Biological Effect Tetra-Branched Anti-TNF-Peptide and Coating Ratio-Dependent Penetration of the Peptide-Conjugated Cerium3/4+ Cation-Stabilized Gamma-Maghemite Nanoparticles into Rat Inner Ear after Transtympanic Injection Visualized By MRI

Zou J; Peng B; Ostrovsky S; Li B; Li C; Kettunen MI; Lellouche JP; Pyykkö I

doi:10.15744/2348-9812.5.204

Biological Effect Tetra-Branched Anti-TNF-Peptide and Coating Ratio-Dependent Penetration of the Peptide-Conjugated Cerium3/4+ Cation-Stabilized Gamma-Maghemite Nanoparticles into Rat Inner Ear after Transtympanic Injection Visualized By MRI

Journal of Materials Science and Nanotechnology ◽

10.15744/2348-9812.5.204 ◽

2017 ◽

Vol 5 (2) ◽

Author(s):

Zou J ◽

Peng B ◽

Ostrovsky S ◽

Li B ◽

Li C ◽

...

Keyword(s):

Inner Ear ◽

Biological Effect ◽

Maghemite Nanoparticles ◽

Ratio Dependent ◽

Coating Ratio

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Efficient penetration of ceric ammonium nitrate oxidant-stabilized gamma-maghemite nanoparticles through the oval and round windows into the rat inner ear as demonstrated by MRI

Journal of Biomedical Materials Research Part B Applied Biomaterials ◽

10.1002/jbm.b.33719 ◽

2016 ◽

Vol 105 (7) ◽

pp. 1883-1891 ◽

Cited By ~ 11

Author(s):

Jing Zou ◽

Stella Ostrovsky ◽

Liron L. Israel ◽

Hao Feng ◽

Mikko I. Kettunen ◽

...

Keyword(s):

Ammonium Nitrate ◽

Inner Ear ◽

Ceric Ammonium Nitrate ◽

Maghemite Nanoparticles

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Otoconia formation in the chick embryo

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100076494 ◽

1983 ◽

Vol 41 ◽

pp. 572-573

Author(s):

C.D. Fermin ◽

M. Igarashi

Keyword(s):

Chick Embryo ◽

Inner Ear ◽

Gallus Domesticus ◽

The Body ◽

Abnormal Behavior ◽

Intensive Study ◽

Basic Fuchsin ◽

Gestational Period ◽

Sensory Epithelia ◽

Transmission Electron

Otoconia are microscopic geometric structures that cover the sensory epithelia of the utricle and saccule (gravitational receptors) of mammals, and the lagena macula of birds. The importance of otoconia for maintanance of the body balance is evidenced by the abnormal behavior of species with genetic defects of otolith. Although a few reports have dealt with otoconia formation, some basic questions remain unanswered. The chick embryo is desirable for studying otoconial formation because its inner ear structures are easily accessible, and its gestational period is short (21 days of incubation).The results described here are part of an intensive study intended to examine the morphogenesis of the otoconia in the chick embryo (Gallus- domesticus) inner ear. We used chick embryos from the 4th day of incubation until hatching, and examined the specimens with light (LM) and transmission electron microscopy (TEM). The embryos were decapitated, and fixed by immersion with 3% cold glutaraldehyde. The ears and their parts were dissected out under the microscope; no decalcification was used. For LM, the ears were embedded in JB-4 plastic, cut serially at 5 micra and stained with 0.2% toluidine blue and 0.1% basic fuchsin in 25% alcohol.

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