Former Effective Immunotherapy without Adverse Events of Inoperable Epithelial Ovarian Cancers and a Prospect for the Immune Prophylaxis

Bukovsky A; Caudle MR

doi:10.15744/2454-3284.4.102

Former Effective Immunotherapy without Adverse Events of Inoperable Epithelial Ovarian Cancers and a Prospect for the Immune Prophylaxis

Journal of Gynecology Research ◽

10.15744/2454-3284.4.102 ◽

2018 ◽

Vol 4 (1) ◽

Author(s):

Bukovsky A ◽

Caudle MR

Keyword(s):

Adverse Events ◽

Ovarian Cancers

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Application of a risk scoring system to predict surgical adverse events in the management of epithelial ovarian cancers

Gynecologic Oncology ◽

10.1016/j.ygyno.2009.10.051 ◽

2009 ◽

Vol 115 (3) ◽

pp. 323-324 ◽

Cited By ~ 1

Author(s):

Andrew John Li

Keyword(s):

Adverse Events ◽

Scoring System ◽

Ovarian Cancers ◽

Risk Scoring ◽

Risk Scoring System ◽

Surgical Adverse Events

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Gastric Ulcers Produced by Cisplatin

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100099337 ◽

1981 ◽

Vol 39 ◽

pp. 582-583

Author(s):

S.K. Aggarwal ◽

J. San Antonio

Keyword(s):

Electron Microscopy ◽

Single Dose ◽

Side Effects ◽

Antitumor Agent ◽

Gastric Ulcers ◽

Enzyme Cytochemistry ◽

Intestinal Toxicity ◽

Ovarian Cancers ◽

Inner Surface

Cisplatin (cis-dichlorodiammineplatinum(II)) a potent antitumor agent is now available for the treatment of testicular and ovarian cancers. It is however, not free from its serious side effects including nephrotoxicity, gastro intestinal toxicity, myelosuppression, and ototoxicity. Here we now report that the drug produces peculiar bloating of the stomach in rats and induces acute ulceration.Wistar-derived rats weighing 200-250 g were administered cisplatin(9 mg/kg) ip as a single dose in 0.15 M NaCl. After 3 days the animals were sacrificed by decapitation. The stomachs were removed, the contents analyzed for pepsin and acidity. The inner surface was examined with a dissecting microscope after a moderate stretching for ulcers. Affected areas were fixed and processed for routine electron microscopy and enzyme cytochemistry.The drug treated animals kept on food and water consistently showed bloating and lesions (Fig. 1) with a frequency of 6-70 ulcers in the rumen section of the stomachs.

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