scholarly journals A fresh look at W- compound: A potential marker for fetal thyroid function – Fetal to maternal transfer of sulfated thyroid hormone metabolites

2018 ◽  
Vol 3 (1) ◽  
Author(s):  
Sing-Yung Wu ◽  
Christine Ma ◽  
Bi-Xin Xi ◽  
Timothy Synold
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Maternal Transfer ◽  
Compound A ◽  
Potential Marker ◽  
Fetal Thyroid

scholarly journals Fetal Thyroid Hormone Level at Birth Is Associated with Fetal Growth

2011 ◽  
Vol 96 (6) ◽  
pp. E934-E938 ◽  
Author(s):  
Beverley M. Shields ◽  
Beatrice A. Knight ◽  
Anita Hill ◽  
Andrew T. Hattersley ◽  
Bijay Vaidya
Keyword(s):  
Birth Weight ◽  
Thyroid Hormone ◽  
Cord Blood ◽  
Thyroid Function ◽  
Fetal Growth ◽  
Late Gestation ◽  
Third Trimester ◽  
Free T4 ◽  
Skeletal Size ◽  
Fetal Thyroid

Context: Thyroid function is known to play an important role in fetal neurological development, but its role in regulating fetal growth is not well established. Overt maternal and fetal thyroid disorders are associated with reduced birth weight. We hypothesized that, even in the absence of overt thyroid dysfunction, maternal and fetal thyroid function influence fetal growth. Aim: In normal, healthy pregnancies, we aimed to assess whether fetal thyroid hormone at birth (as measured in cord blood) is associated with fetal growth. We also aimed to study whether fetal thyroid hormone at birth is associated with maternal thyroid hormone in the third trimester. Methods: In 616 healthy mother-child pairs, TSH, free T4 (FT4), and free T3 (FT3) were measured in mothers at 28 wk gestation and in umbilical cord blood at birth. Birth weight, length, head circumference, and tricep and bicep skinfold thicknesses were measured on the babies. Results: Cord FT4 was associated with birth weight (r = 0.25; P < 0.001), length (r = 0.17; P < 0.001), and sum of skinfolds (r = 0.19; P < 0.001). There were no associations between birth measurements and either cord TSH or cord FT3. Maternal FT4 and cord FT4 were correlated (r = 0.14; P = 0.0004), and there were weaker negative associations between maternal TSH and cord FT4 (r = −0.08; P = 0.04) and FT3 (r = −0.10; P = 0.01). Conclusion: Associations between cord FT4 and birth size suggest that fetal thyroid function may be important in regulating fetal growth, both of skeletal size and fat. The correlation between third-trimester maternal FT4 and cord FT4 supports the belief that maternal T4 crosses the placenta even in late gestation.

scholarly journals Compound W, a 3,3′-Diiodothyronine Sulfate Cross-Reactive Substance in Serum from Pregnant Women—A Potential Marker for Fetal Thyroid Function

2007 ◽  
Vol 61 (3) ◽  
pp. 307-312 ◽  
Author(s):  
Sing-Yung Wu ◽  
Wen-Sheng Huang ◽  
Eugene Ho ◽  
Elizabeth S C Wu ◽  
Delbert A Fisher
Keyword(s):  
Pregnant Women ◽  
Thyroid Function ◽  
Reactive Substance ◽  
Potential Marker ◽  
Fetal Thyroid

The association between prenatal exposure to organochlorine compounds and neonatal thyroid hormone levels: a systematic review

2020 ◽  
Vol 33 (1) ◽  
pp. 21-33 ◽  
Author(s):  
Mahshid Gheidarloo ◽  
Roya Kelishadi ◽  
Silva Hovsepian ◽  
Mojtaba Keikha ◽  
Mahin Hashemipour
Keyword(s):  
Systematic Review ◽  
Thyroid Hormone ◽  
Organochlorine Pesticides ◽  
Thyroid Function ◽  
Prenatal Exposure ◽  
Thyroid Function Tests ◽  
Hormone Levels ◽  
Fetal Thyroid ◽  
Thyroid Hormone Levels ◽  
Organochlorine Pollutant

AbstractIn this systematic review, the association between prenatal exposure to organochlorine pesticides (OCPs) and neonatal thyroid hormone levels was studied. A systematic search of scientific literature was performed from the PubMed, SCOPUS and ISI web of science electronic bibliographic databases. The search strategy for the review was [(organochlorine OR “organochlorine pesticides” OR “organochlorine pollutants” OR “organochlorine pollutant”) AND (“thyroid hormone” OR triiodothyronine OR Thyroxine OR “fetal thyroid function” OR “thyroid function” OR “Thyroid Stimulating Hormone” AND “prenatal” AND “maternal exposure”)] in English sources. In this review, 305 papers (PubMed: 30; Scopus: 29; ISI: 246) were identified through an electronic database search. Twenty-seven articles were assessed for eligibility, from which 16 qualified articles were selected for the final evaluation. The most common OCP metabolites which were evaluated in order were hexachlorobenzene (HCB) (13 studies), pp-dichlorodiphenyldichloroethylene (pp-DDE) (13 studies), hexachlorocyclohexane (HCH) (10 studies) and dichlorodiphenyltrichlorethane (DDT) (eight studies). A review of the documents related to the association of prenatal exposure of OCPs with fetal or neonatal thyroid function tests provides us with heterogeneous data in this field. Factors such as differences in the studied populations and their area, ethnic and genetic background, time and rate of exposure, possible interaction of other thyroid-disrupting environmental factors and dietary intake of micronutrients such as iodine and/or selenium are considered the main limitations for making an accurate conclusion. For some OCPs including DDT, DDE, HCH and HCB, there are supporting evidences, and it is suggested that their exposure could potentially alter the fetal thyroid function and consequently impair the neurodevelopment process of the infants.

Effects of Maternal Hypothyroidism on the Weight and Thyroid Hormone Content of Rat Embryonic Tissues, before and after Onset of Fetal Thyroid Function*

Endocrinology ◽  
1985 ◽  
Vol 117 (5) ◽  
pp. 1890-1900 ◽  
Author(s):  
GABRIELLA MORREALE DE ESCOBAR ◽  
ROSA PASTOR ◽  
MARIA JESUS OBREGON ◽  
FRANCISCO ESCOBAR DEL REY
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Embryonic Tissues ◽  
Hormone Content ◽  
Before And After ◽  
Fetal Thyroid

Urinary compound W in pregnant women is a potential marker for fetal thyroid function

1998 ◽  
Vol 178 (5) ◽  
pp. 886-891 ◽  
Author(s):  
Sing-yung Wu ◽  
Delbert A. Fisher ◽  
Wen-sheng Huang ◽  
Paolo Beck-Peccoz ◽  
Charles H. Emersone ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Thyroid Function ◽  
Potential Marker ◽  
Fetal Thyroid

scholarly journals DIAGNOSTIC DILEMMA IN DISCORDANT THYROID FUNCTION TESTS DUE TO THYROID HORMONE AUTOANTIBODIES

2017 ◽  
Vol 3 (1) ◽  
pp. e22-e25 ◽  
Author(s):  
Panudda Srichomkwun ◽  
Neal H. Scherberg ◽  
Jasminka Jakšić ◽  
Samuel Refetoff
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Function ◽  
Thyroid Function Tests ◽  
Diagnostic Dilemma ◽  
Thyroid Hormone Autoantibodies ◽  
Function Tests

scholarly journals Placental 5-Deiodinase Activity and Fetal Thyroid Hormone Economy Are Unaffected by Selenium Deficiency in the Rat

1993 ◽  
Vol 34 (3) ◽  
pp. 288-292 ◽  
Author(s):  
Jean-Pierre Chanoine ◽  
Sharon Alex ◽  
Scott Stone ◽  
Shih Lieh Fang ◽  
Irini Veronikis ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Selenium Deficiency ◽  
Deiodinase Activity ◽  
Fetal Thyroid
Sign in / Sign up

Export Citation Format

Share Document