Associated Pathology in Case of Death from Circulatory Circulatory Diseases According to the Analysis of Multiple Causes

2021 ◽  
Vol 76 (4) ◽  
pp. 368-376
Author(s):  
Aleksandr V. Zubko ◽  
Tamara P. Sabgayda ◽  
Alla E. Ivanova ◽  
Galina N. Evdokushkina ◽  
Vyacheslav G. Zaporozhchenko ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Lymph Nodes ◽  
Circulatory System ◽  
Cerebrovascular Diseases ◽  
Frequency Effect ◽  
Risk Of Death ◽  
Lymph Vessels ◽  
Increased Risk ◽  
Icd 10

Background.Comorbidity of diseases deteriorates health and often increases the risk of death. Identification of comorbidities with diseases of the circulatory system (DCS) will help find additional measures to increase life expectancy. Aims to identify causes associated with death from DCS and to analyze their interrelation based on the multiple cause analysis. Materials and methods.Data on DCS deaths of the Death registration in the Moscow Unified Medical Information and Analytical System (RFS-EMIAS) in 2019 (46 000 deaths) and from April to May 2020 (11 000 deaths) excluding perinatal mortality were analyzed. The association analysis was carried out across groups of the ICD-10 DCS blocks by calculating the corresponding frequency. Effect of SARS-CoV-2 was analyzed in the infected deceased and those free from infection. Comparison was carried out by the Chi-square test. Results.The following Diseases of the circulatory system are associated with Diabetes mellitus: Hypertension, Coronary heart disease, Cerebrovascular diseases, and Diseases of arteries, arterioles and capillaries. A synergetic effect has been identified in comorbidity with the diseases characterized by high blood pressure and Chronic rheumatic heart diseases, other forms of heart disease(I30I52), Cerebrovascular diseases and Diseases of arteries, arterioles and capillaries; the latter and Coronary heart disease and Cerebrovascular diseases; other forms of heart disease and Mental disorders due to psychoactive substance use; Diseases of veins, lymphatic vessels and lymph nodes and Pulmonary circulation disorders. Effect of the increased risk of death in non-symmetric associations of causes has been detected for comorbidity of Diseases of veins, lymph vessels and lymph nodes and Chronic viral hepatitis; Coronary heart disease and other forms of heart disease; Hypertension and Coronary heart disease; in males comorbidity of Obesity and Hypertension, and Diseases of arteries, arterioles and capillaries and Hypertension. Associations between DCS and their complications have been identified in females: Diseases of veins, lymph vessels and lymph nodes and Phlegmon, and Cerebrovascular diseases and Decubital ulcers. Conclusion.SARS-CoV-2 increases mortality from Chronic coronary heart disease, ICD-10 I67.8 code for Other specified cerebrovascular diseases and Hypertension in females 1.5-fold. The infection rate in females died from DCS is significantly lower compared to the one in males.

scholarly journals Prevalence of diabetes and hypertension and their interaction effects on cardio-cerebrovascular diseases: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhehui Wang ◽  
Tubao Yang ◽  
Hanlin Fu
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Interaction Effects ◽  
Cross Sectional Study ◽  
Cerebrovascular Diseases ◽  
Sectional Study ◽  
Additive Interaction ◽  
Cross Sectional ◽  
Multiplicative Interaction ◽  
Increased Risk

Abstract Background Hypertension and diabetes mellitus are two of the major risk factors for cardio-cerebrovascular diseases (CVDs). Although prior studies have confirmed that the coexistence of the two can markedly increase the risk of CVDs, few studies investigated whether potential interaction effects of hypertension and diabetes can result in greater cardio-cerebrovascular damage. We aimed to investigate the prevalence of hypertension and diabetes and whether they both affect synergistically the risk of CVDs. Methods A cross-sectional study was conducted by using a multistage stratified random sampling among communities in Changsha City, Hunan Province. Study participants aged > = 18 years were asked to complete questionnaires and physical examinations. Multivariate logistic regression models were performed to evaluate the association of diabetes, hypertension, and their multiplicative interaction with CVDs with adjustment for potential confounders. We also evaluated additive interaction with the relative excess risk ratio (RERI), attribution percentage (AP), synergy index (SI). Results A total of 14,422 participants aged 18–98 years were collected (men = 5827, 40.7%). The prevalence was 22.7% for hypertension, 7.0% for diabetes, and 3.8% for diabetes with hypertension complication, respectively. Older age, women, higher educational level, unmarried status, obesity (central obesity) were associated with increased risk of hypertension and diabetes. We did not find significant multiplicative interaction of diabetes and hypertension on CVDs, but observed a synergistic additive interaction on coronary heart disease (SI, 1.43; 95% CI, 1.03–1.97; RERI, 1.94; 95% CI, 0.05–3.83; AP, 0.26; 95% CI, 0.06–0.46). Conclusions Diabetes and hypertension were found to be associated with a significantly increased risk of CVDs and a significant synergistic additive interaction of diabetes and hypertension on coronary heart disease was observed. Participants who were old, women, highly educated, unmarried, obese (central obese) had increased risk of diabetes and hypertension.

scholarly journals Association Between Dynamic Change of QT Interval and Long-Term Cardiovascular Outcomes: A Prospective Cohort Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Min Ye ◽  
Jing-Wei Zhang ◽  
Jia Liu ◽  
Ming Zhang ◽  
Feng-Juan Yao ◽  
...  
Keyword(s):  
Heart Rate ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
General Population ◽  
Dynamic Change ◽  
Cardiovascular Death ◽  
Coronary Heart Disease Death ◽  
Qtc Interval ◽  
Risk Of Death ◽  
Increased Risk

Background: The prolongation or shortening of heart rate-corrected QT (QTc) predisposes patients to fatal ventricular arrhythmias and sudden cardiac death (SCD), but the association of dynamic change of QTc interval with mortality in the general population remains unclear.Methods: A total of 11,798 middle-aged subjects from the prospective, population-based cohort were included in this analysis. The QTc interval corrected for heart rate was measured on two occasions around 3 years apart in the Atherosclerosis Risk in Communities (ARIC) study. The ΔQTc interval was calculated by evaluating a change in QTc interval from visit 1 to visit 2.Results: After a median follow-up of 19.5 years, the association between the dynamic change of QTc interval and endpoints of death was U-shaped. The multivariate-adjusted hazard ratios (HRs) comparing subjects above the 95th percentile of Framingham–corrected ΔQTc (ΔQTcF) (≥32 ms) with subjects in the middle quintile (0–8 ms) were 2.69 (95% CI, 1.68–4.30) for SCD, 2.51 (1.68–3.74) for coronary heart disease death, 2.10 (1.50–2.94) for cardiovascular death, and 1.30 (1.11–1.55) for death from any cause. The corresponding HRs comparing subjects with a ΔQTcF below the fifth percentile (<-23 ms) with those in the middle quintile were 1.82 (1.09–3.05) for SCD, 1.83 (1.19–2.81) for coronary heart disease death, 2.14 (1.51–2.96) for cardiovascular death, and 1.31 (1.11–1.56) for death from any cause. Less extreme deviations of ΔQTcF were also associated with an increased risk of death. Similar, albeit weaker associations also were observed with ΔQTc corrected with Bazett's formula.Conclusions: A dynamic change of QTc interval is associated with increased mortality risk in the general population, indicating that repeated measurements of the QTc interval may be available to provide additional prognostic information.

scholarly journals 282Social isolation and incident coronary heart disease in two large UK prospective studies

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Robert Smith ◽  
Isobel Barnes ◽  
Jane Green ◽  
Gillian Reeves ◽  
Valerie Beral ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Hospital Admission ◽  
Social Isolation ◽  
Hospital Admissions ◽  
Cox Regression ◽  
Coronary Event ◽  
Living Alone ◽  
Risk Of Death ◽  
Increased Risk

Abstract Background Social isolation is associated with CHD mortality but evidence of association with incident CHD is mixed. We prospectively examined this association in the Million Women Study (MWS) and UK Biobank (UKB). Methods 481,946 MWS and 456,612 UKB participants reported on social isolation (living alone, little contact with family/friends/groups). Excluding those reporting previous CHD or stroke, participants were followed for incident CHD using linkage to hospital admission and death records. Cox regression yielded relative risks (RR) by 3 levels of social isolation, adjusted for relevant confounders. Results During 7 years follow-up in the MWS and UKB, there were 42,402 first coronary heart disease events in total (of which 1,834 were fatal without an associated hospital admission). After adjustment, social isolation was not associated with hospital admission for first CHD events (combined RR for both studies: RR = 1.01, 95% CI: 0.98–1.04). However, the risk of fatal first CHD events without an associated hospital admission was substantially higher in the most isolated group than the least isolated group (1.86 [1.63–2.12]) This association with fatal first CHD events was driven by the association with living alone. Conclusions Social isolation was not associated with increased risk of first CHD hospital admissions but was associated with increased risk of death from CHD. Key messages Social isolation is likely not a risk factor for developing CHD, but people living alone may be at greater risk of dying from a coronary event than those not living alone.

Periodontitis, Edentulism, and Risk of Mortality: A Systematic Review with Meta-analyses

2020 ◽  
Vol 100 (1) ◽  
pp. 37-49 ◽  
Author(s):  
M. Romandini ◽  
G. Baima ◽  
G. Antonoglou ◽  
J. Bueno ◽  
E. Figuero ◽  
...  
Keyword(s):  
Systematic Review ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Diseases ◽  
Cerebrovascular Diseases ◽  
Increased Risk ◽  
Study Results ◽  
All Cause Mortality ◽  
Specific Mortality ◽  
Meta Analyses

Periodontitis has been independently associated with the chronic noncommunicable diseases that most frequently lead to death worldwide. The aim of the present systematic review was to study whether people with periodontitis/edentulism are at increased risk of all-cause and cause-specific mortality as compared with those without periodontitis/edentulism. Cohort studies were included that 1) evaluated periodontitis or edentulism as exposures in relation to all-cause or cause-specific mortality as an outcome and 2) reported effect estimates as hazard ratios, risk ratios, or odds ratios with 95% CIs or crude numbers. Two review authors independently searched for eligible studies, screened the titles and abstracts, did full-text analysis, extracted the data from the published reports, and performed the risk-of-bias assessment. In case of disagreement, a third review author was consulted. Study results were summarized through random effects meta-analyses. A total of 57 studies were included, involving 48 cohorts and 5.71 million participants. Periodontitis was associated with increased risk of all-cause mortality (risk ratio, 1.46 [95% CI, 1.15 to 1.85]) and mortality due to cardiovascular diseases (1.47 [1.14 to 1.90]), cancer (1.38 [1.24 to 1.53]), coronary heart disease (2.58 [2.20 to 3.03]), cerebrovascular diseases (3.11 [2.42 to 3.98]), but not pneumonia (0.98 [0.69 to 1.38]). Edentulism (all types) was associated with increased risk of all-cause mortality (1.66 [1.46 to 1.88]) and mortality due to cardiovascular diseases (2.03 [1.50 to 2.74]), cancer (1.55 [1.24 to 1.94]), pneumonia (1.72 [1.07 to 2.78]), coronary heart disease (2.98 [2.43 to 3.65]), and cerebrovascular diseases (3.18 [2.24 to 4.51]). Periodontitis and its ultimate sequela (edentulism) are associated with an increased risk of all-cause and cause-specific mortality (PROSPERO CRD42018100095).

scholarly journals Effect of High Temperatures on Daily Counts of Mortality from Diseases of Circulatory System in Astana, Kazakhstan

Medicina ◽  
2013 ◽  
Vol 48 (12) ◽  
pp. 94 ◽  
Author(s):  
Andrej Grjibovski ◽  
Nassikhat Nurgaliyeva ◽  
Aliya Kosbayeva ◽  
Altay Sharbakov ◽  
Telman Seysembekov ◽  
...  
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Circulatory System ◽  
Cerebrovascular Diseases ◽  
Ischemic Heart ◽  
Apparent Temperature ◽  
Inverse Association ◽  
Icd 10 ◽  
Hypertensive Diseases ◽  
The City

Background and Objective. Associations between hot temperatures and both overall and cardio- and cerebrovascular mortality have been observed in many European, North American, and Southeastern Asian cities. However, the effects varied among the settings with limited evidence from the countries with arid and semiarid climates. The aim of this study was to assess the effect of air temperature on deaths from the selected diseases of the circulatory system in the city of Astana, Kazakhstan. Material and Methods. The daily counts of deaths from hypertensive diseases (ICD-10 codes, I10–I15), cerebrovascular diseases (ICD-10 codes, I60–I69), and ischemic heart disease (ICD-10 codes, I20–I25) during the warm seasons (April-September) of 2000–2001 and 2006–2010 were obtained from the City Registry Office. The associations between the maximum apparent temperature (average of lags 0–3) and mortality were assessed by a first-order autoregressive Poisson regression with the adjustment for barometric pressure (average of lags 0–3), wind speed, and effects of month, year, holidays, and weekends. Results. Altogether, there were 282, 1177, and 2994 deaths from hypertensive diseases, cerebrovascular diseases, and ischemic heart disease, respectively. The maximum effective temperature varied between –2.2°C and 44.5°C. An increase in temperature by 1°C was associated with a 1.9% (95% CI, 0.3–3.5) increase in the daily number of deaths from cerebrovascular diseases and with a 3.1% (95% CI, 0.2–6.1) decrease in the number of deaths from hypertensive diseases among women. Conclusions. The results suggest a positive association between the maximum apparent temperature and the daily counts of deaths from cerebrovascular diseases and an inverse association between temperature and mortality from hypertensive diseases, but only among women.

scholarly journals Joint association between education and polygenic risk score for incident coronary heart disease events: a longitudinal population-based study of 26 203 men and women

2021 ◽  
pp. jech-2020-214358
Author(s):  
Pekka Martikainen ◽  
Kaarina Korhonen ◽  
Aline Jelenkovic ◽  
Hannu Lahtinen ◽  
Aki Havulinna ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Risk Score ◽  
Density Lipoprotein ◽  
Population Based ◽  
Polygenic Risk Score ◽  
Genome Wide ◽  
Increased Risk ◽  
Region Of Residence

BackgroundGenetic vulnerability to coronary heart disease (CHD) is well established, but little is known whether these effects are mediated or modified by equally well-established social determinants of CHD. We estimate the joint associations of the polygenetic risk score (PRS) for CHD and education on CHD events.MethodsThe data are from the 1992, 1997, 2002, 2007 and 2012 surveys of the population-based FINRISK Study including measures of social, behavioural and metabolic factors and genome-wide genotypes (N=26 203). Follow-up of fatal and non-fatal incident CHD events (N=2063) was based on nationwide registers.ResultsAllowing for age, sex, study year, region of residence, study batch and principal components, those in the highest quartile of PRS for CHD had strongly increased risk of CHD events compared with the lowest quartile (HR=2.26; 95% CI: 1.97 to 2.59); associations were also observed for low education (HR=1.58; 95% CI: 1.32 to 1.89). These effects were largely independent of each other. Adjustment for baseline smoking, alcohol use, body mass index, igh-density lipoprotein (HDL) and total cholesterol, blood pressure and diabetes attenuated the PRS associations by 10% and the education associations by 50%. We do not find strong evidence of interactions between PRS and education.ConclusionsPRS and education predict CHD events, and these associations are independent of each other. Both can improve CHD prediction beyond behavioural risks. The results imply that observational studies that do not have information on genetic risk factors for CHD do not provide confounded estimates for the association between education and CHD.

scholarly journals Is Childhood Socioeconomic Status Related to Coronary Heart Disease? Evidence From the Health and Retirement Study (1992-2012)

2017 ◽  
Vol 3 ◽  
pp. 233372141769667 ◽  
Author(s):  
Minjee Lee ◽  
M. Mahmud Khan ◽  
Brad Wright
Keyword(s):  
Socioeconomic Status ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Later Life ◽  
Study Data ◽  
Health And Retirement Study ◽  
Increased Risk ◽  
Childhood Socioeconomic Status ◽  
Nationally Representative ◽  
Retirement Study

Objective: We investigated the association between childhood socioeconomic status (SES) and coronary heart disease (CHD) in older Americans. Method: We used Health and Retirement Study data from 1992 to 2012 to examine a nationally representative sample of Americans aged ≥50 years ( N = 30,623). We modeled CHD as a function of childhood and adult SES using maternal and paternal educational level as a proxy for childhood SES. Results: Respondents reporting low childhood SES were significantly more likely to have CHD than respondents reporting high childhood SES. Respondents reporting both low childhood and adult SES were 2.34 times more likely to have CHD than respondents reporting both high childhood and adult SES. People with low childhood SES and high adult SES were 1.60 times more likely than people with high childhood SES and high adult SES to report CHD in the fully adjusted model. High childhood SES and low adult SES increased the likelihood of CHD by 13%, compared with high SES both as a child and adult. Conclusion: Childhood SES is significantly associated with increased risk of CHD in later life among older adult Americans.

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