scholarly journals Human Neutrophils in Patients with Positive Serology for Chagas Disease

2016 ◽  
Vol 3 (1) ◽  
Author(s):  
Rodriguez FM ◽  
Orquera AD ◽  
Maturano MR ◽  
Infante NS ◽  
Carabajal-Miotti C ◽  
...  
Keyword(s):  
Chagas Disease ◽  
Human Neutrophils ◽  
Positive Serology

scholarly journals Triatomine Fauna and Recent Epidemiological Dynamics of Chagas Disease in an Endemic Area of Northeast Brazil

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Cláudia M. Melo ◽  
Ana Carla F. G. Cruz ◽  
Antônio Fernando V. A. Lima ◽  
Luan R. Silva ◽  
Rubens R. Madi ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Disease Control ◽  
Chagas Disease ◽  
Control Program ◽  
The State ◽  
Positive Serology ◽  
Serological Tests ◽  
Systemic Analysis ◽  
South Central ◽  
Disease Control Program

Updated information of the dispersion dynamics of Chagas disease (CD) and a systemic analysis of these data will aid the early identification of areas that are vulnerable to transmission and enable efficient intervention. This work synthesized spatiotemporal information regarding triatomine fauna and analyzed this information in combination with the results from serological tests to elucidate the epidemiological panorama of CD in the state of Sergipe, Brazil. This is a retrospective analytical study that utilized information from the database of the National Chagas Disease Control Program. Between 2010 and 2016, 838 triatomines of eight species, namely, Panstrongylus geniculatus, which was first recorded in the state of Sergipe, Panstrongylus lutzi, P. megistus, Triatoma brasiliensis, T. pseudomaculata, T. tibiamaculata, T. melanocephala, and Rhodnius neglectus, were collected. Optical microscopy revealed that 13.2% of triatomines examined were infected by Trypanosoma cruzi-like flagellates. The distribution of triatomines exhibits an expanding south-central to northern dispersion, with a preference for semiarid and agreste areas and occasional observations in humid coastal areas due to anthropogenic actions reflected in the environment. Of the human cases analyzed from 2012 to 2016, 8.3% (191/2316) presented positive serology for Trypanosoma cruzi, and this proportion showed a gradual increase in the southern center of the state and new notifications in coastal regions. There is a need for intensification and continuity of the measures adopted by the Chagas Disease Control Program in Sergipe, identifying new priority areas for intervention and preferential ecotopes of the vectors, considering the occurrence of positive triatomines intradomicilliary and a source of new triatomines in the peridomiciles.

PT257 Positive Serology tendency for chagas disease in public hospital of Buenos Aires suburbs, in an 18 year period

Global Heart ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e216
Author(s):  
Monica Graciela Galli ◽  
Eduardo E. Alvarez ◽  
Marcelo V. Boscaro ◽  
Juan Seresi ◽  
Gustavo Marquez ◽  
...  
Keyword(s):  
Chagas Disease ◽  
Public Hospital ◽  
Buenos Aires ◽  
Positive Serology

scholarly journals Serological survey for Chagas' disease in school children in the Rio de Janeiro State, Brazil

1976 ◽  
Vol 10 (2) ◽  
pp. 85-89
Author(s):  
Walter B. Petana ◽  
José Rodrigues Coura ◽  
Henry P. F. Willcox
Keyword(s):  
Chagas Disease ◽  
School Children ◽  
Rio De Janeiro ◽  
Serological Survey ◽  
Positive Serology ◽  
Blood Samples ◽  
Number Of Children ◽  
Triatomine Bugs ◽  
Fluorescence Test ◽  
Janeiro State

A serological survey for Chagas' disease was carried out in school children in the Rio de Janeiro State, a zone considered as non-endemic for the infection. A total of 168 schools in 20 municipalities have been visited and 13,254 blood samples were obtained. The blood eluates were screened by the indirect fluorescence test (IFT), and all positive samples were checked and confirmed in sera by the complement fixation test (CFT). AH serologically positive children were subject to a clinical scrutiny, and the houses where the children lived have been searched for triatomine bugs. Only in two municipalities, Magé and Araruama, there was a significant number of children found positive. The total number of reactive samples by IFT and CFT from 13,004 blood samples screened was 143 (1.00 per cent). No serious clinicai symptoms suggestive of Chagas' disease have been found in any of the positive children, and no triatomine bugs were discovered in the dwellings where the children lived. The overall small percentage of children with positive serology postulates that the infection is not a serious health problem in the area investigated. It is recommended, however, to carry out a more detailed study in Magé and Araruama to find the reason for the relatively high percentage of serologically positive children encountered in these two municipalities.

scholarly journals The indeterminate form of human chronic Chagas' disease: a clinical epidemological review

1989 ◽  
Vol 22 (3) ◽  
pp. 147-156 ◽  
Author(s):  
João Carlos Pinto Dias
Keyword(s):  
Natural History ◽  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Clinical Findings ◽  
X Rays ◽  
Classical Concept ◽  
Positive Serology ◽  
Indeterminate Form ◽  
History Of ◽  
Chronic Chagas Disease

Data on the epidemiology and the natural history of the indeterminate form of human chronic Chagas' disease (IFCCD) are discussed, revealing its great importance in endemic areas of Brazil. The work shows that IFCCD presents a gradual and very slow course, causing a benign picture in the studied patients. Evolution patterns, prognostic and anatomopathological features are also discussed. For practical purposes, the classical concept of IFCCD proved to be simple, operational and consistent, It is defined by the absence of symptoms and clinical findings in chronic infected patients with positive serology and/or parasitological examinations for Trypanosoma cruzi coupled with normal electrocardiographic and radiological exams (heart, oesophagus and colon X-Rays). If a patient is submitted to more rigorous and sophisticated tests, these can reveal some alterations, generally small ones and unable to interfere with the prognosis of the infection. It is suggested that research lines specially related to the evolution ary factors and immunological involvement during this phase be adopted.

scholarly journals Association between the elevation of biomarkers and incipient alterations in ventricular function in patients with Chagas disease without evidence of specific organ damage

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
D Chirino ◽  
C Dizeo ◽  
V Volverg ◽  
G Toledo ◽  
V Vecchio ◽  
...  
Keyword(s):  
Diastolic Function ◽  
Ventricular Function ◽  
Chagas Disease ◽  
Myocardial Damage ◽  
Tissue Doppler ◽  
S Wave ◽  
Positive Serology ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Abstract Background Chagas disease (ChD) has a long asymptomatic period, where there is no evidence of myocardial damage. However, incipient alterations in ventricular systo-diastolic function have been described using echocardiography with Tissue Doppler and Strain. On the other hand, the presence of elevated higth-sensitivity T troponin (HS-TnT) and N-terminal pro B-type natriuretic peptide (NT-pro BNP) has been documented in the early stages of the ChD. The association between the elevation of both markers and incipient alterations in ventricular function in patients with ChD without evidence of heart damage has been poorly studied. Purpose The aim of this study is to evaluate the prevalence of elevation of both biomarkers (HS-TnT and NT-proBNP) and their association with insipients alterations in systo-diastolic function in patients with ChD without evidence of structural heart affection. Materials and methods Outpatients with stage 0 of ChD (positive serology, with normal electrocardiogram, holter and chest teleradiography) were included prospectively. They were divided in three groups according to the dosage of HS-TnT and NT-proBNP. Group 1: patients with both markers within normal values; group 2: patients with elevation of one of the markers (HS-TnT>13 ng/L OR NT-proBNP>125 pg/ml) and group 3: patients with elevation of both markers (HS-TnT>13 ng/L AND NT-proBNP>125 pg/ml). All of them underwent Doppler echocardiography with tissue Doppler. Results Two hundred and sixty-one patients were included, with 47±9 years old of age, 44% woman, 86.6% (n=226) in group 1, 9.6% (n=25) in group 2 and 3.8% (n=10) in group 3. Table 1 shows the main results. Conclusions Elevation of both markers was found in almost 4% of patients. This elevation was associated with a higher E/e' ratio, E/A ratio, Letf Atrial Area and a lower S'-wave lateral. Funding Acknowledgement Type of funding source: None

scholarly journals Home invasion of triatomines increases the risk of Chagas disease transmission in the Brazilian Amazon

2020 ◽  
Author(s):  
BRUNA DANIELE LISBOA MOTA ◽  
Vera da Costa Valente ◽  
Francisco Lúzio de Paula Ramos ◽  
Sebastião Aldo da Silva Valente ◽  
Ana Yecê das Neves Pinto
Keyword(s):  
Chagas Disease ◽  
Disease Transmission ◽  
Parasitic Infection ◽  
Cross Sectional Study ◽  
Asymptomatic Infection ◽  
The State ◽  
Human Populations ◽  
Positive Serology ◽  
Cross Sectional ◽  
Vector Behaviour

Abstract Chagas disease is a parasitic infection with a large reemergent rates in some Amazon regions with usual features of outbreaks of the acute disease mainly by oral transmission. The main vectors of Trypanosoma cruzi are hematophagous insects, the triatomines. Some of them can establish themselves in human dwellings and their annexes but others are mostly wild. In the state of Pará, few records have been made about the occurrence of those wild vectors in fortuitous contact with inhabitants in riverside regions in the Amazon. These vector behaviours have been studied by our group since 2006, trying to explain their role in transmission of the silent disease or asymptomatic infection. The objective of this study is to describe the epidemiological profile of populations exposed to random triatomine home invasion in riverside areas with this registered occurrence. This is a cross-sectional study developed in Abaetetuba city, in the state of Pará, where we conducted a seroepidemiologic survey in inhabitants that registered triatomine home invasion. The results demonstrated that triatomine invasions occur especially in the in-home environment and in the rural zone. The genus Rhodnius was the most found in residences of the municipalities. Direct contact through the vector was reported by 15.55% of the total participants, and an unusual vector behaviour were observed during the day. Despite this small casuistic, 0.47% of the enrolled inhabitants had positive serology IgG anti- T. cruzi antibodies. We confirm one occurrence of asymptomatic infection in a child and, also, favourable links to the Chagas disease transmission chain. Faced with the scarcity of information on triatomine aggression in the Amazon, the authors recommended an entomological study of greater scope in those areas. The record of unusual vector behaviour and the serological surveillance of human populations under this risk may constitute a new tool for the early detection of silent infections and reinforce the knowledges about the behaviour of invading insects. At the same time, health education can assist in strategies for the prevention of Chagas' disease.

scholarly journals Chagas disease in Italy: breaking an epidemiological silence

2011 ◽  
Vol 16 (37) ◽  
Author(s):  
A Angheben ◽  
M Anselmi ◽  
F Gobbi ◽  
S Marocco ◽  
G Monteiro ◽  
...  
Keyword(s):  
Chagas Disease ◽  
Latin American ◽  
Wide Spectrum ◽  
Epidemiological Data ◽  
Tropical Diseases ◽  
Positive Serology ◽  
Population Movements ◽  
Health Measures ◽  
University Of Florence ◽  
Acute Chagas Disease

Chagas disease, a neglected tropical disease that due to population movements is no longer limited to Latin America, threatens a wide spectrum of people (travellers, migrants, blood or organ recipients, newborns, adoptees) also in non-endemic countries where it is generally underdiagnosed. In Italy, the available epidemiological data about Chagas disease have been very limited up to now, although the country is second in Europe only to Spain in the number of residents from Latin American. Among 867 at-risk subjects screened between 1998 and 2010, the Centre for Tropical Diseases in Negrar (Verona) and the Infectious and Tropical Diseases Unit, University of Florence found 4.2% patients with positive serology for Chagas disease (83.4% of them migrants, 13.8% adoptees). No cases of Chagas disease were identified in blood donors or HIV-positive patients of Latin American origin. Among 214 Latin American pregnant women, three were infected (resulting in abortion in one case). In 2005 a case of acute Chagas disease was recorded in an Italian traveller. Based on our observations, we believe that a wider assessment of the epidemiological situation is urgently required in our country and public health measures preventing transmission and improving access to diagnosis and treatment should be implemented.

Experience With Donors With Positive Serology for Chagas Disease in Liver Transplantation.

2014 ◽  
Vol 98 ◽  
pp. 733-734
Author(s):  
H. Noujaim ◽  
J. Branhez ◽  
L. Motta ◽  
R. dos Santos ◽  
C. Pedroso ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Chagas Disease ◽  
Positive Serology

scholarly journals Chagas' disease in the Brazilian Amazon: III. a cross-sectional sutdy

1995 ◽  
Vol 37 (5) ◽  
pp. 415-420 ◽  
Author(s):  
José Rodrigues Coura ◽  
Henry Percy Faraco Willcox ◽  
Margarita Arboleda Naranjo ◽  
Octavio Fernandes ◽  
Daurita Darci de Paiva
Keyword(s):  
Chagas Disease ◽  
Rural Areas ◽  
Brazilian Amazon ◽  
Positive Serology ◽  
Cross Sectional ◽  
Blood Samples ◽  
Rio Negro ◽  
The Right ◽  
The Town ◽  
Indirect Immunofluorescent

Two serological surveys for Chagas' infection were carried out, in 1991 and 1993, respectively, using a conglomerate family samples from the residents in the town of Barcelos (in the northern part of the State of Amazonas, on the right bank of the Rio Negro, 490 Km up-river from Manaus), using indirect immunofluorescent tests for anti-T. cruzi antibodies. In the first survey (1991), 628 blood samples from the residents of 142 dwellings were tested, showing positive in 12.7% for anti-T. cruzi antibodies and in 1993 an other 658 samples from residents of 171 dwellings showed positive in 13.7% of the tests, thus confirming the previous results. From 170 individuals with positive serology for T. cruzi antibodies, 112 (66%) were interviewed and submitted to electrocardiographic and clinical examinations; 82 (73.2%) of them gave consent for xenodiagnosis. From the 112 interviewed 52 (46.4%) recognized the triatomines as "piaçavas' lice", 48 (42.8%) knew the bugs from their work places being gatherers of piaçava fibers in rural areas and 19 (16.9%) said that have been bitten by bugs in their huts. Only 2 (2.4%) of 82 xenodiagnosis applied were positive for T. cruzi and 9 (8%) of the ECG had alterations compatible with Chagas' disease.

scholarly journals Working conditions of Chagas' disease patients in a large Brazilian city

1999 ◽  
Vol 15 (2) ◽  
pp. 381-386 ◽  
Author(s):  
Maria Elena Guariento ◽  
Maria Virgínia Fernandes Camilo ◽  
Ana Maria Arruda Camargo
Keyword(s):  
Chagas Disease ◽  
Working Conditions ◽  
Labor Union ◽  
University Hospital ◽  
Positive Serology ◽  
Working Age ◽  
Physical Examinations ◽  
The University ◽  
The City ◽  
Migratory Process

This study evaluated the working conditions of Chagas' disease patients in the city of Campinas, São Paulo, focusing on two-hundred-fifty patients with steady employment and treated at the University Hospital (HC-FCM/Unicamp): 98% were working-age and 77.6% were men. The origin of the patients reflected the migratory process occurring among this population. Most of the patients had limited professional skills, while 63.6% had not finished primary school and 21.6% were illiterate. However, 63.6% were regularly employed under duly processed work contracts. Their jobs were mainly in general services (21.6%) and heavy industry (21.2%). Some 55% of the patients reported a monthly income less than or equal to U$100.00, and 40.4% reported having been fired at least once during the last ten years, in 8.9% of the cases because of a diagnosis of Chagas' disease. Of the patients undergoing pre-hiring physical examinations (57.2%), 9.1% were refused, 92.3% of whom due to positive serology for T. cruzi. Finally, 78.4% reported not belonging to a labor union. The study demonstrated the precarious working conditions and discrimination experienced by workers with Chagas' disease.

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