid Binding ◽  
Grape Seed Proanthocyanidin Extract ◽  
Tnf Α ◽  
Grape Seed Proanthocyanidin ◽  
Factor Α

Perfluorooctane sulfonate (PFOS), an environmentally persistent pollutant, has been revealed to elicit hepatic toxicity. In the current study, we investigated the protective role of grape seed proanthocyanidin extract (GSPE) against PFOS-caused steatohepatitis in mice. Animals were exposed intragastrically to PFOS (10 mg/kg/day), GSPE (150 mg/kg/day), or their combination. After 21 days of treatment, mice exposed to PFOS exhibited steatosis, oxidative stress, and inflammation in the liver. Nevertheless, simultaneous administration of GSPE resumed the declined serum hepatic enzyme activities and histological abnormalities in PFOS-exposed mice. Furthermore, GSPE supplementation reduced the contents of triglyceride (TG) and total cholesterol (TC) and expression of lipid metabolism-associated genes CD36 and fatty acid-binding protein 4 (FABP4) in the liver of mice treated with PFOS. Moreover, GSPE suppressed the generation of lipid peroxidative product malondialdehyde and restored the activity of superoxide dismutase in the liver of PFOS-exposed mice. In addition, GSPE repressed the PFOS-induced hepatic overproduction of proinflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Our results demonstrate that GSPE attenuates PFOS-caused steatohepatitis in mice by regulating lipid metabolism, oxidative stress, and inflammatory response.

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