scholarly journals Reasons for hospitalization of HIV-positive patients in Riga East clinical University hospital, Latvia, 2014

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Seikals K ◽  
Sture G
Keyword(s):  
University Hospital ◽  
Hiv Positive

Antimalarial drug resistance markers in human immunodeficiency virus (HIV)-positive and HIV-negative adults with asymptomatic malaria infections in Port Harcourt, Nigeria

2021 ◽  
Author(s):  
Ifeyinwa Chijioke-Nwauche ◽  
Mary C Oguike ◽  
Chijioke A Nwauche ◽  
Khalid B Beshir ◽  
Colin J Sutherland
Keyword(s):  
Human Immunodeficiency Virus ◽  
Drug Resistance ◽  
Drug Susceptibility ◽  
Blood Film ◽  
University Hospital ◽  
Hiv Positive ◽  
Asymptomatic Malaria ◽  
Immunodeficiency Virus ◽  
Before And After ◽  
Hiv Negative

Abstract Background In Nigeria, indiscriminate use of antimalarial drugs may contribute to the threat of drug resistance, but this has not been evaluated among people living with human immunodeficiency virus (HIV). Methods HIV-positive adults attending a university hospital HIV clinic and HIV-negative adult volunteers from the university hospital community with a positive blood film were treated with artemether–lumefantrine. Parasite DNA from before and after treatment was polymerase chain reaction amplified to identify molecular markers of drug susceptibility. Results The pfcrt76T genotype was prevalent among both HIV-positive and HIV-negative participants (78.6% and 68.2%, respectively). Three new mutations in the pfmdr1 gene—F73S, S97L and G165R—and the uncommon pfdhps S436F variant were detected, whereas pfdhps K540E and pfdhfr I164L were absent. The A437G allele of pfdhps predominated (62/66 [94%]). The I431 V mutation was found in 19 of 66 pretreatment pfdhps sequences (28.8%). The pfmdr1 86N allele was significantly more common at day 3 post-treatment than at baseline (odds ratio 8.77 [95% confidence interval 1.21 to 380]). Conclusions We found evidence of continued chloroquine use among HIV-positive individuals. Selection for the pfmdr1 86N after artemether–lumefantrine treatment was observed, indicating a possible threat to antimalarial efficacy in the study area. The complexity of pfdhps haplotypes emphasises the need for careful monitoring of anti-folate susceptibility in Nigeria.

The Continuous Surveillance of InSTI resistance could be an important Public Health Tool in the Fight against HIV Infection

2021 ◽  
Vol 19 ◽  
Author(s):  
Giuseppa Visalli ◽  
Alessio Facciolà ◽  
Maria Giovanna Costanzo ◽  
Angela Di Pietro
Keyword(s):  
Drug Resistance ◽  
Hiv Infection ◽  
Hiv Treatment ◽  
Large Cohort ◽  
University Hospital ◽  
Hiv Positive ◽  
Percentage Increase ◽  
Resistance Mutations ◽  
Hiv Test ◽  
Resistance Tests

Aims: To evaluate the frequency of the InSTIs mutations in a large cohort of HIV-infected people. Background: The Highly Active Anti-Retroviral Therapy (HAART) allow turning HIV infection from a fatal disease to a chronic infection and Integrase Strand Transfer Inhibitors (InSTIs) represent the cornerstone of this treatment. However, the spread of HIV-1 drug resistance mutations represents an emerging threat to the long-term success of HIV treatment programs. Objectives: To evaluate the trend of the HIV drug resistance to InSTIs in a large cohort of HIV-positive people in order to assess the risk represented by these subjects in the spread of the HIV infection to the community. Methods: A cross-sectional study was conducted analysing all the InSTIs resistance tests performed in HIV positive subjects in the period 2017-2019 by the HIV Laboratory of the University Hospital "Gaetano Martino" of Messina, Italy. Results: In 2017-2019, 252 InSTIs resistance tests were performed of which 59 (23.4%), 88 (34.9%) and 105 (41.7%) respectively in the three considered years. Overall, 28 (11.1%) samples showed resistance to at least one of the four InSTIs. We observed a significant percentage increase of 95% about the resistance to all the four drugs. Conclusion: Because the InSTI resistance is not rare, a continuous surveillance can represent nowadays, together with an incessant health education and a wide offer of the HIV test, the most important tool in the fight against HIV infection.

scholarly journals Prevalence, Antimicrobial Susceptibility Pattern of Bacterial Isolates, and Associated Factors of Urinary Tract Infections among HIV‐Positive Patients at Hiwot Fana Specialized University Hospital, Eastern Ethiopia

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Dadi Marami ◽  
Senthilkumar Balakrishnan ◽  
Berhanu Seyoum
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Antimicrobial Susceptibility ◽  
University Hospital ◽  
Hiv Positive ◽  
Bacterial Isolates ◽  
E Coli ◽  
Antimicrobial Susceptibility Pattern ◽  
Tract Infections

Urinary tract infection remains a major public health problem in developing countries, where there are limited health-care services. Its prevalence is fueled by human immunodeficiency virus (HIV) infection. The emergence of antimicrobial resistance is now widespread and poses a serious clinical threat. This study investigated the prevalence, antimicrobial susceptibility pattern of bacterial isolates, and associated factors of urinary tract infections among HIV-positive adult patients. A cross-sectional study was conducted among 350 randomly selected HIV-positive patients at Hiwot Fana Specialized University Hospital from February to March 2016. Data were collected using a structured questionnaire. Clean-catch midstream urine samples were collected aseptically and examined using the recommended culture methods. Antimicrobial susceptibility testing was performed using the Kirby–Bauer disk diffusion technique. Data were analyzed using Statistical Package for the Social Sciences version 21.0. The logistic regression models were used to explore the predictors of the outcome. A p value < 0.05 was considered statistically significant. The overall prevalence of urinary tract infection was 18% (95% CI: 15.34–22.63). Individuals with age 35–44 years (Adjusted odds ratio (AOR): 4.07; 95% CI: 1.09, 5.10), income less than 46.7 USD (AOR: 2.76; 95% CI: 1.15, 6.07), and a CD4+ count less than 200 cells/mm3 (AOR: 2.07; 95% CI: 1.15, 3.73) had higher odds of UTI. Escherichia coli (38.1%), Klebsiella pneumoniae (23.8%), and Staphylococcus aureus (11.1%) were the predominant causes of urinary tract infection. E. coli was resistant to ampicillin (95.8%), ceftazidime (95.8%), cotrimoxazole (95.8%), amoxicillin (91.7%), ceftriaxone (87.5%), and tetracycline (87.2%). Multidrug resistance was observed in 46% of the isolates. The prevalence of urinary tract infection in this study was high compared to the previous reports in Ethiopia. Age 35–44 years, income less than 46.7 USD, and a CD4+ count < 200 cells/mm3 increase the odds of urinary tract infection. The most common isolates were E. coli, K. pneumoniae, and S. aureus. Almost half of the isolates were multidrug resistant. Actions to help mitigate the further spread of resistance are urgently needed in the study area.

scholarly journals Changes in bloodstream infections in HIV positive patients in a university hospital in Spain (1995–1997)

2002 ◽  
Vol 6 (1) ◽  
pp. 17-22 ◽  
Author(s):  
MaL. Pedro-Botet ◽  
J.M. Mòdol ◽  
X. Vallès ◽  
J. Romeu ◽  
N. Sopena ◽  
...  
Keyword(s):  
Bloodstream Infections ◽  
University Hospital ◽  
Hiv Positive

scholarly journals Knowledge, Attitudes, and Practices of HIV-Positive Adolescents Related to HIV/AIDS Prevention in Abidjan (Côte d’Ivoire)

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Azagoh-Kouadio Richard ◽  
Yeboua Kossonou Roland ◽  
Yao Kouassi Christian ◽  
Kouassi-Kouadio Amenan Cécile ◽  
Aholi Jean Michel ◽  
...  
Keyword(s):  
Participation Rate ◽  
Unprotected Sex ◽  
Sub Saharan Africa ◽  
University Hospital ◽  
Hiv Positive ◽  
Attitudes And Practices ◽  
Attitude And Practice ◽  
Knowledge Attitude And Practice ◽  
Knowledge Attitudes And Practices ◽  
Hiv Aids

Introduction. In sub-Saharan Africa, many adolescents living with HIV adopt behaviors and practices at risk of transmitting this infection. The aim of the study was to assess the knowledge, attitudes, and practices of HIV-positive adolescents regarding the transmission of HIV for the prevention of this disease. Methods. Knowledge Attitude Practical Survey (KAP) conducted from June 20 to August 22, 2018 in pediatrics at the University Hospital of Treichville. It included consenting HIV-positive adolescents followed up in the voluntary testing counseling unit. The variables studied related to sociodemographic aspects, knowledge, attitude, and practice relating to the transmission of HIV. The analysis was descriptive. Results. The active queue was 349 children, including 210 adolescents. Fifty adolescents (22 boys and 28 girls) participated in the study, a participation rate of 24%. The average age of the participants was 16 years (extreme 10 and 19 years). The respondent was an orphan (38%), a secondary school (58%), and separated living parents in 42%. He stated that he did not know he was infected in 62%, and that he had sex with at least one partner in 54%. He knew the modes of transmission and the means of prevention in 72% of the cases. He knew that an HIV-positive adolescent could transmit the disease in 68%, and that HIV/AIDS was incurable in 40%. 42% of respondents said that an infected person on ARVs was contagious. Twenty-nine respondents who had a partner said they had unprotected sex in 58%. All of the adolescents surveyed said that they did not talk to friends and family about HIV. Conclusion. The level of knowledge, attitude, and practice of HIV-positive adolescents regarding HIV/AIDS transmission is insufficient. We suggest setting up a therapeutic HIV/AIDS education program for these adolescents.

scholarly journals Epidemiological and diagnostic aspects of spontaneous miscarriage in the department of gynecology-obstetric of the university hospital of Treichville in Abidjan

2020 ◽  
Vol 10 (1) ◽  
pp. 1
Author(s):  
Ignace N. Yao ◽  
Jean Marc L. Dia ◽  
Michelle M. Menin ◽  
Mouhedeen A. Oyelade ◽  
Corneille T. Saki ◽  
...  
Keyword(s):  
Chromosomal Abnormalities ◽  
Cross Sectional Study ◽  
University Teaching ◽  
University Hospital ◽  
Pathological Examination ◽  
Hiv Positive ◽  
Cross Sectional ◽  
History Of ◽  
Early Miscarriage ◽  
The University

Background: Describe the epidemiological and diagnostic of spontaneous aspects of early miscarriage in the department of the Gynecology Obsteric of Treichville University Teaching Hospital of   Treichville in Abidjan.Methods: A cross-sectional study was performed from January 2016 to March 2017 on patients received for an early miscarriage (gestational age less than 14 weeks of amenorrhea).Results: We recorded 337 cases of miscarriage and it shows that miscarriage was frequently estimated at 58 percent. Our patients had a average age of 32.9 years, 60.4 percent of them with primary education and 48 percent are housewives. The patients were paucigestes in 46 percent and the majority of them were nulliparous (62 percent). 6 percent with history of high blood pressure; diabetes (3 percent) and 31 percent of patients were HIV positive. Patients had pelvic pain at the admission in (55 percent). A miscarriage appears before 10 weeks of amenorrhea (76.1 percent) of cases. Ultrasound showed ovular debris (47 percent) of patients and (55.4 percent) were chromosomal abnormalities on anatomy-pathological examination.Conclusions: Spontaneous abortions are common and pathological examination is essential for diagnosis.

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