scholarly journals The analysis of efficacy of the use of inhibitor interleukin-1 in the complex therapy of secondary osteoarthritis taking into account the dynamics of clinical and functional indicators

2016 ◽  
Vol 71 (2) ◽  
pp. 141-147
Author(s):  
I. A. Starodubtseva ◽  
L. V. Vasilieva ◽  
A. V. Nikitin
Keyword(s):  
Laser Therapy ◽  
Interleukin 1 ◽  
Clinical Manifestations ◽  
Functional Condition ◽  
Underlying Disease ◽  
Complex Treatment ◽  
Secondary Osteoarthritis ◽  
Group Iii ◽  
Group I ◽  
Reduction Of Pain

Backgraund: Secondary osteoarthritis (OA) adversely affects an underlying disease and can enhance clinical manifestations of articular syndrome. Early detection of comorbid pathology and early treatment with the therapy of underlying condition is of primary importance to preserve adequate functional activity in patients.The Aims to analyze the efficacy of the use of inhibitor of interleukin -1 in the complex treatment of secondary OA in rheumatoid arthritis (RA).Materials and methods: 248 patients with secondary OA in RA were divided in 4 groups: patients of group I (n=62) took inhibitor of interleukin-1 (50mg x 2 times per day) in combination with laser therapy on the basis of methotrexate (10-20 mg per week), group II (n=60) received inhibitor of interleukin-1 in complex with methotrexate, in group III (n=62)-laser therapy with methotrexate and in group 4 – methotrexate. The analysis of treatment efficacy we estimated in 3 and 6 months according to the dynamics of pain on VAS, indexes HAQ and KOOS. Results: group 1 showed statistical significant reduction of pain on VAS on movement after 3 and 6 months on 28,53 mm (43,6%) and 31,3 мм (48%) accordingly, to values 36,87±1,56* и 33,11±1,11* (p0,05). It was noted the statistical significant advantages of HAQ dynamics in group I in comparison with groups II, III, IV (p=0,03). The most prominent statistical significant (p=0,02) significant advantages according to the dynamics of index KOOS it was noted in groups of patients who took diacerein (I and II) after 6 months complex treatment.Conclusions: the involvement of inhibitor of interleukin -1 in the complex treatment of secondary OA in patients with RA contributes to clinical improvement according to VAS (p=0,03), index KOOS, that shows functional condition of the knee and increase the quality of life by index HAQ (p=0,03) after 6 months therapy.

scholarly journals THE INFLUENCE OF COMPLEX THERAPY ON THE INFLAMMATORY MARKERS OF PATIENTS WITH SECONDARY OSTEOARTHRITIS

2015 ◽  
pp. 42-49 ◽  
Author(s):  
I. A. Starodubtseva
Keyword(s):  
Rheumatoid Arthritis ◽  
Laser Therapy ◽  
Inflammatory Markers ◽  
Interleukin 1 ◽  
Group Iv ◽  
Secondary Osteoarthritis ◽  
Das 28 ◽  
Group I ◽  
Model Surfaces ◽  
Complex Therapy

The aim of the study is to evaluate the efficacy of complex therapy of secondary osteoarthritis in patients with rheumatoid arthritis with the use of inhibitor of interleukin-1, including the dynamics of inflammatory markers.Materials and methods: 248 patients with secondary osteoarthritis in rheumatoid arthritis were involved in the trial. The participants were divided into 4 groups: patients of group I took inhibitor of interleukin-1 (diacerein) in combination with laser therapy and methotrexate; inhibitor of interleukin-1 in complex with methotrexate took patients from group II; group 3 — laser therapy + methotrexate and patients of group IV took only methotrexate. The efficacy of therapy we estimated in 6 months.Results: The constructed model surfaces indicated the decreased levels of IL-1, COMP and DAS 28 in group 1 till 6,68±0,37 pg/ml (p<0,001), 16,92±0,8 ng/ml х 10² (p<0,001) и 2,06±1,19 (p<0,05) accordingly in comparison with groups III and IV. Also the model surfaces revealed the interdependency of all these indicators. The control group (IV) reacted to the treatment by decreasing the indicators as well. However, the dynamics of the changes was significantly less. In patients of groups I and II the levels of ESR and CRP decreased to 13,95±0,52* (*p<0,001) and 10,97±0,43* (*p<0,001); 16,53±0,63* (*p<0,001) and 12,81±0,77* (*p<0,001) accordingly.Conclusions: In comparison analysis we noted statistical significant advantages (p<0,01) of the use of diacerein with methotrexate regarding the dynamic of IL-1 and COMP, ESR, CRP in patient’s serum, which is accompanied by the reduction of basic disease activity on DAS 28.

scholarly journals Assessment of the dynamics of dermatologic index indicators of symptom scale and dermatologic quality of life index under the influence of complex phototherapy in patients with a combination of rosacea subtypes

2020 ◽  
Vol 19 (6) ◽  
pp. 355-365
Author(s):  
Kirill A. Novikov ◽  
Olga B. Tamrazova ◽  
Yuliya I. Matushevskaya
Keyword(s):  
Quality Of Life ◽  
Laser Therapy ◽  
Clinical Manifestations ◽  
The Other ◽  
Symptom Scale ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
Index Of Quality

Background. Taking into account the data of recent studies on the treatment of rosacea, the development of new methods of treating this dermatosis using complex physiotherapeutic approaches and their synergism is of scientific and practical interest. In this work, we took into account the synergism of physiotherapeutic effects exerted by intense pulsed light and submilisecond neodymium 1064 nm laser radiation, as well as an increase in the destruction of pathologically altered vessels observed with the sequential use of both procedures. Aims: to assess the effect of complex phototherapy on changes in the indicators of the dermatological index of the symptom scale and the dermatological index of quality of life, reflecting the effect of the therapy on the clinical manifestations of the disease and the patient's subjective assessment of the skin condition. Material and methods. In the period 20172020 we conducted a randomized controlled study in which 130 patients with a combination of rosacea subtypes took part. All patients were divided into 4 groups. In each separate group, the following types of therapy were used: in group I laser therapy and 1% metronidazole cream; in group II phototherapy and 1% metronidazole cream; in group III complex photo-laser therapy and 1% metronidazole cream; in the comparison group (IV), patients received only 1% metronidazole cream. The treatment included 6 sessions with an interval of 2 weeks, with a total duration of 3 months. The effectiveness of therapy was assessed according to the results of the dermatological index of quality of life (DQL) and the dermatological index of the symptom scale (DYS) before and after treatment. Results. The developed complex method of combination of rosacea subtypes therapy demonstrated maximum efficiency, which was reflected in the maximum (by 55.21%) decrease in DYS in group III compared with the other three groups: in group I, the decrease in DYS was 30.54%, in II 21.51%, in IV 21.56%. The DQL in group III decreased by 67.4%, which was significantly higher than the indicators of the other three groups: in group I, DQL decreased by 31.3%, in group II by 27.4%, in IV by 20.7%. Conclusion. After the course of complex phototherapy in the group of patients with combination of rosacea subtypes, there was a decrease in the severity of clinical manifestations of the disease, as well as an increase in the quality of life of patients according to the data of the DYS and DQL, respectively.

scholarly journals Development of a lethal model of peritonitis for assessment of laparoscopic and laparotomic treatments in rats

2007 ◽  
Vol 22 (1) ◽  
pp. 39-42 ◽  
Author(s):  
Wilson Salgado Júnior ◽  
José Sebastião dos Santos ◽  
Fernando de Queiroz Cunha
Keyword(s):  
Interleukin 1 ◽  
Cecal Ligation ◽  
Blood Cultures ◽  
Necrosis Factor Alpha ◽  
Group Iii ◽  
Cell Counts ◽  
Group I ◽  
Leukocyte Counts ◽  
Factor Alpha ◽  
Group Ii

PURPOSE: Development of a lethal model of peritonitis to assess the results of treating that peritonitis using videolaparoscopy and laparotomy. METHODS: We developed a model of peritonitis in rats using cecal ligation (CLP) against a 2-mm diameter rigid mold and puncture. Two experiments were performed: determination of seven-day lethality; and analysis of white cell counts, blood cultures and cytokines (Interleukin-1 beta, Tumor Necrosis Factor-alpha and IL-6). The animals were divided into four groups: I - Sham surgery; II - CLP; III - CLP + Videolaparoscopy; and IV- CLP + Laparotomy . RESULTS: Seven-day lethality was 0% in group I, 80% in the group II (p<0.05), 60% in group III , and 20 % in group IV. There was a significant reduction in leukocyte counts and higher levels of serum IL-1 beta, TNF-alpha and IL-6 in the group II compared to controls. The percentages of positive blood cultures were higher after videolaparoscopic compared to laparotomic treatment. CONCLUSION: The experimental model provoked a lethal form of peritonitis and that videolaparoscopic treatment had more bacteraemia than laparotomy.

Using Ultrapure Water in Hemodialysis Delays Carpal Tunnel Syndrome

1991 ◽  
Vol 14 (11) ◽  
pp. 681-685 ◽  
Author(s):  
M. Baz ◽  
C. Durand ◽  
A. Ragon ◽  
K. Jaber ◽  
D. Andrieu ◽  
...  
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Carpal Tunnel ◽  
Interleukin 1 ◽  
Actuarial Survival ◽  
Group Iii ◽  
Kaplan Meier ◽  
Group I ◽  
Cellulose Acetate Membranes ◽  
Tunnel Syndrome ◽  
Stimulation Of

Since 1977, our patients have undergone chronic HD with ultra-pure dialysate (UPD), defined as having endotoxin levels below 0.008 ng/ml and less than 1 bacteria/ml of dialysate. We evaluated the incidence of carpal tunnel syndrome (CTS) in three groups of patients. Group I (GI), 84 patients, dialysed for 6.1 ± 3.2 years (mean ± SD) with UPD only; Group II (GII), 39 patients, first dialysed for 3.7 ± 2.3 years with non-UPD and afterwards for 8.4 ± 2.1 years with UPD; Group III (G III), 103 patients treated for 6 ± 5.9 years exclusively with non-UPD. All patients were dialysed with cuprophan or cellulose acetate membranes. Results, expressed by Kaplan-Meier actuarial survival curves as the percent of patients without CTS, show that CTS occurred significantly less in GI than in GIII. This may be due to less stimulation of monocytes resulting from the absence of bacteria, endotoxins and pyrogens in the dialysate which would reduce the stimulation of cytokines release, interleukin 1 and 6, and tumor necrosis factor, known to stimulate β2 microglobulin synthesis.

scholarly journals Features of manifestations, treatment and prevention of nsaids – induced gastroduodenopathy in patients of different profile departments

2019 ◽  
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Clinical Manifestations ◽  
Duodenal Ulcers ◽  
Group Iii ◽  
Treatment And Prevention ◽  
Group I ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Gastroduodenal Zone

Introduction. Nonsteroidal anti-inflammatory drugs are the most commonly used medicines in medical practice. As literary sources show, they often cause unwanted side-effects. The purpose of our work was to evaluate the frequency, clinical manifestations and morphological features of lesions of the gastroduodenal zone that arise in patients of rheumatologic, neurological profiles and angiosurgery department during the course of treatment with nonsteroidal anti-inflammatory drugs of different groups, to trace the dependence of the frequency of manifestations of the pathology of the stomach and duodenum from simultaneous receiving two nonsteroidal anti-inflammatory drugs and their combination with glucocorticosteroids and anticoagulants. Material and methods. 73 patients who had used NSAIDs for a long time and had endoscopically confirmed medicated gastroduodenopathy. Patients were divided into 3 groups depending on the profile of the department: Group I included - 24 patients of the department of vascular surgery; Group II - 23 patients of the neurological department; Group III - 26 patients with rheumatological profile. Results. Asymptomatic clinical picture of NSAID-gastropathy was found, which did not coincide with the available endoscopic changes in the gastroduodenal tube: in 63% of cases, erosive changes in the mucous membrane were present, and stomach and duodenal ulcers were revealed in 11%. It was also found that in the group of patients receiving proton pump inhibitors, the incidence of gastroduodenopathy was reliably lower (34.2%) than in patients who did not receive them (53.4%). During this study, it was found that the use of selective non-steroidal anti-inflammatory drugs can significantly reduce the probability of developing the pathology of the gastroduodenal zone, compared with non-selective. Conclusions. The course of treatment with nonsteroidal anti-inflammatory drugs should be as short as possible and should be carried out with minimal but effective doses. Parallel prophylactic administration of proton pump inhibitors is appropriate in patients at high risk of developing erosions and ulcers in the background of treatment with these drugs.

scholarly journals SPECIAL METHODS OF DIAGNOSIS OF THE FUNCTIONAL CONDITION OF THE LIVER IN PATIENTS WITH CIRRHOSIS

2020 ◽  
pp. 8-13
Author(s):  
A.V. Rusin ◽  
O.P. Balazh
Keyword(s):  
Liver Cirrhosis ◽  
Liver Damage ◽  
Biochemical Parameters ◽  
Functional Condition ◽  
Serum Biochemical Parameters ◽  
Group Iii ◽  
Group I ◽  
Significant Difference ◽  
Serum Biochemical ◽  
Multivariate Discriminant

Abstract. The aim. Using special methods to investigate the functional state of the liver in patients with cirrhosis. Materials and methods. The study involved 95 patients with LC who were hospitalized from 2018 to 2020 in the Department of Anesthesiology and Intensive Care, Surgical and Gastroenterological Departments of the Transcarpathian Regional Clinical Hospital. Andriy Novak (Uzhhorod). All patients underwent C13-metacetin breath test (C13-MDT) to determine the degree of liver damage. To determine the degree of fibrosis in the examined patients used the following specially developed tests: Forns test, FibroIndex test, FIB-4 test (Fibrosis 4 Score), APRI test (AST-to-Platelet Ratio Index), MDA test (multivariate discriminant analysis), test GUCI (Gothenburg University Cirrhosis Index), FPI test. Results. In all examined patients with LC on the results of C13-MDT revealed changes characteristic of liver cirrhosis. In group I of patients with LC, the percentage of functioning hepatocytes was 54.7 ± 5.3%. MFG was the lowest in group III patients with LC - 18.2 ± 1.8% and was statistically significantly different from patients in group I (p <0.05). A statistically significant difference between MFG parameters was also found between groups I and II of patients with LC - p <0.05. We found a strong correlation between the results of C13-MDT and histostructure disorders and the stage of liver damage (mainly F4) by METAVIR in the examined patients (r = 0.72; p <0.01). Based on the results of statistical analysis, it was found that the most effective test based on serum biochemical parameters is the FPI test. Conclusions. The most pronounced changes that characterize the reduced functional capacity of the liver, found in patients of group III - p <0,05. The most effective test based on serum biochemical parameters is the FPI test. Severe liver cirrhosis is characterized by higher plasma levels of endothelial mediators, fibrinolysis regulators and lower platelet counts, levels of physiological anticoagulants, prolonged invertebrate values.

scholarly journals NEUROPSYCHOLOGICAL STATUS OF PATIENTS WITH EPILEPSY AND CLINICAL MANIFESTATIONS OF CRANIOCEREBRAL DISPROPORATION ON THE BACKGROUND OF MODIFIED THERAPY

2018 ◽  
Vol 33 (3) ◽  
pp. 78-85
Author(s):  
V. I. Larkin ◽  
N. S. Stelmakh
Keyword(s):  
Standard Therapy ◽  
Clinical Manifestations ◽  
Epileptic Seizures ◽  
Primary Diagnosis ◽  
Long Term Memory ◽  
Group Iii ◽  
Average Value ◽  
Neuropsychological Status ◽  
Group I ◽  
Patients With Epilepsy

In the course of the study, 124 case records of patients with epileptic seizures (cryptogenic epilepsy) were analyzed. Diagnosis was established based on a typical clinical presentation, anamnesis, electroencephalogram (EEG) dynamics, and/or video EEG monitoring in the 10-hour format. Group I comprised 36 patients with normal liquor-cranial indexes ranging from 1.6 to 3.6 with an average value of 2.1±0.2; these patients received standard multicomponent therapy during the hospitalization and at the outpatient-polyclinic stage. Group II comprised 42 patients who had liquor-cranial indexes below the lower limit of normal ranging from 0.8 to 1.2 with an average value of 1.0±0.1; these patients also received therapy for primary diagnosis according to standard therapy scheme, which was identical to that in group I. Patients of group III (main group, n=46) had liquor-cranial indexes below physiological norm (from 0.8 to 1.2 with an average value of 0.9±0.1) and received modified therapy. Two-year follow up study showed that more severe cognitive deficit developed in patients with low cerebrovascular indexes receiving standard therapy compared to patients with low cerebrovascular indexes who received modified therapy. The absence of significant differences between patients of group I and III suggest that timely correction of increased intracranial pressure allowed to prevent significant aggravation of pathopsychological characteristics, loss of short-term and long-term memory, and overall cognitive function decline.

scholarly journals FEATURES OF CYTOKINE STATUS IN PATIENTS WITH CHRONIC EBV-INFECTIONS

2018 ◽  
Keyword(s):  
Viral Replication ◽  
Clinical Manifestations ◽  
Important Place ◽  
Group Iii ◽  
Ebv Infection ◽  
Group I ◽  
Tnf Α ◽  
Ifn Γ ◽  
High Degree

Infections caused by EBV are the most common and occupy an important place in the structure of herpes aetiology diseases. The purpose of this work was to study the characteristics of the cytokine status in patients with chronic EBV infection, depending on the level of viral replication. We examined 78 patients with chronic EBV infection, the main clinical manifestations of which were various immunopathological and immunodeficiency states: Group I – with low, Group II – with medium, Group III - with a high degree of viral replication. The Tiff method was used using the Vector-Best reagent kits (Novosibirsk, Russia) to study the cytokine profile in the serum of patients with EBV infection. The determination of alpha and gamma fractions of serum interferon was carried out using the ELISA method by means of the ProCon IF2 plus reagent kit manufactured by Protein Contour LLC (St. Petersburg, Russia). As a result of a study of the cytokine status in patients with chronic EBV infection, it was found that in all three groups there was a significant increase in both pro-inflammatory (IL-1β, IL-6, TNF-α) and antiinflammatory cytokines (IL-10, IL 4, TGFβ1). However, anti-inflammatory cytokinemia was more compensated in group I patients compared with patients in groups II and III. A decrease in IFN-α and IFN-γ was detected in all patients with chronic EBV infection while studying the interferon status. A correlation was found between the level of viral replication and a decrease in the level of IFN-α and IFN-γ. The identified features of the cytokine status in patients with chronic EBV infection can be used to optimize therapy and help develop a differentiated approach to the immunocorrection of these patients, depending on the level of viral replication.

Fluctuations in Plasma Levels of Thrombomodulin in Patients with DIC

1992 ◽  
Vol 68 (04) ◽  
pp. 404-406 ◽  
Author(s):  
Kagehiro Amano ◽  
Masaki Tateyama ◽  
Hiroshi Inaba ◽  
Katsuyuki Fukutake ◽  
Michio Fujimaki
Keyword(s):  
Underlying Disease ◽  
T Test ◽  
Initial Value ◽  
Membrane Injury ◽  
Group Iii ◽  
Group I ◽  
The Mean ◽  
Group Ii ◽  
Student’S T ◽  
Student’S T Test

SummaryPlasma thrombomodulin (TM) has attracted considerable attention as a marker of endothelial cell membrane injury. We examined fluctuations in plasma TM levels in patients receiving therapy for the disseminated intravascular coagulation syndrome (DIC) using an enzyme immunoassay. Sixty healthy controls and 18 patients with DIC were studied.The mean ± SD of the TM values initially measured immediately after the onset of DIC was 42.00 ± 20.85 ng/ml, which was markedly increased as compared with the control value of 15.36 ±4.85 ng/ml (p <0.001).Fluctuations in the TM levels over time were studied after dividing the patients according to the presence or absence of improvement in the underlying disease and improvement or lack thereof in the coagulation findings. Group I showed improvement in both categories, Group II showed improvement only in the latter, and Group III showed no improvement in either category.In Group I, the mean ± SD of initial measured TM levels was 37.02 ±10.12 ng/ml and the mean of final values decreased to 58.9% of the initial value. This decrease was significant by paired Student’s t-test (p <0.01). The initial value in Group II was 45.86 ± 18.86 ng/ml and the final values increased to 117.0% of the initial values, this difference was not significant. The initial value in Group III was 44.48 ±21.53 ng/ml and the final values increased to 143.4% of the former. This increase was significant by paired Student’s t-test (p <0.05). The difference in % fluctuations between Group I and Group III was significant by Wilcoxon’s test (p <0.01).These results suggest that the measurement of plasma TM can be useful in the management of DIC.

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