scholarly journals Single Dose Cold Blood Cardioplegia in Adult Patients: rationale and technique description

2018 ◽  
Vol 2 (1) ◽  
Author(s):  
Molina GR ◽  
Correa JR ◽  
Rios EG ◽  
Abello SJ
Keyword(s):  
Single Dose ◽  
Adult Patients ◽  
Blood Cardioplegia ◽  
Cold Blood ◽  
Cold Blood Cardioplegia

Custodiol cardioplegia solution compared to cold blood cardioplegia in pediatric cardiac surgery: a single-institution experience

Perfusion ◽  
2019 ◽  
Vol 35 (4) ◽  
pp. 316-322
Author(s):  
Steven Bibevski ◽  
Laura Mendoza ◽  
Mark Ruzmetov ◽  
Kevin Tayon ◽  
Jaime Alkon ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Single Dose ◽  
Left Ventricular Ejection Fraction ◽  
Ejection Fraction ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction ◽  
Blood Cardioplegia ◽  
Cold Blood ◽  
Cold Blood Cardioplegia

Objective: Custodiol is an intracellular, crystalloid cardioplegia solution that is a single-dose alternative to multi-dose cold blood cardioplegia; however, there is scarce data regarding its use in infants and children. The objective of this study was to compare its impact on myocardial function in infants. Methods: Single-center retrospective review including 132 patients <12 months old undergoing biventricular repair. There were 106 patients who received single-dose Custodiol and 27 patients who received multi-dose blood cardioplegia. Demographic and echocardiographic data were compared between the two groups. Results: Patients receiving Custodiol were slightly younger (100 ± 62 days) and lower weight (4.7 ± 1.3 kg) compared to 152 ± 86 days and 5.2 ± 1.3 kg for blood cardioplegia (p < 0.05). The Society of Thoracic Surgeons/European Association for Cardio-Thoracic Surgery Congenital Heart Surgery score was similar between both groups. Average cardiopulmonary bypass time was similar between both groups (Custodiol 93 ± 54 minutes vs. blood 81 ± 44 minutes, p = 0.46) as was aortic cross-clamp time (Custodiol 58 ± 33 minutes vs. cold blood 53 ± 33 minutes, p = 0.62). Pre-operative left ventricular ejection fraction was similar for blood 73 ± 8% versus Custodiol 70 ± 9%, p = 0.21. There was also no intergroup difference in left ventricular ejection fraction 24 hours post op (blood 64 ± 9% vs. Custodiol 65 ± 12%, p = 0.53) or at discharge (blood 66 ± 10% vs. Custodiol 66 ± 11%, p = 0.95). The pre-operative right ventricle function by fractional area change was also similar in blood cardioplegia (46 ± 13%) versus Custodiol (48 ± 9%, p = 0.38) and showed similar drops in parameters in the two groups 24 hours after surgery and at discharge. Conclusion: Single-dose Custodiol is as safe as blood cardioplegia for myocardial protection in congenital cardiac surgery for the cross-clamp times evaluated in this study. Evaluation at longer cross-clamp times would be helpful to determine if there is a greater benefit to single-dose Custodiol versus more repeated doses of blood cardioplegia for longer cross-clamp times.

Intermittent Antegrade Tepid Versus Cold Blood Cardioplegia in Elective Myocardial Revascularization

1998 ◽  
Vol 65 (6) ◽  
pp. 1559-1565 ◽  
Author(s):  
Andrew C Fiore ◽  
Marc T Swartz ◽  
Robert Nevett ◽  
Paul J Vieth ◽  
Robert A Magrath ◽  
...  
Keyword(s):  
Myocardial Revascularization ◽  
Blood Cardioplegia ◽  
Cold Blood ◽  
Cold Blood Cardioplegia

The impact of del Nido cardioplegia solution on blood morphology parameters

Perfusion ◽  
2021 ◽  
pp. 026765912110490
Author(s):  
Krzysztof Sanetra ◽  
Wojciech Domaradzki ◽  
Marek Cisowski ◽  
Rajesh Shrestha ◽  
Krzysztof Białek ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Blood Cell ◽  
Valve Replacement ◽  
Transfusion Rate ◽  
Blood Cardioplegia ◽  
Blood Morphology ◽  
Cold Blood ◽  
Cold Blood Cardioplegia ◽  
Morphology Parameters

Background: Crystalloid cardioplegic solutions are believed to reduce hemoglobin significantly and increase the transfusion rate. However, recent reports indicate that the del Nido cardioplegia may preserve blood morphology parameters. Methods: In “The del Nido versus cold blood cardioplegia in aortic valve Replacement” trial patients undergoing aortic valve replacement were randomized into the del Nido (DN) or cold blood cardioplegia (CB) group. For the subanalysis, patients who underwent blood transfusions were excluded from the study. Red blood cell (RBC) count, hemoglobin, white blood cell (WBC) count and platelet (PLT) count were measured before the surgery, 24-, 48-, and 96 hours postoperatively. Furthermore, percental variation in first-last measure was compared in groups. In addition, indexed normalized ratio (INR) and activated partial thromboplastin time (aPTT) were compared preoperatively and 24 hours after the surgery. Results: Eighteen (24%) patients from the del Nido group and 22 (29.3%) patients from the CB group received blood product transfusions (p = 0.560) and were excluded from further analysis. As such, 57 patients remained in DN group and 53 patients remained in CB group. No difference was found in RBC, hemoglobin, WBC, and platelet count in time intervals. Percental variation in first-last measure revealed higher fall in RBC (p = 0.0024) and hemoglobin (p = 0.0028) in the CB group. No difference was shown in preoperative and 24-hour postoperative INR and aPTT. Conclusions: The del Nido cardioplegia does not decrease blood morphology parameters when compared to cold blood cardioplegia and may be used alternatively regardless of bleeding and coagulopathy risk.

Myocardial protection during aortic surgery: comparison between Bretschneider-HTK and cold blood cardioplegia

Perfusion ◽  
2011 ◽  
Vol 26 (5) ◽  
pp. 427-433 ◽  
Author(s):  
G Scrascia ◽  
P Guida ◽  
C Rotunno ◽  
M De Palo ◽  
F Mastro ◽  
...  
Keyword(s):  
Myocardial Protection ◽  
Aortic Surgery ◽  
Blood Cardioplegia ◽  
Cold Blood ◽  
Cold Blood Cardioplegia
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