scholarly journals Low levels of HDL-cholesterol and peripheral artery disease: Protocol for systematic review and meta-analysis

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Leonardo Roever ◽  
Elmiro Santos Resende ◽  
Angélica Lemos Debs Diniz ◽  
Nilson Penha-Silva ◽  
João Lucas O’Connell ◽  
...  
Keyword(s):  
Systematic Review ◽  
Peripheral Artery Disease ◽  
Meta Analysis ◽  
Hdl Cholesterol ◽  
Peripheral Artery ◽  
Low Levels ◽  
Artery Disease

Antiphospholipid antibodies and lower extremity peripheral artery disease: A systematic review and meta-analysis

2020 ◽  
Vol 50 (6) ◽  
pp. 1291-1298
Author(s):  
Mira Merashli ◽  
Tommaso Bucci ◽  
Daniele Pastori ◽  
Pasquale Pignatelli ◽  
Vincenzo Marottoli ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lower Extremity ◽  
Peripheral Artery Disease ◽  
Antiphospholipid Antibodies ◽  
Meta Analysis ◽  
Peripheral Artery ◽  
Artery Disease

Statins and Major Adverse Limb Events in Patients with Peripheral Artery Disease: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 120 (05) ◽  
pp. 866-875 ◽  
Author(s):  
Daniele Pastori ◽  
Alessio Farcomeni ◽  
Alberto Milanese ◽  
Francesco Del Sole ◽  
Danilo Menichelli ◽  
...  
Keyword(s):  
Systematic Review ◽  
Peripheral Artery Disease ◽  
Meta Analysis ◽  
Graft Occlusion ◽  
Peripheral Artery ◽  
All Cause Mortality ◽  
Statin Prescription ◽  
Secondary Endpoints ◽  
Artery Disease ◽  
The Impact

Abstract Background Statins are guidelines recommended in patients with peripheral artery disease (PAD) for the prevention of cardiovascular (CV) events. Comprehensive meta-data on the impact of statins on major adverse limb events (MALE) in PAD patients are lacking. We examined the association of statin use with MALE in patients with PAD. Methods We performed a systematic review (registered at PROSPERO: number CRD42019137111) and metanalysis of studies retrieved from PubMed (via MEDLINE) and Cochrane (CENTRAL) databases addressing the impact of statin on MALE including amputation and graft occlusion/revascularization. Secondary endpoints were all-cause death, composite CV endpoints, CV death, and stroke. Results We included 51 studies with 138,060 PAD patients, of whom 48,459 (35.1%) were treated with statins. The analysis included 2 randomized controlled trials, 20 prospective, and 29 retrospective studies. Overall, 11,396 MALE events, 21,624 deaths, 4,852 composite CV endpoints, 4,609 CV deaths, and 860 strokes were used for the analysis. Statins reduced MALE incidence by 30% (pooled hazard ratio [HR]: 0.702; 95% confidence interval [CI]: 0.605–0.815) and amputations by 35% (HR: 0.654; 95% CI: 0.522–0.819), all-cause mortality by 39% (pooled HR: 0.608, 95% CI: 0.543–0.680), CV death by 41% (HR: 0.594; 95% CI: 0.455–0.777), composite CV endpoints by 34% (pooled HR: 0.662; 95% CI: 0.591–0.741) and ischemic stroke by 28% (pooled HR: 0.718; 95% CI: 0.620–0.831). Conclusion Statins reduce the incidence of MALE, all-cause, and CV mortality in patients with PAD. In PAD, a high proportion of MALE events and deaths could be prevented by implementing a statin prescription in this patient population.

scholarly journals Epicardial adipose tissue and peripheral artery disease: protocol for systematic review and meta-analysis

2018 ◽  
Vol 4 (4) ◽  
Author(s):  
Leonardo Roever ◽  
Elmiro Santos Resende ◽  
Angelica LemosDebs Diniz ◽  
Nilson Penha-Silva ◽  
Joao Lucas O'Connell ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adipose Tissue ◽  
Peripheral Artery Disease ◽  
Epicardial Adipose Tissue ◽  
Meta Analysis ◽  
Peripheral Artery ◽  
Artery Disease
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