scholarly journals A Review on the Neuroendocrine Regulation of Cytokine Secretion: Possible Modulation of the Cytokine Network by the Pineal Hormone Melatonin and Cannabidiol

2019 ◽  
Vol 2 (2) ◽  
Author(s):  
Paolo Lissoni ◽  
Franco Rovelli ◽  
Giusy Messina ◽  
Alejandra Monzon ◽  
Sonja Pensato ◽  
...  
Keyword(s):  
Cytokine Secretion ◽  
Neuroendocrine Regulation ◽  
Cytokine Network

scholarly journals A Review on the Neuroendocrine Regulation of the Endothelial Cells

2020 ◽  
pp. 1-4
Author(s):  
Paolo Lissoni ◽  
◽  
Franco Rovelli ◽  
Keyword(s):  
Neuroendocrine System ◽  
Neuroendocrine Regulation ◽  
Common Mechanism ◽  
Systemic Diseases ◽  
Cytokine Network ◽  
Pathological Conditions ◽  
Inflammatory Processes ◽  
The Common ◽  
Endothelial Functions ◽  
Inflammatory Action

Today, it is known that inflammation represents the common mechanism of human systemic diseases, including cancer and autoimmunity. Obviously, the endothelial system is involved in all inflammatory processes. Then, the control of the endothelial functions could constitute a new medical strategy to treat several pathological conditions, including ischemic and thrombotic events. Moreover, in addition to the action of angiogenic and anti-angiogenic factors, the endothelial system has been proven to be physiologically under a double control, represent by the cytokine network and the neuroendocrine system. Most cytokines have appeared to exert angiogenic and inflammatory effects, which are balanced by an anti-angiogenic and an anti-inflammatory action exerted by the pineal hormone melatonin (MLT), cannabinoid agents, and the product of ACE2, the angiotensin 1-7 (Ang 1-7). Then, a neuroendocrine approach with MLT, cannabinoids and Ang 1-7 could constitute a new way in the treatment of endothelial alterations and angiogenesis.

scholarly journals A Review on the Neuroendocrine Regulation of the Endothelial Cells

2021 ◽  
pp. 1-4
Author(s):  
Paolo Lissoni ◽  
◽  
Franco Rovelli ◽  
Giusy Messina ◽  
◽  
...  
Keyword(s):  
Neuroendocrine System ◽  
Neuroendocrine Regulation ◽  
Common Mechanism ◽  
Systemic Diseases ◽  
Cytokine Network ◽  
Pathological Conditions ◽  
Inflammatory Processes ◽  
The Common ◽  
Endothelial Functions ◽  
Inflammatory Action

Today, it is known that inflammation represents the common mechanism of human systemic diseases, including cancer and autoimmunity. Obviously, the endothelial system is involved in all inflammatory processes. Then, the control of the endothelial functions could constitute a new medical strategy to treat several pathological conditions, including ischemic and thrombotic events. Moreover, in addition to the action of angiogenic and anti-angiogenic factors, the endothelial system has been proven to be physiologically under a double control, represent by the cytokine network and the neuroendocrine system. Most cytokines have appeared to exert angiogenic and inflammatory effects, which are balanced by an anti-angiogenic and an anti-inflammatory action exerted by the pineal hormone melatonin (MLT), cannabinoid agents, and the product of ACE2, the angiotensin 1-7 (Ang 1-7). Then, a neuroendocrine approach with MLT, cannabinoids and Ang 1-7 could constitute a new way in the treatment of endothelial alterations and angiogenesis.

Inhibition of Pro-Inflammatory Cytokine Secretion by Select Antioxidants in Human Coronary Artery Endothelial Cells

2020 ◽  
Vol 90 (1-2) ◽  
pp. 103-112 ◽  
Author(s):  
Michael J. Haas ◽  
Marilu Jurado-Flores ◽  
Ramadan Hammoud ◽  
Victoria Feng ◽  
Krista Gonzales ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Ascorbic Acid ◽  
Coronary Artery ◽  
Inflammatory Cytokines ◽  
Inflammatory Cytokine ◽  
Culture Media ◽  
Cytokine Secretion ◽  
Human Coronary Artery ◽  
Tnf Α ◽  
Pro Inflammatory Cytokines

Abstract. Inflammatory and oxidative stress in endothelial cells are implicated in the pathogenesis of premature atherosclerosis in diabetes. To determine whether high-dextrose concentrations induce the expression of pro-inflammatory cytokines, human coronary artery endothelial cells (HCAEC) were exposed to either 5.5 or 27.5 mM dextrose for 24-hours and interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor α (TNF α) levels were measured by enzyme immunoassays. To determine the effect of antioxidants on inflammatory cytokine secretion, cells were also treated with α-tocopherol, ascorbic acid, and the glutathione peroxidase mimetic ebselen. Only the concentration of IL-1β in culture media from cells exposed to 27.5 mM dextrose increased relative to cells maintained in 5.5 mM dextrose. Treatment with α-tocopherol (10, 100, and 1,000 μM) and ascorbic acid (15, 150, and 1,500 μM) at the same time that the dextrose was added reduced IL-1β, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1β, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose. However, ebselen treatment reduced IL-1β, IL-6, and IL-8 levels in cells maintained in either 5.5 or 27.5 mM dextrose. IL-2 and TNF α concentrations in culture media were below the limit of detection under all experimental conditions studied suggesting that these cells may not synthesize detectable quantities of these cytokines. These results suggest that dextrose at certain concentrations may increase IL-1β levels and that antioxidants have differential effects on suppressing the secretion of pro-inflammatory cytokines in HCAEC.

THE NEUROENDOCRINE REGULATION OF APPETITE DURING LACTATION

1967 ◽  
Vol 56 (1_Suppl) ◽  
pp. S106
Author(s):  
J. A. Edwardson
Keyword(s):  
Neuroendocrine Regulation
Sign in / Sign up

Export Citation Format

Share Document