scholarly journals Centriolar satellites prevent uncontrolled degradation of centrosome proteins: a speculative review

Cell Stress ◽  
2018 ◽  
Vol 2 (2) ◽  
pp. 20-24 ◽  
Author(s):  
Nicolas Lecland ◽  
Andreas Merdes
Keyword(s):  
Centrosome Proteins

scholarly journals A Unique Set of Centrosome Proteins Requires Pericentrin for Spindle-Pole Localization and Spindle Orientation

2014 ◽  
Vol 24 (19) ◽  
pp. 2354
Author(s):  
Chun-Ting Chen ◽  
Heidi Hehnly ◽  
Qing Yu ◽  
Debby Farkas ◽  
Guoqiang Zheng ◽  
...  
Keyword(s):  
Spindle Pole ◽  
Spindle Orientation ◽  
Centrosome Proteins

Nuclear alignment in myotubes requires centrosome proteins recruited by nesprin-1

2016 ◽  
Vol 129 (22) ◽  
pp. 4227-4237 ◽  
Author(s):  
Aude Espigat-Georger ◽  
Vyacheslav Dyachuk ◽  
Cécile Chemin ◽  
Laurent Emorine ◽  
Andreas Merdes
Keyword(s):  
Nuclear Alignment ◽  
Centrosome Proteins

scholarly journals Inhibition of centrosome protein assembly leads to p53-dependent exit from the cell cycle

2006 ◽  
Vol 174 (5) ◽  
pp. 625-630 ◽  
Author(s):  
Vlastimil Srsen ◽  
Nicole Gnadt ◽  
Alexander Dammermann ◽  
Andreas Merdes
Keyword(s):  
Cell Cycle ◽  
Molecular Mechanisms ◽  
Human Fibroblasts ◽  
S Phase ◽  
Mitogen Activated Protein Kinase ◽  
Nuclear Antigen ◽  
Ki 67 ◽  
Mitogen Activated Protein ◽  
Centrosome Proteins ◽  
Centrosome Protein

Previous evidence has indicated that an intact centrosome is essential for cell cycle progress and that elimination of the centrosome or depletion of individual centrosome proteins prevents the entry into S phase. To investigate the molecular mechanisms of centrosome-dependent cell cycle progress, we performed RNA silencing experiments of two centrosome-associated proteins, pericentriolar material 1 (PCM-1) and pericentrin, in primary human fibroblasts. We found that cells depleted of PCM-1 or pericentrin show lower levels of markers for S phase and cell proliferation, including cyclin A, Ki-67, proliferating cell nuclear antigen, minichromosome maintenance deficient 3, and phosphorylated retinoblastoma protein. Also, the percentage of cells undergoing DNA replication was reduced by >50%. At the same time, levels of p53 and p21 increased in these cells, and cells were predisposed to undergo senescence. Conversely, depletion of centrosome proteins in cells lacking p53 did not cause any cell cycle arrest. Inhibition of p38 mitogen-activated protein kinase rescued cell cycle activity after centrosome protein depletion, indicating that p53 is activated by the p38 stress pathway.

scholarly journals USP9X inhibition enhances radiosensitisation of head and neck cancer cells in response to high-LET radiation by destabilizing centrosome proteins

2021 ◽  
Author(s):  
Maria Rita Fabbrizi ◽  
Catherine Nickson ◽  
Rachel Carter ◽  
Jonathan Hughes ◽  
Andrzej Kacperek ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
High Let Radiation ◽  
High Let ◽  
Centrosome Proteins

scholarly journals A Unique Set of Centrosome Proteins Requires Pericentrin for Spindle-Pole Localization and Spindle Orientation

2014 ◽  
Vol 24 (24) ◽  
pp. 2975
Author(s):  
Chun-Ting Chen ◽  
Heidi Hehnly ◽  
Qing Yu ◽  
Debby Farkas ◽  
Guoqiang Zheng ◽  
...  
Keyword(s):  
Spindle Pole ◽  
Spindle Orientation ◽  
Centrosome Proteins

Identification of new centrosome proteins by autoimmune patient sera

2007 ◽  
Vol 50 (2) ◽  
pp. 194-202 ◽  
Author(s):  
Liang Xia ◽  
Yan Li ◽  
Dong Yang ◽  
LiMin Wang ◽  
Fang He ◽  
...  
Keyword(s):  
Centrosome Proteins

scholarly journals Nuclei of Non-Muscle Cells Bind Centrosome Proteins upon Fusion with Differentiating Myoblasts

PLoS ONE ◽  
2009 ◽  
Vol 4 (12) ◽  
pp. e8303 ◽  
Author(s):  
Xavier Fant ◽  
Vlastimil Srsen ◽  
Aude Espigat-Georger ◽  
Andreas Merdes
Keyword(s):  
Muscle Cells ◽  
Centrosome Proteins

Immunolocalization of Centrosome Proteins in Prostate Cancer

2004 ◽  
Vol 10 (S02) ◽  
pp. 1550-1551
Author(s):  
Heide Schatten ◽  
Amitabha Chakrabarti ◽  
Angela Schmitt
Keyword(s):  
Prostate Cancer ◽  
Centrosome Proteins

Extended abstract of a paper presented at Microscopy and Microanalysis 2004 in Savannah, Georgia, USA, August 1–5, 2004.

scholarly journals A Unique Set of Centrosome Proteins Requires Pericentrin for Spindle-Pole Localization and Spindle Orientation

2014 ◽  
Vol 24 (19) ◽  
pp. 2327-2334 ◽  
Author(s):  
Chun-Ting Chen ◽  
Heidi Hehnly ◽  
Qing Yu ◽  
Debby Farkas ◽  
Guoqiang Zheng ◽  
...  
Keyword(s):  
Spindle Pole ◽  
Spindle Orientation ◽  
Centrosome Proteins
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