scholarly journals Corneal transplant failure associated with smoking

2017 ◽  
Vol 1 (2) ◽  
Author(s):  
Frederick W. Fraunfelder ◽  
Murugesan Raju ◽  
Austin Strohbehn
Keyword(s):  
Corneal Transplant ◽  
Transplant Failure

Differential effects of primary disease and corneal vascularisation on corneal transplant rejection and survival

2019 ◽  
Vol 104 (5) ◽  
pp. 729-734 ◽  
Author(s):  
Daniel Sibley ◽  
Cathy L Hopkinson ◽  
Stephen J Tuft ◽  
Stephen B Kaye ◽  
Daniel F P Larkin
Keyword(s):  
Cox Regression ◽  
Transplant Rejection ◽  
Bullous Keratopathy ◽  
Corneal Transplant ◽  
Post Transplant ◽  
Weak Evidence ◽  
Previous Infection ◽  
Transplant Failure ◽  
Clinically Significant ◽  
The Uk

AimsTo investigate the relative risk of pretransplant corneal vascularisation on rate of rejection and graft failure within 5 years of surgery when categorised by indication for transplantation.We analysed all adults recorded in the UK transplant registry who had a first cornea transplant for keratoconus (KC), pseudophakic bullous keratopathy (PBK) or previous infection (viral/bacterial/fungal/protozoan) between 1999 and 2017. We analysed the number of quadrants of the recipient cornea vascularised before transplant and type of vascularisation, the interval post-transplant to rejection, if any, and the outcome at 5 years post-transplant. Risk factors for rejection and transplant failure were modelled by multivariable risk-adjusted Cox regression.ResultsCorneal vascularisation was recorded in 10%, 25% and 67% of patients with KC, PBK and infection, respectively. Individuals with PBK had an increased hazard of transplant rejection only when there were more than two quadrants of vascularisation (HR 1.5, p=0.004) when either superficial and/or deep vascularisation was present (HR 1.3 and 1.4, respectively, p=0.004). Individuals who had a transplant for previous infection had an increased hazard of rejection with four quadrants of vascularisation (HR 1.6, p=0.003). There was no risk-adjusted increase in transplant failure associated with vascularisation in any group. There was weak evidence of reduction in risk of rejection and/or failure associated with lamellar compared with penetrating transplantation in KC and PBK in vascularised recipient corneas.ConclusionVascularisation is a risk factor for corneal allograft rejection within 5 years. The indication for transplantation has a clinically significant effect on the magnitude of this risk.

scholarly journals Lymphatic vessels identified in failed corneal transplants with neovascularisation

2018 ◽  
Vol 103 (3) ◽  
pp. 421-427 ◽  
Author(s):  
Michael Adam Diamond ◽  
Sze Wah Samuel Chan ◽  
Xun Zhou ◽  
Yelena Glinka ◽  
Eileen Girard ◽  
...  
Keyword(s):  
In Situ Hybridisation ◽  
Lymphatic Vessels ◽  
Immunoperoxidase Staining ◽  
Corneal Transplant ◽  
Fluorescence In Situ Hybridisation ◽  
Consistent Finding ◽  
Fish Samples ◽  
Corneal Transplants ◽  
Transplant Failure ◽  
Negative Controls

BackgroundCorneal transplant failure with neovascularisation is a leading indication for full-thickness grafts in patients. Lymphangiogenesis is implicated in the pathology of graft failure, and here we systematically evaluate failed human corneal transplants with neovascularisation for the presence of lymphatic vessels.MethodsNine failed grafts with neovascularisation, based on H&E staining with subsequent immunoperoxidase staining for CD31, a blood vessel marker, were selected. Lymphatics were investigated by immunohistochemical and immunofluorescence approaches using podoplanin as a lymphatic marker. In two of nine cases, fluorescence in situ hybridisation (FISH) was used for detection of lymphatic mRNAs including podoplanin, VEGFR-3 and LYVE-1. All immunofluorescence and FISH samples were compared with positive and negative controls and visualised by confocal microscopy.ResultsCorneal neovascularisation was established in all cases by H&E and further confirmed by CD31 immunoreactive profiles. Immunohistochemistry for the podoplanin antibody was positive in all cases and showed morphologies ranging from distinct luminal structures to elongated profiles. Simultaneous immunofluorescence using CD31 and podoplanin showed lymphatic vessels distinct from blood vessels. Podoplanin immunofluorescence was noted in seven of nine cases and revealed clear lumina of varying sizes, in addition to lumen-like and elongated profiles. The presence of lymphatic mRNA was confirmed by FISH studies using a combination of at least two of podoplanin, VEGFR-3 and LYVE-1 mRNAs.ConclusionsThe consistent finding of lymphatic vessels in failed grafts with neovascularisation implicates them in the pathogenesis of corneal transplant failure, and points to the lymphatics as a potential new therapeutic target.

scholarly journals The Effect of ABO Blood Incompatibility on Corneal Transplant Failure in Conditions with Low-risk of Graft Rejection

2009 ◽  
Vol 147 (3) ◽  
pp. 432-438.e3 ◽  
Author(s):  
Steven P. Dunn ◽  
Walter J. Stark ◽  
R. Doyle Stulting ◽  
Jonathan H. Lass ◽  
Alan Sugar ◽  
...  
Keyword(s):  
Graft Rejection ◽  
Low Risk ◽  
Corneal Transplant ◽  
Transplant Failure

Causes of corneal transplant failure: a multicentric study

2021 ◽  
Author(s):  
Alba Gómez‐Benlloch ◽  
Andrea Montesel ◽  
Luis Pareja‐Aricò ◽  
David Mingo‐Botín ◽  
Ralph Michael ◽  
...  
Keyword(s):  
Corneal Transplant ◽  
Multicentric Study ◽  
Transplant Failure

Prevention of corneal transplant failure

1992 ◽  
Vol 55 ◽  
pp. 178
Author(s):  
D.J. Coster ◽  
K.A. Williams
Keyword(s):  
Corneal Transplant ◽  
Transplant Failure

A case of successful using a stromal corneal transplant for therapeutic keratoplasty in a patient with herpetic keratitis

2018 ◽  
Vol 73 (2) ◽  
pp. 56-59
Author(s):  
E. Sereda ◽  
◽  
G. Drozhzhyna ◽  
T. Gaidamaka ◽  
◽  
...  
Keyword(s):  
Herpetic Keratitis ◽  
Corneal Transplant

scholarly journals First report of human infection caused by Colletotrichum chlorophyti occurring in a post-corneal transplant patient with endophthalmitis

2021 ◽  
Vol 32 ◽  
pp. 73-76
Author(s):  
Alberto E. Paniz-Mondolfi ◽  
Steven Agemy ◽  
Connie Cañete-Gibas ◽  
Melissa R. Gitman ◽  
Codrin E. Iacob ◽  
...  
Keyword(s):  
Transplant Patient ◽  
Human Infection ◽  
Corneal Transplant ◽  
First Report
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