Human malignant and benign human cancer cells and tissues biospectroscopic analysis under synchrotron radiation using anti-cancer nano drugs delivery

In this work, the effect of temperature of the ablation environment on the properties of Cadmium Oxide (CdO) nanoparticles produced by synchrotron radiation is investigated. To produce nanoparticles, synchrotron radiation pulse with 1064 (nm) wavelength is used to emit Cadmium in the human cancer cells, tissues and tumors. All test parameters were kept constant and human cancer cells, tissues and tumors temperature was changed to produce samples at 20°C and 65°C. Then, ATR–FTIR, XRD, TEM and UV–Visible spectroscopy analyses were performed to investigate their properties. The results show that the size of nanoparticles is increased by increase in temperature of ablation environment. In addition, in the current experimental research, Gold (Au)–Cadmium Oxide (CdO) alloy is created at the size of nano. In this regard, same volume of Gold and Cadmium Oxide (CdO) solutions were mixed together and emitted by the synchrotron radiation pulse with wavelength of 532 (nm). The Gold and Cadmium Oxide (CdO) solutions have been produced, separately, using synchrotron radiation ablation process. To produce them, synchrotron radiation pulse with wavelength of 1064 (nm) and pulse width of 7 (ns) and repeating frequency of 5 (Hz) was used. The results show that synchrotron radiation emission with wavelength of 532 (nm) is an appropriate method for producing Gold compounds in the size of nano.

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Momordica charantiaExtract Induces Apoptosis in Human Cancer Cells through Caspase- and Mitochondria-Dependent Pathways

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2012/261971 ◽

2012 ◽

Vol 2012 ◽

pp. 1-11 ◽

Cited By ~ 19

Author(s):

Chia-Jung Li ◽

Shih-Fang Tsang ◽

Chun-Hao Tsai ◽

Hsin-Yi Tsai ◽

Jong-Ho Chyuan ◽

...

Keyword(s):

Cell Death ◽

Cytotoxic Activity ◽

Cancer Cells ◽

Dna Fragmentation ◽

Human Cancer ◽

Momordica Charantia ◽

Carcinoma Cells ◽

Human Cancer Cells ◽

Adenocarcinoma Cells ◽

Anti Cancer

Plants are an invaluable source of potential new anti-cancer drugs.Momordica charantiais one of these plants with both edible and medical value and reported to exhibit anticancer activity. To explore the potential effectiveness ofMomordica charantia, methanol extract ofMomordica charantia(MCME) was used to evaluate the cytotoxic activity on four human cancer cell lines, Hone-1 nasopharyngeal carcinoma cells, AGS gastric adenocarcinoma cells, HCT-116 colorectal carcinoma cells, and CL1-0 lung adenocarcinoma cells, in this study. MCME showed cytotoxic activity towards all cancer cells tested, with the approximate IC50ranging from 0.25 to 0.35 mg/mL at 24 h. MCME induced cell death was found to be time-dependent in these cells. Apoptosis was demonstrated by DAPI staining and DNA fragmentation analysis using agarose gel electrophoresis. MCME activated caspase-3 and enhanced the cleavage of downstream DFF45 and PARP, subsequently leading to DNA fragmentation and nuclear condensation. The apoptogenic protein, Bax, was increased, whereas Bcl-2 was decreased after treating for 24 h in all cancer cells, indicating the involvement of mitochondrial pathway in MCME-induced cell death. These findings indicate that MCME has cytotoxic effects on human cancer cells and exhibits promising anti-cancer activity by triggering apoptosis through the regulation of caspases and mitochondria.

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Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2016.03.068 ◽

2016 ◽

Vol 26 (9) ◽

pp. 2164-2169 ◽

Cited By ~ 3

Author(s):

Nikhil R. Madadi ◽

Amit Ketkar ◽

Narsimha R. Penthala ◽

April C.L. Bostian ◽

Robert L. Eoff ◽

...

Keyword(s):

Cancer Cells ◽

Human Cancer ◽

Human Cancer Cells ◽

Anti Cancer

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An appraisal of cinnamyl sulfonamide hydroxamate derivatives (HDAC inhibitors) for anti-cancer, anti-angiogenic and anti-metastatic activities in human cancer cells

Chemico-Biological Interactions ◽

10.1016/j.cbi.2016.05.008 ◽

2016 ◽

Vol 253 ◽

pp. 112-124 ◽

Cited By ~ 9

Author(s):

Neetinkumar D. Reddy ◽

M.H. Shoja ◽

Subhankar Biswas ◽

Pawan G. Nayak ◽

Nitesh Kumar ◽

...

Keyword(s):

Cancer Cells ◽

Human Cancer ◽

Hdac Inhibitors ◽

Human Cancer Cells ◽

Anti Cancer

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Synthetic sphingolipid analogs and anti-cancer drugs synergistically induced human colon and pancreatic cancer cell death through inhibiting ceramide metabolism

10.1101/2021.10.01.462804 ◽

2021 ◽

Author(s):

Jing Song ◽

Arie Dagan

Keyword(s):

Pancreatic Cancer ◽

Cell Death ◽

Cancer Cells ◽

Human Cancer ◽

Human Colon ◽

Cancer Drugs ◽

Human Cancer Cells ◽

Low Concentrations ◽

Anti Cancer ◽

Sphingolipid Analogs

AbstractCeramide metabolism is a potential target for anti-cancer therapy. Studies show that chemotherapeutic agents can induce apoptosis and it is mediated by ceramide. Synthesized sphingolipid analogs can induce cell death in human lymphocytes and leukemia cells. By screening a group of synthetic sphingolipid analogs, we found that low concentrations of AD2750 and AD2646 induced cell death in human cancer cells by preventing ceramide from converting to sphingomyelin, individually or in combination with commercial cancer drugs. The combination of low concentrations of Taxol and AD2750 or AD2646 significantly increased cell death on human colon cancer cells (HT29). Co-administering low concentrations of Doxorubicin with AD2750 or AD2646 elevated cellular toxicity on human pancreatic cancer cells (CRL1687). This synergistic effect is related to the elevated cellular ceramide. Combining AD2750 or AD2646 with chemotherapy drugs can be used to manipulate ceramide and sphingomyelin metabolism, potentially to affect the growth of human cancer cells and increase the effectiveness of anti-cancer drugs on killing cancer cells.

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