scholarly journals The Extracorporeal Bio-Xeno Perfusion (myelo-timo-spleen) in Multi-organ Supportive Therapy (MOST) as a Modulator of Energy, for Immuno Correction Compensatory Anti-Inflammatory Response Syndromes, and Persistent Inflammation, Immuno suppression, Catabolism and Multi-organ Dysfunction

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Vasiliev I ◽  
Vasilieva M ◽  
Vasilieva I
Keyword(s):  
Inflammatory Response ◽  
Organ Dysfunction ◽  
Supportive Therapy ◽  
Persistent Inflammation ◽  
Anti Inflammatory

Systemic inflammation and cardiac surgery: an update

Perfusion ◽  
2001 ◽  
Vol 16 (5) ◽  
pp. 353-360 ◽  
Author(s):  
George Asimakopoulos
Keyword(s):  
Cardiac Surgery ◽  
Inflammatory Response ◽  
Organ Dysfunction ◽  
Systemic Inflammation ◽  
Cardiac Surgical Procedures ◽  
Action Mechanisms ◽  
Risk Patients ◽  
Potential Benefits ◽  
Anti Inflammatory ◽  
Inflammatory Action

Cardiac surgery with cardiopulmonary bypass (CPB) is associated with the development of a systemic inflammatory response that can often lead to dysfunction of major organs. The systemic inflammation can be assessed intra- and postoperatively by measuring concentrations of inflammatory mediators in plasma and tissues. These concentrations, however, do not always correlate with the degree of observed organ dysfunction. Various strategies have been used to reduce inflammatory phenomena in patients undergoing CPB. Cardiac surgery without CPB has been performed increasingly with satisfactory results over the past few years. Attenuation of systemic inflammation and improved outcome in high risk patients are potential benefits of this technique. The emergence and expanding performance of cardiac surgical procedures without the use of CPB has given us an excellent tool to investigate the relative importance of CPB as a cause of systemic inflammation. Aprotinin is a protease inhibitor which is used in cardiac surgical patients for its haemostatic effects. Aprotinin has anti-inflammatory properties, the nature of which have not been completely clarified. This article presents a summary of the published literature investigating inflammatory response and organ dysfunction in patients who have cardiac surgery without CPB. It also presents an overview of recent data on the anti-inflammatory action mechanisms of aprotinin.

scholarly journals Techniques to Study Inflammasome Activation and Inhibition by Small Molecules

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1704
Author(s):  
Diego Angosto-Bazarra ◽  
Cristina Molina-López ◽  
Alejandro Peñín-Franch ◽  
Laura Hurtado-Navarro ◽  
Pablo Pelegrín
Keyword(s):  
Inflammatory Response ◽  
Small Molecules ◽  
Mechanism Of Action ◽  
Inflammatory Diseases ◽  
Inflammasome Activation ◽  
Chronic Inflammatory Diseases ◽  
Anti Inflammatory ◽  
Inhibitory Molecules ◽  
Inflammasome Inhibitors

Inflammasomes are immune cytosolic oligomers involved in the initiation and progression of multiple pathologies and diseases. The tight regulation of these immune sensors is necessary to control an optimal inflammatory response and recover organism homeostasis. Prolonged activation of inflammasomes result in the development of chronic inflammatory diseases, and the use of small drug-like inhibitory molecules are emerging as promising anti-inflammatory therapies. Different aspects have to be taken in consideration when designing inflammasome inhibitors. This review summarizes the different techniques that can be used to study the mechanism of action of potential inflammasome inhibitory molecules.

scholarly journals Flaxseed orbitides, linusorbs, inhibit LPS-induced THP-1 macrophage inflammation

RSC Advances ◽  
2020 ◽  
Vol 10 (38) ◽  
pp. 22622-22630
Author(s):  
Xian-Guo Zou ◽  
Youn Young Shim ◽  
Jae Youl Cho ◽  
Deok Jeong ◽  
Jian Yang ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Cyclic Peptides ◽  
Underlying Mechanism ◽  
Anti Inflammatory

Linusorbs (flax orbitides) are a family of plant cyclic peptides. We investigate the anti-inflammatory activities of two different linusorbs ([1–9-NaC]-linusorb B2 and [1–9-NaC]-linusorb B3) and the underlying mechanism of this inflammatory response.

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