scholarly journals Modulation of trophism and fiber type gene expression in denervated muscle activated by different patterns of electrical stimulation. Role of muscle fiber regeneration revisited in 2017

2017 ◽  
Vol 2 (1) ◽  
Author(s):  
Andrea Marcante ◽  
Alfonc Baba ◽  
Ugo Carraro ◽  
Helmut Kern ◽  
Stefan Loefler ◽  
...  
Keyword(s):  
Gene Expression ◽  
Electrical Stimulation ◽  
Muscle Fiber ◽  
Fiber Type ◽  
Denervated Muscle ◽  
Type Gene ◽  
Muscle Fiber Regeneration

scholarly journals Effect of muscle-fiber type on glycogenin-1 gene expression and its relationship with the glycolytic potential and pH of pork

2013 ◽  
Vol 12 (3) ◽  
pp. 3383-3390 ◽  
Author(s):  
S.-H. Zhang ◽  
L. Zhu ◽  
Z.-H. Wu ◽  
Y. Zhang ◽  
G.-Q. Tang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Muscle Fiber ◽  
Fiber Type ◽  
Muscle Fiber Type ◽  
Glycolytic Potential

scholarly journals Calcineurin plays a modulatory role in loading-induced regulation of type I myosin heavy chain gene expression in slow skeletal muscle

2009 ◽  
Vol 297 (4) ◽  
pp. R1037-R1048 ◽  
Author(s):  
Clay E. Pandorf ◽  
Weihua H. Jiang ◽  
Anqi X. Qin ◽  
Paul W. Bodell ◽  
Kenneth M. Baldwin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Fiber Type ◽  
Hindlimb Suspension ◽  
Chain Gene ◽  
Type I ◽  
Thyroid State

The role of calcineurin (Cn) in skeletal muscle fiber-type expression has been a subject of great interest because of reports indicating that it controls the slow muscle phenotype. To delineate the role of Cn in phenotype remodeling, particularly its role in driving expression of the type I myosin heavy chain (MHC) gene, we used a novel strategy whereby a profound transition from fast to slow fiber type is induced and examined in the absence and presence of cyclosporin A (CsA), a Cn inhibitor. To induce the fast-to-slow transition, we first subjected rats to 7 days of hindlimb suspension (HS) + thyroid hormone [triiodothyronine (T3)] to suppress nearly all expression of type I MHC mRNA in the soleus muscle. HS + T3 was then withdrawn, and rats resumed normal ambulation and thyroid state, during which vehicle or CsA (30 mg·kg−1·day−1) was administered for 7 or 14 days. The findings demonstrate that, despite significant inhibition of Cn, pre-mRNA, mRNA, and protein abundance of type I MHC increased markedly during reloading relative to HS + T3 ( P < 0.05). Type I MHC expression was, however, attenuated by CsA compared with vehicle treatment. In addition, type IIa and IIx MHC pre-mRNA, mRNA, and relative protein levels were increased in Cn-treated compared with vehicle-treated rats. These findings indicate that Cn has a modulatory role in MHC transcription, rather than a role as a primary regulator of slow MHC gene expression.

scholarly journals The role of Sox6 in zebrafish muscle fiber type specification

2015 ◽  
Vol 5 (1) ◽  
pp. 2 ◽  
Author(s):  
Harriet E Jackson ◽  
Yosuke Ono ◽  
Xingang Wang ◽  
Stone Elworthy ◽  
Vincent T Cunliffe ◽  
...  
Keyword(s):  
Muscle Fiber ◽  
Fiber Type ◽  
Muscle Fiber Type ◽  
Type Specification

Neuromuscular Development in Neonates and Postnatal Infants: Implications for Neuromuscular Electrical Stimulation Therapy for Dysphagia

2019 ◽  
Vol 62 (8) ◽  
pp. 2575-2583 ◽  
Author(s):  
Hannah E. Epperson ◽  
Mary J. Sandage
Keyword(s):  
Electrical Stimulation ◽  
Muscle Fiber ◽  
Fiber Type ◽  
Pediatric Population ◽  
Young Infant ◽  
Neuromuscular Electrical Stimulation ◽  
Muscle Fiber Type ◽  
Current Evidence ◽  
Future Research ◽  
Neuromuscular Development

Purpose The aim of the current study was to review neuromuscular development, summarize the current body of evidence describing the use of neuromuscular electrical stimulation (NMES) therapy in infants, and identify possible contraindications for the use of NMES in the neonate and young infant. Method After a review of the literature describing neuromuscular development, we created a timeline of the developmental processes. Key milestones were determined, and a literature search was conducted to identify potential effects of electrical stimulation on this process. Results Current evidence supporting the use of NMES in the pediatric population is limited and of poor quality. Contraindications of the use of NMES in the neonate and young infant were identified, including (a) inhibited expression of the neural cell adhesion molecule that is vital for neuromuscular development, (b) alteration of muscle fiber type metabolic profile away from intended muscle fiber type morphology, and (c) interruption of postsynaptic acetylcholine receptor synthesis during neuromuscular junction development. Conclusion The use of NMES for the treatment of dysphagia in the neonate and young infant may influence early neuromuscular development in a manner that is not currently well understood. Future research is needed to further understand the effects of NMES on the developing neuromuscular system.

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