scholarly journals The Prevalence of Inducible and Constitutive Macrolide-lincosamide-streptogramin B-Resistant (iMLSB and cMLSB) Phenotypes among Clinical Isolates of Staphylococcus aureus at a Tertiary Care Hospital in South Mumbai

2021 ◽  
Vol 63 (1) ◽  
pp. 21-23
Author(s):  
Asmita S. Sakle ◽  
Srividhya Swaminathan
Keyword(s):  
Staphylococcus Aureus ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Clinical Isolates ◽  
Care Hospital

scholarly journals Susceptibility of Clinical Isolates of Staphylococcus aureus to Ceftaroline

2021 ◽  
Author(s):  
Harsha Sreedharan ◽  
KB Asha Pai
Keyword(s):  
Staphylococcus Aureus ◽  
Tertiary Care Hospital ◽  
Methicillin Resistance ◽  
Descriptive Analysis ◽  
Tertiary Care ◽  
The United States ◽  
Clinical Isolates ◽  
Diffusion Method ◽  
Clinical Samples ◽  
Care Hospital

Introduction: Methicillin-Resistant Staphylococcus aureus(MRSA) infection is a major global healthcare problem, the prevalence of which varies from 25-50% in India. It is known to cause Skin and Soft tissue Infections (SSI), endovascular infections, endocarditis, pneumonia, septic arthritis, osteomyelitis, and sepsis. Vancomycin is the drug of choice for treating severe MRSA infections. Ceftaroline, a fifth-generation cephalosporin has been approved by the United States Food and Drug Administration (US FDA) for treating acute bacterial SSI caused by susceptible micro-organisms including MRSA, Community acquired respiratory tract infection, MRSA bacteremia and endocarditis. Aim: To assess the susceptibility of clinical isolates of S. aureusto ceftaroline, in a Tertiary Care Hospital. Materials and Methods: This prospective study was conducted in the Department of Microbiology of a Tertiary Care Hospital over a period of two months from June 2019 to July 2019. S.aureus isolates from various clinical samples were screened for methicillin resistance by disc diffusion method using cefoxitin disc and ceftaroline susceptibility of these isolates was assessed by E-strip method. The isolates were classified as ceftaroline susceptible, Susceptibility Dose Dependent (SDD) and ceftaroline resistant respectively as per CLSI guidelines. A descriptive analysis of the data was done and the results were presented as frequencies and percentages. Results: All the S.aureus isolates were found to be susceptible to ceftaroline. Methicillin Sensitive Staphylococcus aureus(MSSA) isolates had lower Minimum Inhibitory Concentration (MIC) when compared to MRSA. The highest MIC among MRSA was 0.5 μg/mL. Conclusion: Ceftaroline can be considered as an effective alternative for treatment of infections caused by MRSA.

scholarly journals PROFILE OF STAPHYLOCOCCUS AUREUS ISOLATED FROM PATIENTS ADMITTED IN A TERTIARY CARE HOSPITAL WITH ESPECIAL REFERENCE TO METHICILLIN RESISTANCE

2020 ◽  
pp. 1-2
Author(s):  
Asmita Singh ◽  
Anita Pandey ◽  
Amit Singh ◽  
Priyanka Chaturvedi
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Agents ◽  
Tertiary Care Hospital ◽  
Methicillin Resistance ◽  
Tertiary Care ◽  
Hospital Setting ◽  
Clinical Isolates ◽  
Care Hospital ◽  
Wide Range ◽  
High Level

BACKGROUND: Staphylococcus aureus is a major human pathogen that causes wide range of clinical infections. Methicillin-resistant Staphylococcus aureus(MRSA) is endemic in India and is a dangerous pathogen causing hospital acquired infection leadings to signicant morbidity and mortality. OBJECTIVE:To study the prole of Staphylococcus aureusisolated from patients admitted in a tertiary care hospital. RESULT: Majority of clinical isolates of S.aurueswas obtained from patients of skin and soft tissue infection(54.66%) followed by those suffering from respiratory infection (13.33%), blood stream infection (13.33%) and UTI(8%). S.aureus was predominantly isolated from IPD samples, maximum cases were in the age group of 31-40 years and males outnumbered females. There was predominance of MRSA 112 (74.66%)which showed high level of resistance to penicillin (100%), ciprooxacin (82.14 %), co-trimoxazole (79.46%) and moxioxacin(85.71%). All the clinical isolates of S.aureuswere sensitive to linezolid andvancomycin (MIC <1ugm/ml). CONCLUSIONS: The clinical isolates of S.aureusshowed high level of resistance to various antimicrobial agents which is a signicant nosocomial threat. Surveillance and infection control practices should be carried out to prevent cross transmission of such resistant pathogen within the hospital setting

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