scholarly journals Potential efficacy of vaccines and other immunotherapeutic strategies for treatment of an intracerebral tumor

2016 ◽  
Vol 2 (3) ◽  
Author(s):  
Terry Lichtor
Keyword(s):  
Potential Efficacy ◽  
Intracerebral Tumor

Isolated, monocular vertical nystagmus: single symptom of an extensive intracerebral tumor

2011 ◽  
Vol 42 (S 01) ◽  
Author(s):  
V Haug ◽  
M von Rhein ◽  
K Frauenknecht ◽  
J Faber ◽  
B Reitter
Keyword(s):  
Intracerebral Tumor ◽  
Vertical Nystagmus

Bactericidal activity of drugs from Juglans Regia to the microflora of livestock premises in organic pig breeding

2020 ◽  
pp. 113-122
Author(s):  
Serhii Zinoviev ◽  
Andrii Kurman ◽  
Dmytro Bindiug ◽  
Pavlo Grubich ◽  
Liubov Lepeta
Keyword(s):  
Bactericidal Activity ◽  
Juglans Regia ◽  
Herbal Remedies ◽  
Potential Efficacy ◽  
Internal Structures ◽  
Bactericidal Properties ◽  
Experimental Base ◽  
Quality Of Products ◽  
Gram Positive Cocci

The introduction of the newest technologies of organic pig breeding has the basic principle of minimizing the use in pigs of chemicals, trace amounts of which in pig production adversely affect the quality of products and the health of consumers. The transition to herbal remedies, the maximum possible rejection of chemical synthesis products, is inhibited, in the main, by the relatively small spectrum of plant compounds with the investigated activity. According to the results of previous studies, six working solutions of Juglans regia L phytosupply extracts - potential phytosine disinfectants were developed: To investigate the bactericidal activity of the experimental preparations of Juglans regia, flushes were made from the internal structures and technological equipment of the housing of the pig stock of the experimental base v. Takhtaulove. Obtained samples of typical banal microflora of the pig complex were mixed to obtain a bacterial-containing suspension averaged over the concentration of microbial bodies and the spectrum of types of microflora in the microbiota. When cultured on nutrient media, with the superficial sowing of a suspension of banal microflora of a pig in the presence of a potential phytodisinfectant, processes of development of individual colonies of the microflora are observed. The amount and intensity of their development, the degree of inhibition of life, assess the level of bactericidal activity of the extracts. The highest bactericidal and fungicidal activity, and consequently, the potential efficacy as a possible disinfectant in the technology of organic pig breeding was revealed by the extracts of phytosupply Juglans regia L No. 2 (extractant - acetic acid to 5 %, nut of wax ripeness) and 4 (extractant, alcohol 20 % nutrient wax ripeness (proven after obtaining the primary extract of up to 5 % alcohol), which have bactericidal properties against gram-positive cocci and gram-negative sticks, but have a weak effect on the spore-forming bacilli. Key words: organic pig breeding, bactericidal activity, phyto-disinfectant, commonplace typical microflora of a pig complex, phyto row materials, walnut extract.

scholarly journals Continuous and Cyclic Progesterone Differentially Interact with Estradiol in the Regulation of Alzheimer-Like Pathology in Female 3×Transgenic-Alzheimer’s Disease Mice

Endocrinology ◽  
2010 ◽  
Vol 151 (6) ◽  
pp. 2713-2722 ◽  
Author(s):  
Jenna C. Carroll ◽  
Emily R. Rosario ◽  
Angela Villamagna ◽  
Christian J. Pike
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Postmenopausal Women ◽  
Transgenic Mouse Model ◽  
Dependent Behavior ◽  
Potential Efficacy ◽  
Increased Risk ◽  
Neural Interactions ◽  
Β Amyloid ◽  
Insight Into

Depletion of estrogens and progesterone at menopause has been linked to an increased risk for the development of Alzheimer’s disease (AD) in women. A currently controversial literature indicates that although treatment of postmenopausal women with hormone therapy (HT) may reduce the risk of AD, several parameters of HT may limit its potential efficacy and perhaps, even exacerbate AD risk. One such parameter is continuous vs. cyclic delivery of the progestogen component of HT. Recent experimental evidence suggests that continuous progesterone can attenuate neural actions of estradiol (E2). In the present study, we compared the effects of continuous and cyclic progesterone treatment in the presence and absence of E2 in ovariectomized 3×Tg-AD mice, a transgenic mouse model of AD. We found that ovariectomy-induced hormone depletion increases AD-like pathology in female 3×Tg-AD mice, including accumulation of β-amyloid, tau hyperphosphorylation, and impaired hippocampal-dependent behavior. E2 treatment alone prevents the increases in pathology. Continuous progesterone did not affect β-amyloid levels when delivered alone but blocked the Aβ-lowering action of E2. In contrast, cyclic progesterone significantly reduced β-amyloid levels by itself and enhanced rather than inhibited the E2 effects. These results provide new insight into the neural interactions between E2 and progesterone that may prove valuable in optimizing HT regimens in postmenopausal women.

scholarly journals Clinical and immunological effects of mRNA vaccines in malignant diseases

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Annkristin Heine ◽  
Stefan Juranek ◽  
Peter Brossart
Keyword(s):  
Immune Responses ◽  
Messenger Rna ◽  
Immune Escape ◽  
Special Focus ◽  
Potential Efficacy ◽  
Protective Antibodies ◽  
Technological Developments ◽  
Broad Variety ◽  
Antigen Loss

AbstractIn vitro-transcribed messenger RNA-based therapeutics represent a relatively novel and highly efficient class of drugs. Several recently published studies emphasize the potential efficacy of mRNA vaccines in treating different types of malignant and infectious diseases where conventional vaccine strategies and platforms fail to elicit protective immune responses. mRNA vaccines have lately raised high interest as potent vaccines against SARS-CoV2. Direct application of mRNA or its electroporation into dendritic cells was shown to induce polyclonal CD4+ and CD8+ mediated antigen-specific T cell responses as well as the production of protective antibodies with the ability to eliminate transformed or infected cells. More importantly, the vaccine composition may include two or more mRNAs coding for different proteins or long peptides. This enables the induction of polyclonal immune responses against a broad variety of epitopes within the encoded antigens that are presented on various MHC complexes, thus avoiding the restriction to a certain HLA molecule or possible immune escape due to antigen-loss. The development and design of mRNA therapies was recently boosted by several critical innovations including the development of technologies for the production and delivery of high quality and stable mRNA. Several technical obstacles such as stability, delivery and immunogenicity were addressed in the past and gradually solved in the recent years.This review will summarize the most recent technological developments and application of mRNA vaccines in clinical trials and discusses the results, challenges and future directions with a special focus on the induced innate and adaptive immune responses.

Potential efficacy and application of a new statistical meta based-model to predict TBM performance

2021 ◽  
pp. 1-17
Author(s):  
Behrooz Keshtegar ◽  
Mahdi Hasanipanah ◽  
Troung Nguyen-Thoi ◽  
Saffet Yagiz ◽  
Hassan Bakhshandeh Amnieh
Keyword(s):  
Tbm Performance ◽  
Potential Efficacy

scholarly journals IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Qingxiao Song ◽  
Xiaoning Wang ◽  
Xiwei Wu ◽  
Tae Hyuk Kang ◽  
Hanjun Qin ◽  
...  
Keyword(s):  
T Cells ◽  
Graft Versus Host Disease ◽  
Mononuclear Phagocyte ◽  
Mononuclear Phagocytes ◽  
Dependent Manner ◽  
Steroid Resistant ◽  
Host Disease ◽  
Graft Versus Host ◽  
Potential Efficacy ◽  
Ifn Γ

AbstractEfforts to improve the prognosis of steroid-resistant gut acute graft-versus-host-disease (SR-Gut-aGVHD) have suffered from poor understanding of its pathogenesis. Here we show that the pathogenesis of SR-Gut-aGVHD is associated with reduction of IFN-γ+ Th/Tc1 cells and preferential expansion of IL-17−IL-22+ Th/Tc22 cells. The IL-22 from Th/Tc22 cells causes dysbiosis in a Reg3γ-dependent manner. Transplantation of IFN-γ-deficient donor CD8+ T cells in the absence of CD4+ T cells produces a phenocopy of SR-Gut-aGVHD. IFN-γ deficiency in donor CD8+ T cells also leads to a PD-1-dependent depletion of intestinal protective CX3CR1hi mononuclear phagocytes (MNP), which also augments expansion of Tc22 cells. Supporting the dual regulation, simultaneous dysbiosis induction and depletion of CX3CR1hi MNP results in full-blown Gut-aGVHD. Our results thus provide insights into SR-Gut-aGVHD pathogenesis and suggest the potential efficacy of IL-22 antagonists and IFN-γ agonists in SR-Gut-aGVHD therapy.

Novel synthetic aromatic thiourea derivatives and investigations on their cytotoxic potential efficacy

2020 ◽  
Vol 58 (1) ◽  
pp. 40-47
Author(s):  
Ujjayinee Ray ◽  
Franklin John ◽  
Sayeesh Pooppadi ◽  
Jinu George ◽  
Shivangi Sharma ◽  
...  
Keyword(s):  
Cytotoxic Potential ◽  
Thiourea Derivatives ◽  
Potential Efficacy

scholarly journals Doxycycline treatment of high-risk COVID-19-positive patients with comorbid pulmonary disease

2020 ◽  
Vol 14 ◽  
pp. 175346662095105 ◽  
Author(s):  
Paul A. Yates ◽  
Steven A. Newman ◽  
Lauren J. Oshry ◽  
Robert H. Glassman ◽  
Ashton M. Leone ◽  
...  
Keyword(s):  
High Risk ◽  
Pulmonary Disease ◽  
Safety Profile ◽  
Viral Pathogens ◽  
Safety Issues ◽  
Doxycycline Treatment ◽  
Potential Efficacy ◽  
Moderate Disease ◽  
Stage Disease ◽  
Attractive Candidate

Infection with novel SARS-CoV-2 carries significant morbidity and mortality in patients with pulmonary compromise, such as lung cancer, autoimmune disease, and pneumonia. For early stages of mild to moderate disease, care is entirely supportive. Antiviral drugs such as remdesivir may be of some benefit but are reserved for severe cases given limited availability and potential toxicity. Repurposing of safer, established medications that may have antiviral activity is a possible approach for treatment of earlier-stage disease. Tetracycline and its derivatives (e.g. doxycycline and minocycline) are nontraditional antibiotics with a well-established safety profile, potential efficacy against viral pathogens such as dengue fever and chikungunya, and may regulate pathways important in initial infection, replication, and systemic response to SARS-CoV-2. We present a series of four high-risk, symptomatic, COVID-19+ patients, with known pulmonary disease, treated with doxycycline with subsequent rapid clinical improvement. No safety issues were noted with use of doxycycline. Doxycycline is an attractive candidate as a repurposed drug in the treatment of COVID-19 infection, with an established safety profile, strong preclinical rationale, and compelling initial clinical experience described here. The reviews of this paper are available via the supplemental material section.

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