scholarly journals Association of drug-induced gingival enlargement (calcium channel blockers) and local factors: Who is the culprit?

2017 ◽  
Vol 3 (1) ◽  
pp. 1-4
Author(s):  
Ajay Chouksey ◽  
Nitin Awasthi ◽  
Jayesh Rai ◽  
Abhishek Chaudhary
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Drug Induced ◽  
Local Factors ◽  
Gingival Enlargement

scholarly journals Cyclosporine A and amlodipine induced gingival overgrowth in a kidney transplant recipient: case presentation with literature review

2019 ◽  
Vol 12 (5) ◽  
pp. e229587 ◽  
Author(s):  
Tarun Nanda ◽  
Baljeet Singh ◽  
Parul Sharma ◽  
Karandeep Singh Arora
Keyword(s):  
Calcium Channel ◽  
Kidney Transplant ◽  
Cyclosporine A ◽  
Calcium Channel Blockers ◽  
Kidney Transplant Recipient ◽  
Kidney Transplant Patient ◽  
Channel Blockers ◽  
Drug Induced ◽  
Gingival Overgrowth ◽  
Gingival Enlargement

Drug-induced gingival overgrowth is a condition caused by side effects of treatment with one of three types of drugs: phenytoin (used in epilepsy treatment), cyclosporine A (used in transplantology after allogenic organ transplants) and calcium channel blockers (used in the treatment of hypertension). Gingival overgrowth leads to inflammation within the gums and periodontium and can amplify the existing periodontal disease leading to tooth loss. Patients who have undergone kidney transplant are given immunosuppressants to prevent transplant rejection and mostly it is accompanied with calcium channel blockers to treat hypertension associated with kidney transplant. This article reports a case of recent gingival enlargement associated with cyclosporine A and amlodipine given to a kidney transplant patient from the past 11 years.

EFFECTIVENESS OF NON-SURGICAL PERIODONTAL THERAPY ON AMLODIPINE INDUCED GINGIVAL ENLARGEMENT: A CASE REPORT

2019 ◽  
Vol 3 (11) ◽  
Author(s):  
Dagar Mona ◽  
Kataria Prerna
Keyword(s):  
Case Report ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Normal State ◽  
Periodontal Therapy ◽  
Channel Blockers ◽  
Scaling And Root Planing ◽  
Drug Induced ◽  
Gingival Overgrowth ◽  
Gingival Enlargement

Gingival enlargement, [sometimes abbreviated to GO (gingival overgrowth)] is an increase in the size of the gingiva. It is a common feature of gingival disease. Gingival enlargement is a well known side-effect of drugs like anticonvulsants, calcium channel blockers and immunosuppressant. A case of amlodipine induced gingival enlargement was reported and after drug substitution when the patient was treated non-surgically (scaling and root planing), the enlargement subsides to a normal state which suggested the effectiveness of non-surgical periodontal therapy in the treatment of drug induced gingival enlargement. Keywords: Anticonvulsants, Immunosuppressants, Calcium channel blockers, gingival enlargement

scholarly journals Gingival Enlargement in Antihypertensive Medication

2009 ◽  
Vol 48 (174) ◽  
pp. 149-52 ◽  
Author(s):  
Shaili Pradhan ◽  
P Mishra
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Antihypertensive Medication ◽  
Channel Blocker ◽  
Antihypertensive Agents ◽  
Channel Blockers ◽  
Drug Induced ◽  
Probing Depth ◽  
Increased Risk ◽  
Gingival Enlargement

Introduction: Drug-induced gingival enlargement is a well documented side effect with the use of phenytoin, cyclosporine and calcium channel blockers. The prevalence of gingival enlargement induced by calcium channel blockers is uncertain. Several studies show confl icting results ranging from 20% to 83%. This study was conducted to determine the prevalence of gingival enlargement in patients taking antihypertensive medication. Methods: All consecutive patients on antihypertensive agents attending the Dental OPD were studied. The prevalence of drug induced gingival enlargement was determined. The periodontal condition of all subjects were assessed including plaque index and probing depth. Results: Total 81.2% of subjects taking antihypertensive were seen to have signifi cant enlargement. Among them 71.1% were taking calcium channel blocker, 21.5% were taking ACE Inhibitors, and 7.4% were taking β- blockers. Conclusions:Patients taking antihypertensive agents are at increased risk for gingival enlargement and infl ammation is an important cofactor for the expression of this effect.Key Words: anti-hypertensive drugs, gingival enlargement

scholarly journals Gingival enlargement induced by dihydropyridine calcium channel blockers in a young child

2014 ◽  
Vol 2014 (sep08 1) ◽  
pp. bcr2014206761-bcr2014206761
Author(s):  
J. Miranda-Rius ◽  
L. Brunet-Llobet ◽  
E. Lahor-Soler ◽  
A. Ramirez-Ramiz
Keyword(s):  
Young Child ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Gingival Enlargement

scholarly journals Amlodipine induced generalized gingival overgrowth: A clinical case

2021 ◽  
Vol 6 (2) ◽  
pp. 125-127
Author(s):  
Sayani Shome ◽  
Amit De ◽  
Arup Ghosh ◽  
Ankita Saraf
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Geriatric Patient ◽  
Clinical Case ◽  
Gingival Tissue ◽  
Channel Blockers ◽  
Unique Case ◽  
Gingival Overgrowth ◽  
Management Protocol ◽  
Gingival Enlargement

Calcium channel blockers (CCB) like Amlodipine, Nifedipine etc are widely used as anti-hypertensive drugs which on chronic intake shows gingival enlargement. It is an iatrogenic response of gingival tissue to these drugs along with other category of medications like antiepileptics and immunosuppressants. A unique case of long standing gingival overgrowth due to prolonged usage of CCB such as Amlodipine in a geriatric patient are portrayed herewith clinical, histopathological attributes and management protocol.

scholarly journals A Rare Case Report of Amlodipine-Induced Gingival Enlargement and Review of Its Pathogenesis

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Sanjeev Joshi ◽  
Sucheta Bansal
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blocker ◽  
Periodontal Diseases ◽  
Clinical Feature ◽  
Channel Blockers ◽  
Gingival Hyperplasia ◽  
Unwanted Side Effect ◽  
Gingival Enlargement ◽  
Rare Case Report

Gingival enlargement is a common clinical feature of gingival and periodontal diseases. It is an unwanted side effect of certain systemic drugs given for nondental treatment. It is being reported with three main groups of drugs like calcium channel blockers (CCBs), immunosuppressants, and anticonvulsants. Among calcium channel blockers, nifedipine causes gingival hyperplasia in about 10% of patients, whereas the incidence of amlodipine-, a third generation calcium channel blocker, induced gingival hyperplasia is very limited. There are very few reports of amlodipine-induced gingival enlargement at a dose of 5 mg. We report a case of amlodipine-induced gingival enlargement in a 45-year-old hypertensive patient taking amlodipine at a dose of 5 mg.

scholarly journals Drug-induced atrial fibrillation associated with admission of cardiovascular medications

2020 ◽  
pp. 5-13
Author(s):  
O.D. Ostroumova ◽  
◽  
M.S. Chernyaeva ◽  
A.G. Komarova ◽  
S.V. Gorbatenkova ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cardiovascular Disease ◽  
Literature Review ◽  
Calcium Channel ◽  
Elderly People ◽  
Calcium Channel Blockers ◽  
Antiplatelet Agents ◽  
Channel Blockers ◽  
Drug Induced ◽  
Cardiovascular Medications

Admission of certain medications (drugs) can cause the development of atrial fibrillation (AF) in patients having non-evident cardiovascular disease (CVD). Also, it can accelerate the onset of AF in patients with pre-existing CVD. It is important to realize medications as potential cause of AF, especially in elderly people, since aging is associated with comorbidity and use of many medications simultaneously, that can lead to higher incidence of druginduced AF (DI AF). The article provides literature review on medications used to treat CVD, the admission of which can lead to the development of DI AF. Its onset can be associated with the use of cardiotonic, antiarrhythmic and antianginal medications, calcium channel blockers, diuretics, antiplatelet agents and some others with different evidence levels. The frequency, mechanisms of DI AF development and methods for its correction are described.

scholarly journals Laser Therapy In Drug Induced Gingival Hyperplasia- A Case Report

2021 ◽  
Vol 1 (2) ◽  
Keyword(s):  
Case Report ◽  
Calcium Channel ◽  
Laser Therapy ◽  
Calcium Channel Blockers ◽  
Treatment Modalities ◽  
Personal Satisfaction ◽  
Channel Blockers ◽  
Gingival Hyperplasia ◽  
Bacterial Burden ◽  
Drug Induced

Gingival excess is related with various components including innate infections, hormonal unsettling influences, helpless oral cleanliness condition, aggravation, neoplastic conditions, and unfavorable medication responses including anticonvulsants, calcium channel blockers, and immunosuppressants. This can have an inconvenient impact on the personal satisfaction and furthermore on high oral bacterial burden brought about by plaqueretentive regions. Different treatment modalities incorporate both careful (gingivectomy, periodontal fold, electrosurgery, and laser extraction) and nonsurgical methodologies. This case report reveals the treatment of drug induced gingival hyperplasia with laser

scholarly journals A rare case of accelerated gingival overgrowth with high dose amlodipine therapy

2021 ◽  
Vol 2 (1) ◽  
pp. 39-41
Author(s):  
Rakesh B M ◽  
Sahithi Sharma ◽  
Chandana K H
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Rare Case ◽  
Immunosuppressive Drugs ◽  
High Dose ◽  
Channel Blockers ◽  
Gingival Hyperplasia ◽  
Limited Evidence ◽  
Drug Induced ◽  
Gingival Overgrowth

Introduction: Gingival overgrowth represents an over-exuberant response to a variety of local and systemic conditions. Certain anticonvulsants, immunosuppressive drugs, and a number of calcium channel blockers have been shown to produce similar gingival overgrowth in susceptible patients. Case report: We report a case of accelerated drug-induced gingival overgrowth in a 60-year-old hypertensive patient taking amlodipine at a dose of 10 mg. Conclusions: Among the calcium channel blockers, nifedipine is most frequently associated with gingival overgrowth.  Whereas, there is limited evidence of amlodipine-induced gingival hyperplasia.

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