scholarly journals Expression Profile of Hepatic Metallothionein-I and ATP7B, and Brain Metallothionein-III and Acetyl cholinesterase Genes in Wistar Rat Model for Non-Wilsonian Brain Copper Toxicosis

2015 ◽  
Vol 2 (1) ◽  
Author(s):  
Pal A ◽  
Prasad R
Keyword(s):  
Expression Profile ◽  
Rat Model ◽  
Wistar Rat ◽  
Acetyl Cholinesterase ◽  
Copper Toxicosis ◽  
Hepatic Metallothionein

Therapeutic Efficacy of Trientine Nanoparticles in Wistar Rat Model of Copper Toxicosis

2016 ◽  
Vol 64 (2) ◽  
pp. S296-S297
Author(s):  
A. Pal ◽  
R. Prasad ◽  
B.R. Thapa ◽  
R.K. Vasishta
Keyword(s):  
Rat Model ◽  
Therapeutic Efficacy ◽  
Wistar Rat ◽  
Copper Toxicosis

4-Aminopyridine, A Blocker of Voltage-Dependent K+ Channels, Restores Blood Pressure and Improves Survival in the Wistar Rat Model of Anaphylactic Shock

2016 ◽  
Vol 44 (11) ◽  
pp. e1082-e1089 ◽  
Author(s):  
Abdelouahab Bellou ◽  
Suleiman Al-Hammadi ◽  
Elhadi H. Aburawi ◽  
Subramanian Dhanasekaran ◽  
Abderrahim Nemmar ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Rat Model ◽  
Anaphylactic Shock ◽  
Wistar Rat ◽  
K Channels ◽  
Voltage Dependent

scholarly journals A Subpressor Dose of Angiotensin II Elevates Blood Pressure in a Normotensive Rat Model by Oxidative Stress

2015 ◽  
pp. 153-159 ◽  
Author(s):  
M. M. GOVENDER ◽  
A. NADAR
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Angiotensin Ii ◽  
Mrna Expression ◽  
Rat Model ◽  
Wistar Rat ◽  
Control Group ◽  
Sod Activity ◽  
Male Wistar Rats ◽  
Experimental Group

Oxidative stress is an imbalance between free radicals and antioxidants, and is an important etiological factor in the development of hypertension. Recent experimental evidence suggests that subpressor doses of angiotensin II elevate oxidative stress and blood pressure. We aimed to investigate the oxidative stress related mechanism by which a subpressor dose of angiotensin II induces hypertension in a normotensive rat model. Normotensive male Wistar rats were infused with a subpressor dose of angiotensin II for 28 days. The control group was sham operated and infused with saline only. Plasma angiotensin II and H2O2 levels, whole-blood glutathione peroxidase, and AT-1a, Cu/Zn SOD, and p22phox mRNA expression in the aorta was assessed. Systolic and diastolic blood pressures were elevated in the experimental group. There was no change in angiotensin II levels, but a significant increase in AT-1a mRNA expression was found in the experimental group. mRNA expression of p22phox was increased significantly and Cu/Zn SOD decreased significantly in the experimental group. There was no significant change to the H2O2 and GPx levels. Angiotensin II manipulates the free radical-antioxidant balance in the vasculature by selectively increasing O2− production and decreasing SOD activity and causes an oxidative stress induced elevation in blood pressure in the Wistar rat.

scholarly journals The Protective Effect of Celecoxib on CA1 Hippocampal Neurons and Oxidative Stress in a Rat Model of Parkinson’s Disease

2019 ◽  
Author(s):  
Maryam Sarbishegi ◽  
Hamidreza Mahmoudzadeh-sagheb ◽  
Zahra Heidari ◽  
Farzaneh Baharvand
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Protective Effect ◽  
Passive Avoidance ◽  
Rat Model ◽  
Hippocampal Neurons ◽  
Wistar Rat ◽  
Tunel Staining ◽  
Model Animal ◽  
Avoidance Memory

Abstract- Several studies point to an important role of neuroinflammation in Parkinson's disease (PD). Cognitive and memory impairments have been known in the early stages of PD. In the present study, we examined the effects of celecoxib (CLX), a selective inhibitor of cyclooxygenase-2 (COX-2), on hippocampus cell loss, passive avoidance memory and antioxidant status in a rat model of PD. We used the subcutaneous injection of 2.5 mg/kg/48h rotenone (ROT) for 4 weeks for induction of PD in a male Wistar rat. Animals were randomized to 4 groups (n=12): Control, sham, PD and PD+CLX group that receive celecoxib (20 mg/kg/day) for 4 weeks. Passive avoidance memory evaluated. We also determined the protective effect of CLX on a number of CA1 neurons in Nissl and TUNEL staining. Total antioxidant capacity (TAC) and malondialdehyde (MDA) a marker of lipid peroxidation in hippocampus assessed. Our findings indicated administration of CLX increase the passive avoidance memory (P<0.05), and by a decrease in apoptosis caused an increase in viable pyramidal neurons in CA1 hippocampus (P<0.01). On the other hand, CLX markedly reduced MDA level and increased TAC in the hippocampus of the PD model animal (P<0.05). It seems CLX with anti-inflammatory and antiapoptotic effect could prevent neurons loss and memory impairment which induced in PD.

scholarly journals Absorbed dose evaluation at different organs after 131I oral contamination of two Wistar rat models

2019 ◽  
Vol 14 ◽  
pp. 07004
Author(s):  
Meriem Mezaguer-Lekouaghet ◽  
Eric Blanchardon ◽  
Abdelwahab Badreddine ◽  
Jean-Marc Bertho ◽  
Maamar Souidi ◽  
...  
Keyword(s):  
Rat Model ◽  
Bladder Wall ◽  
Thyroid Tissue ◽  
Absorbed Dose ◽  
Emission Spectra ◽  
Wistar Rat ◽  
Radiation Emission ◽  
Rat Models ◽  
Absorbed Doses ◽  
The Difference

Iodine-131 (131I) is one of the most frequently used radionuclides for diagnosis and therapy of thyroid diseases. It is administered orally in the treatment of cancer to eliminate the residual postoperative microscopic tumor foci, and the residual normal thyroid tissue for early detection of recurrence [1]. The comparative behavior of 131I concentration into two animalmodels with total and partial thyroid has been investigated in our previous work [2]. The accumulated activities have been measured in fourteen organs. In this study, the mean absorbed doses resulting from 131I accumulated in all organs have been evaluated using RODES software [3, 4]. With this software, mean absorbed doses were calculatedfor selected organs (thyroid, lungs, heart, liver, kidneys, stomach, spleen, large and small intestine, testes, urinary bladder wall) by combining the specific absorbed fractions (SAF) of energy with radiation emission spectra and biokinetic data determined from our previous experimental study [2]. Calculations were based on the 131I photon and electron emissions reported by [5] and SAFs previously calculated by Monte Carlo simulation in the voxel phantom of an adult male rate [3, 4]. The obtained results show high absorbed dosesdeliveredto stomach and lungs for both models compared to other organs. The dose received by the testes and salivary glands is found to be higher in the case of the rat model without thyroid. Conversely, the spleen and bladder wall received lower doses in this latter model compared to those received by the rat model with thyroid. One can also note that the difference in mean absorbed dose received by liver, lungs, heart, and walls of the stomach is not significant between the two rat models.

scholarly journals Seed and bark extracts of Acacia catechu protects liver from acetaminophen induced hepatotoxicity by modulating oxidative stress, antioxidant enzymes and liver function enzymes in Wistar rat model

2018 ◽  
Vol 108 ◽  
pp. 838-844 ◽  
Author(s):  
Thangavelu Lakshmi ◽  
Balusamy Sri Renukadevi ◽  
Sivanesan Senthilkumar ◽  
Perumalsamy Haribalan ◽  
R Parameshwari ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Enzymes ◽  
Liver Function ◽  
Rat Model ◽  
Wistar Rat ◽  
Acacia Catechu

scholarly journals Fresh raspberry phytochemical extract inhibits hepatic lesion in a Wistar rat model

2010 ◽  
Vol 7 (1) ◽  
pp. 84 ◽  
Author(s):  
Yan Liu ◽  
Ming Liu ◽  
Bin Li ◽  
Jin-Lu Zhao ◽  
Chun-Peng Zhang ◽  
...  
Keyword(s):  
Rat Model ◽  
Wistar Rat ◽  
Hepatic Lesion
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