scholarly journals The role of non-drug strategies in reducing the risk of cardiovascular complications in women with metabolic syndrome during the menopausal transition

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Berikhanova RR ◽  
Minenko IA ◽  
Bondarev SA
Keyword(s):  
Metabolic Syndrome ◽  
Cardiovascular Complications ◽  
Menopausal Transition

Patient with hypertension, metabolic disorder and benign prostatic hyperplasia in the primary care physician’s office – the role of doxazosin

2021 ◽  
Vol 14 (3) ◽  
pp. 269-273
Author(s):  
Anna Nowak ◽  
Joanna Jarosz-Popek ◽  
Marek Postuła
Keyword(s):  
Primary Care ◽  
Metabolic Syndrome ◽  
Clinical Trials ◽  
Risk Factor ◽  
Benign Prostatic Hyperplasia ◽  
Adrenergic Receptor ◽  
Cardiovascular Complications ◽  
Prostatic Hyperplasia ◽  
Pleiotropic Action

In recent years, the therapy for patients with metabolic syndrome, which is a risk factor for cardiovascular complications, has become a challenge. Doxazosin – a selective α-adrenergic receptor antagonist, has emerged as a promising research target in the context of metabolic syndrome. It is pleiotropic action contributes to the reduction of metabolic syndrome indices. The results of clinical trials allow the construction of a promising, highly effective, and above all safe therapy in this group of patients.

Glucocorticoid-induced metabolic syndrome: establishing the role of AgRP

2018 ◽  
Author(s):  
Charlotte Sefton ◽  
Erika Harno ◽  
Alison Davies ◽  
Tiffany-Jayne Allen ◽  
Jonathan R Wray ◽  
...  
Keyword(s):  
Metabolic Syndrome

The role of omentin in inflammation and metabolic syndrome risk assessment in women with PCO-S

2019 ◽  
Author(s):  
Iwona Zieleń-Zynek ◽  
Joanna Kowalska ◽  
Nowak Justyna ◽  
Barbara Zubelewicz-Szkodzińska
Keyword(s):  
Risk Assessment ◽  
Metabolic Syndrome

Role of genetic factors in the development of hypertension in young patients with metabolic syndrome

2020 ◽  
pp. 23-32
Author(s):  
Elena Korneeva ◽  
Mikhail Voevoda ◽  
Sergey Semaev ◽  
Vladimir Maksimov
Keyword(s):  
Metabolic Syndrome ◽  
High Risk ◽  
Arterial Hypertension ◽  
Genetic Factors ◽  
Young Patients ◽  
Integrin Αiibβ3 ◽  
Ace Gene ◽  
The Metabolic Syndrome

Results of the study related to polymorphism of ACE gene (rs1799752)‎, integrin αIIbβ3, and CSK gene (rs1378942) influencing development of arterial hypertension in young patients with metabolic syndrome are presented. Hypertension as a component of the metabolic syndrome was detected in 15.0% of young patients. Prevalence of mutant alleles of the studied genes among the examined patients was quite high, so homozygous DD genotype was found in 21.6%, and mutant D allele of the ACE gene in 47.4%. A high risk of hypertension in patients with MS was detected in carriers of the T allele of the CSK (rs1378942) gene – 54.8%, which was most often observed in a combination of polymorphic ACE and CSK gene loci (p = 0.0053).

The Potential Role of Antioxidants in Metabolic Syndrome

2016 ◽  
Vol 22 (7) ◽  
pp. 859-869 ◽  
Author(s):  
Bianca Martins Gregório ◽  
Diogo Benchimol De Souza ◽  
Fernanda Amorim de Morais Nascimento ◽  
Leonardo Matta ◽  
Caroline Fernandes-Santos
Keyword(s):  
Metabolic Syndrome ◽  
Potential Role

Cardiovascular Complications in Patients with Klinefelter’s Syndrome

2020 ◽  
Vol 26 (43) ◽  
pp. 5556-5563
Author(s):  
Franz Sesti ◽  
Riccardo Pofi ◽  
Carlotta Pozza ◽  
Marianna Minnetti ◽  
Daniele Gianfrilli ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Klinefelter Syndrome ◽  
Subclinical Atherosclerosis ◽  
Cardiovascular Complications ◽  
High Risk Population ◽  
Metabolic Disturbances ◽  
Future Studies ◽  
Increased Risk ◽  
Chromosome Disorder

More than 70 years have passed since the first description of Klinefelter Syndrome (KS), the most frequent chromosome disorder causing male infertility and hypogonadism. KS is associated with increased cardiovascular (CV) mortality due to several comorbidities, including hypogonadism, as well as metabolic syndrome and type 2 diabetes, which are highly prevalent in these patients. Aside from metabolic disturbances, patients with KS suffer from both acquired and congenital CV abnormalities, cerebrovascular thromboembolic disease, subclinical atherosclerosis and endothelial dysfunction, which may all contribute to increased CV mortality. The mechanisms involved in this increased risk of CV morbidity and mortality are not entirely understood. More research is needed to better characterise the CV manifestations, elucidate the pathophysiological mechanisms and define the contribution of testosterone replacement to restoring CV health in KS patients. This review explores the complex association between KS, metabolic syndrome and CV risk in order to plan future studies and improve strategies to reduce mortality in this high-risk population.

Dietary Carotenoids in Managing Metabolic Syndrome and Role of PPARs in the Process

2020 ◽  
Vol 16 (6) ◽  
pp. 846-853
Author(s):  
Raghunandan Purohith ◽  
Nagendra P.M. Nagalingaswamy ◽  
Nanjunda S. Shivananju
Keyword(s):  
Metabolic Syndrome ◽  
Dietary Intervention ◽  
Bioactive Constituents ◽  
Dietary Antioxidants ◽  
Predisposing Factor ◽  
Beneficial Effects ◽  
Pathological Conditions ◽  
Established Relationship ◽  
Comprehensive Study

Metabolic syndrome is a collective term that denotes disorder in metabolism, symptoms of which include hyperglycemia, hyperlipidemia, hypertension, and endothelial dysfunction. Diet is a major predisposing factor in the development of metabolic syndrome, and dietary intervention is necessary for both prevention and management. The bioactive constituents of food play a key role in this process. Micronutrients such as vitamins, carotenoids, amino acids, flavonoids, minerals, and aromatic pigment molecules found in fruits, vegetables, spices, and condiments are known to have beneficial effects in preventing and managing metabolic syndrome. There exists a well-established relationship between oxidative stress and major pathological conditions such as inflammation, metabolic syndrome, and cancer. Consequently, dietary antioxidants are implicated in the remediation of these complications. The mechanism of action and targets of dietary antioxidants as well as their effects on related pathways are being extensively studied and elucidated in recent times. This review attempts a comprehensive study of the role of dietary carotenoids in alleviating metabolic syndromewith an emphasis on molecular mechanism-in the light of recent advances.

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